4 completed, 2 active not recruiting, 2 not yet recruiting, 2 terminated. 7 Not applicable, 3 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 4, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Phase 1 | 3 | Not yet recruiting 2, Withdrawn 1 |
| Phase 2 | 2 | Unknown 1, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SIMBA in Irritable Bowel Syndrome (IBS) Rifaximin (drug), fluid biopsy capsule - Irritable Bowel Syndrome (IBS), Microbiome | Phase 1 | Not yet recruiting | University of Calgary | 180 | 2026-11-01 | 2026-10-20 |
| Assessing the Safety of an IGY Supplement on the Gut Microbiome IgY supplement, Placebo - Healthy, Microbiome | Phase 1 / Phase 2 | Withdrawn | Nimble Science Ltd. | 2026-01-01 | 2026-09-30 | |
| Assessing Gut Microbiome Changes Before and After an Oral Nutritional Supplement Intake Using the SIMBA Capsule in Diabetic Participants Oral nutritional supplement - Type 2 Diabetes | Phase 1 | Not yet recruiting | Nimble Science Ltd. | 30 | 2025-09-01 | 2025-08-11 |
| Effects of Milk-based Drinks on Gut Microbiome, Sleep and Cardiometabolic Markers Original flavour kefir, Milk - Sleep, Cardiovascular Diseases | Not applicable | Recruiting | Sheffield Hallam University | 40 | 2025-08-01 | 2025-07-17 |
| To Evaluate the Feasibility of Collecting Duodenal Fluid With SIMBA Capsules SIMBA ingestion - Liver Cirrhosis | Not applicable | Completed | Vanessa Stadlbauer-Koellner, MD | 11 | 2025-06-10 | 2026-06-22 |
| The Digestion of Protein Powders in Healthy Participants Using SIMBA and LIMBA Capsule Milk Protein Concentrate, Micellar Casein Isolate - Amino Acid Change, Food Science | Not applicable | Completed | Nimble Science Ltd. | 24 | 2024-11-10 | 2026-10-20 |
| The Safety And Efficacy Of A Probiotic Intervention On Lactulose Hydrogen Breath Test-Positive Patients And Related Gastrointestinal Symptoms Probiotic - Small Intestinal Bacterial Overgrowth, SIBO | Not applicable | Active not recruiting | Nimble Science Ltd. | 105 | 2024-07-10 | 2026-09-30 |
| Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Disease Fluid biopsy capsule, Levodopa-Carbidopa Immediate Release - Parkinson Disease | Terminated | Nimble Science Ltd. | 51 | 2024-02-19 | 2026-10-20 | |
| Evaluation of the Microbiome in Multiple Sclerosis SIMBA Capsule - Multiple Sclerosis | Not applicable | Terminated | Nimble Science Ltd. | 40 | 2023-06-26 | 2025-05-15 |
| A Clinical Trial of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder FMT Capsule + SIMBA Capsule - Obsessive-Compulsive Disorder | Phase 2 | Unknown | Valerie Taylor | 20 | 2023-06-01 | 2023-11-30 |
| Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis fluid biopsy capsule - Irritable Bowel Syndrome, Crohn Disease | Active not recruiting | Nimble Science Ltd. | 300 | 2023-01-09 | 2026-09-30 | |
| Validation of the Small Intestine Microbiome Aspiration (SIMBA) Capsule Ingestible capsule, Sedated EGD, Lactulose Breath Test - Proof of Concept, Irritable Bowel Syndrome | Not applicable | Completed | University of Calgary | 30 | 2021-10-27 | 2022-09-02 |
| Dietary Intervention Detection in the Small Intestine Ingestible Capsule, Probiotic - Proof of Concept | Not applicable | Completed | Nimble Science Ltd. | 20 | 2020-12-22 | 2021-09-08 |
Irritable Bowel Syndrome (4) · Diabetes Mellitus, Type 2 (2) · Cardiovascular Diseases (1) · Celiac Disease (1) · Colitis, Ulcerative (1) · Congenital Microtia (1) · Crohn Disease (1) · Dilatation, Pathologic (1) · Gastrointestinal Diseases (1) · Liver Cirrhosis (1) · Multiple Sclerosis (1) · Obsessive-Compulsive Disorder (1) · Parkinson Disease (1)
Probiotics (2) · Dietary Supplements (1) · Fecal Microbiota Transplantation (1) · Milk (1) · Pharmaceutical Preparations (1) · Rifaximin (1) · carbidopa, levodopa drug combination (1)
Canada (11) · Austria (1) · United Kingdom (1)
Carlos Camara-Lemarroy (1) · Chris Andrews, MD (1) · Chris Andrews, MD MSc (1) · Christopher N Andrews (1) · Christopher N Andrews, MD MSc (1) · Davide Martino, MD PHD (1) · Matthew Woo, MD (1) · Tony Lynn, PhD (1) · Valere Taylor, MD,PhD,FRCPC (1)