7 completed, 1 active not recruiting, 1 withdrawn. 4 Phase 1, 3 Phase 2, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 3, Withdrawn 1 |
| Phase 2 | 3 | Completed 3 |
| Phase 3 | 3 | Completed 2, Active not recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome Zatolmilast/ BPN14770 - Fragile X Syndrome | Phase 3 | Active not recruiting | Tetra Discovery Partners | 314 | 2022-11-01 | 2025-10-03 |
| A Study of BPN14770 in Male Adults (Aged 18 to 45) With Fragile X Syndrome BPN14770/ zatolmilast, Placebo - Fragile X Syndrome | Phase 3 | Completed | Tetra Discovery Partners | 171 | 2022-11-01 | 2026-07-10 |
| A Randomized Study of BPN14770 in Male Adolescents (Aged 9 to < 18 Years) With Fragile X Syndrome zatolmilast, Placebo - Fragile X Syndrome | Phase 2 / Phase 3 | Completed | Tetra Discovery Partners | 163 | 2022-03-29 | 2026-08-31 |
| A Phase 1, Open-Label, PET Study of T2310 & BPN14770 BPN14770, T2310 - To Determine Brain Target Occupancy of BPN14770 | Phase 1 | Withdrawn | Tetra Discovery Partners | 2020-01-10 | 2022-01-10 | |
| Tetra PICASSO AD Trial: Study to Evaluate Effects of BPN14770 in Early Alzheimer's Subjects BPN14770, Placebo - Alzheimer's Disease | Phase 2 | Completed | Tetra Discovery Partners | 255 | 2019-04-30 | 2025-02-18 |
| A 2-Period Crossover Study of BPN14770 in Adults Males With Fragile X Syndrome BPN14770, Placebo - Fragile X Syndrome, FXS | Phase 2 | Completed | Tetra Discovery Partners | 30 | 2018-07-09 | 2024-12-19 |
| Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers BPN14770, BPN14770 placebo, Donepezil - Alzheimer Disease | Phase 1 | Completed | Tetra Discovery Partners | 38 | 2017-01-01 | 2018-10-16 |
| A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects BPN14770, Placebo - Alzheimer's Disease | Phase 1 | Completed | Tetra Discovery Partners | 77 | 2016-06-01 | 2017-01-18 |
| BPN14770 Single Ascending Dose Study in Healthy Male and Female Subjects BPN14770, Placebo - Alzheimer's Disease | Phase 1 | Completed | Tetra Discovery Partners | 32 | 2015-12-01 | 2017-01-18 |
Alzheimer Disease (4) · Fragile X Syndrome (4) · Dementia (2) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Developmental Disabilities (1) · Genetic Diseases, Inborn (1) · Learning Disabilities (1) · Mental Disorders (1) · Nervous System Diseases (1) · Neurocognitive Disorders (1)
BPN14770 (9) · Donepezil (1) · Scopolamine (1)
United States (9)
Elizabeth Berry-Kravis, MD (2) · Scott Reines, MD, PhD (2) · Cassandra Key, MD (1) · Paul D Mozley, MD (1) · Scott Reines, MD (1)