5 terminated. 5 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Terminated 5 |
| Phase 2 | 2 | Terminated 2 |
Follow Acid-Base Imbalance: new trials by email Literature Review of Acid-Base Imbalance trials Research Report on Acid-Base Imbalance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bone in CKD Alkali Response (BICARb Pilot Trial) Potassium Citrate Extended Release Oral Tablet, Placebo, Potassium Citrate and Citric Acid Oral Solution - Chronic Kidney Diseases, Bone Loss | Phase 2 / Phase 3 | Terminated | Albert Einstein College of Medicine | 6 | 2024-08-15 | 2026-07-28 |
| Study Evaluating Subjects With Distal Renal Tubular Acidosis ADV7103, Placebo - Distal Renal Tubular Acidosis | Phase 3 | Terminated | Advicenne Pharma | 3 | 2021-09-20 | 2026-06-03 |
| Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease Sodium zirconium cyclosilicate, Placebo - Hyperkalaemia, Metabolic Acidosis | Phase 3 | Terminated | AstraZeneca | 39 | 2021-03-22 | 2023-10-06 |
| Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis TRC101, Placebo - Metabolic Acidosis, Chronic Kidney Disease | Phase 3 | Terminated | Tricida, Inc. | 1480 | 2018-11-20 | 2022-10-14 |
| Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Carbogen, Placebo - Febrile Seizure | Phase 2 / Phase 3 | Terminated | Charite University, Berlin, Germany | 96 | 2012-08-01 | 2018-01-26 |
Acidosis (3) · Renal Insufficiency, Chronic (3) · Acidosis, Renal Tubular (1) · Alkalosis, Respiratory (1) · Bone Diseases, Metabolic (1) · Fractures, Bone (1) · Hyperkalemia (1) · Seizures, Febrile (1)
Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Kidney Diseases (4) · Male Urogenital Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Urogenital Diseases (4) · Urologic Diseases (4) · Chronic Disease (3) · Disease Attributes (3) · Pathologic Processes (3) · Renal Insufficiency (3) · Acidosis (1)
Potassium Citrate (2) · Citric Acid (1) · Oxygen (1) · carbogen (1) · potassium bicarbonate (1) · sodium zirconium cyclosilicate (1) · veverimer (1)
Advicenne Pharma (1) · Albert Einstein College of Medicine (1) · AstraZeneca (1) · Charite University, Berlin, Germany (1) · Tricida, Inc. (1)
United States (4) · Canada (2) · Albania (1) · Argentina (1) · Armenia (1) · Australia (1) · Belarus (1) · Belgium (1) · Brazil (1) · Bulgaria (1) · Chile (1) · Colombia (1) · Czechia (1) · France (1) · Georgia (1)
Kimberly Reidy, MD (1) · Laurence Greenbaum, MD, Ph.D. (1)
PMID 34009141, PMID 38261535, PMID 38622759, PMID 39665575, PMID 41433250
2018 (1), 2023 (1), R01DK131811 (1)