42 completed, 10 unknown, 8 recruiting, 5 not yet recruiting. 21 Phase 4, 18 Phase 3, 8 Not applicable, 8 Phase 1, 5 Phase 2.
Follow Vonoprazan: new trials by email Literature Review of Vonoprazan trials Research Report on Vonoprazan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vonoprazan-Amoxicillin Dual Therapy for Helicobacter Pylori Infection in United States Adolescents Vonoprazan, Amoxicillin - Helicobacter Pylori Infection | Phase 2 | Not yet recruiting | Boston Children's Hospital | 55 | 2026-11-01 | 2026-10-06 |
| Vonoprazan High-Dose Dual VS Levofloxacin Concomitant Vonoprazan, Levofloxacin 500mg - Helicobacter Pylori Infection, Peptic Ulcer Disease | Phase 4 | Not yet recruiting | Damascus Hospital | 150 | 2026-11-01 | 2026-06-03 |
| A Study to Evaluate the Efficacy and Safety of Vonoprazan 10 mg Compared to Placebo for Relief of Episodic Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease Through 24 Weeks Vonoprazan, Placebo - Symptomatic Non-erosive Gastroesophageal Reflux Disease | Phase 3 | Recruiting | Phathom Pharmaceuticals, Inc. | 500 | 2026-09-25 | 2026-10-07 |
| Comparison of Rabeprazole and Vonoprazan in the Prevention of Post-endoscopic Variceal Ligation Ulcer in Patients With Cirrhosis Vonoprazan, Rabeprazol - Endoscopic Variceal Band Ligation | Phase 3 | Not yet recruiting | King George's Medical University | 300 | 2026-05-01 | 2026-05-27 |
| Vonoprazan Alone vs With Itopride for Functional Dyspepsia: The VIVA Trial Vonoprazan plus Itopride combination, Vonoprazan - Functioanl Dyspepsia | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 192 | 2026-01-10 | 2026-07-28 |
| A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 414 | 2025-12-20 | 2026-03-06 |
| A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks Vonoprazan, Placebo - Eosinophilic Esophagitis | Phase 2 | Active not recruiting | Phathom Pharmaceuticals, Inc. | 95 | 2025-10-30 | 2026-10-13 |
| A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring Vonoprazan - Erosive Esophagitis, Heartburn | Recruiting | Phathom Pharmaceuticals, Inc. | 728 | 2025-05-15 | 2026-09-18 | |
| Zuojin Wan Combined with Vonoprazan-Amoxicillin Dual Therapy in H.Pylori Eradication Vonoprazan, Amoxicillin, Zuojin Wan - Helicobacter Pylori Infection | Early Phase 1 | Unknown | Nanjing First Hospital, Nanjing Medical University | 136 | 2025-05-01 | 2025-03-28 |
| Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 300 | 2025-04-30 | 2026-04-27 |
| Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial Vonoprazan, Tetracycline 500mg tid, Minocycline - Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer | Phase 4 | Recruiting | Yongquan Shi | 400 | 2025-04-01 | 2025-08-14 |
| Head-to-head Study of Tegoprazan 50 mg BID Plus Amoxicillin 1 g TID vs. Vonoprazan 20 mg BID Plus Amoxicillin 1 g TID for H. Pylori Eradication Tegoprazan, Amoxicillin, Vonoprazan - Helicobacter Pylori Infection | Phase 2 / Phase 3 | Recruiting | First People's Hospital of Hangzhou | 240 | 2025-02-17 | 2025-11-21 |
| Comparison of the Efficacies of Two Novel Dose Dual Therapies in the First-line Helicobacter Pylori Eradication Vonoprazan, Esomeprazole 40mg, Amoxicillin - HELICOBACTER PYLORI INFECTIONS | Phase 3 | Unknown | Chang Gung Memorial Hospital | 300 | 2025-02-01 | 2025-02-12 |
| Efficacy of a 14-Day Bismuth-Containing Quadruple Therapy Guided by Drug Susceptibility Testing in Patients with Extremely Refractory Helicobacter Pylori Infection: an Exploratory Study Bismuth, Vonoprazan, Amoxicillin - HELICOBACTER PYLORI INFECTIONS | Not yet recruiting | Xiuli Zuo | 30 | 2025-01-01 | 2024-12-19 | |
| Comparison of Esomeprazole Versus Vonoprazan in Gastroesophageal Reflux Disease Esomeprazole, Vonoprazan - Gastro Esophageal Reflux | Not applicable | Completed | Muhammad Aamir Latif | 824 | 2025-01-01 | 2026-05-04 |
| Triple Versus Quadruple Therapy for the Eradication of Helicobacter Pylori Vonoprazan-Amoxicillin-Tetracycline-Bismuth quadruple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 7 days - Helicobacter Pylori Infection | Not applicable | Unknown | Shandong University | 375 | 2024-11-27 | 2024-12-03 |
| Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication Berberine, Vonoprazan, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 558 | 2024-09-20 | 2025-07-03 |
| High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection Vonoprazan, Amoxicillin, Bismuth Potassium Citrate - Helicobacter Pylori Infection | Phase 4 | Unknown | Shanghai Jiao Tong University School of Medicine | 200 | 2024-08-21 | 2024-12-30 |
| Optimization of Minocycline for Helicobacter Pylori Rescue Treatment Vonoprazan, Bismuth Potassium Citrate, Tetracycline,Metronidazole - Helicobacter Pylori Infection | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 480 | 2024-08-21 | 2026-03-25 |
| Efficacy and Safety of Vonorasan Versus Esomeprazole in the Treatment of Ulcers After Endoscopic Submucosal Dissection Vonoprazan, Esomeprazole - Ulcers, Gastric | Phase 4 | Not yet recruiting | Shicai Ye | 196 | 2024-08-01 | 2024-07-29 |
Showing 20 of 68. Sign in to see all of them.
Gastroesophageal Reflux (10) · Duodenal Ulcer (5) · Heartburn (4) · Esophagitis, Peptic (3) · Gastritis (3) · Stomach Ulcer (3) · Peptic Ulcer (2) · cyclopia sequence (2) · Digestive System Diseases (1) · Dyspepsia (1) · Eosinophilic Esophagitis (1) · Esophagitis (1) · Gastrointestinal Diseases (1) · Gastrointestinal Hemorrhage (1) · Hypertension, Portal (1)
Takeda (15) · Phathom Pharmaceuticals, Inc. (14) · Nanjing First Hospital, Nanjing Medical University (5) · Shanghai Jiao Tong University School of Medicine (4) · Alexandria University (3) · Asian Institute of Gastroenterology, India (3) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Xijing Hospital of Digestive Diseases (2) · Yongquan Shi (2) · Ain Shams University (1) · Boston Children's Hospital (1) · Chang Gung Memorial Hospital (1) · Changi General Hospital (1) · Chinese University of Hong Kong (1) · Damascus Hospital (1)
China (29) · United States (14) · Japan (9) · Taiwan (5) · Egypt (4) · India (4) · South Korea (4) · Bulgaria (3) · Czechia (3) · Philippines (3) · Poland (3) · United Kingdom (3) · Hungary (2) · Malaysia (2) · Belgium (1)
Zhenyu Zhang (3) · Mohan Dr Ramchandani, MD DM (2) · Sameh A Lashen, MD (2) · Wanli Liu, Doctorate (2) · Bin Cheng, Doctor (1) · Daphne Shih Wen Ang, MD (1) · Dr Sumit Rungta, DM- Medical Gastroenterology (1) · Dr.Mohan Kumar Ramchandani, MD, DM (1) · Faraz Ahmad (1)
PMID 29739175, PMID 32088712, PMID 39085080, PMID 11396765, PMID 20074379, PMID 21155009, PMID 21947706, PMID 25583938, PMID 25951490, PMID 26559637, PMID 26937932, PMID 27105595, PMID 28119763, PMID 28357069, PMID 28366993, PMID 28567114, PMID 28614248, PMID 28894571, PMID 30504527, PMID 30944817, PMID 31243237, PMID 31409606, PMID 31875670, PMID 33839101, PMID 34247436, PMID 35120736, PMID 35294415, PMID 35679950, PMID 35719338, PMID 36191284, PMID 36228734, PMID 36264125, PMID 36458325, PMID 37750406, PMID 37975046, PMID 38582271, PMID 38654422, PMID 38750866, PMID 39087868, PMID 39209187, PMID 39965795, PMID 40196374, PMID 40481714, PMID 40543051, PMID 40984972, PMID 41081570, PMID 41131746, PMID 41732217, PMID 41982134, PMID 42141850
2019 (2), 2015 (1)