28 completed, 5 unknown, 2 active not recruiting, 2 terminated. 39 Phase 3, 16 Phase 2.
Follow Vitamin B 12: new trials by email Literature Review of Vitamin B 12 trials Research Report on Vitamin B 12
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week Cyanocobalamin 1000 Mcg Oral Tablet, Cyanocobalamin 1000 Mcg Sublingual Tablet, Proton Pump Inhibitor therapy only - Hypovitaminosis b 12 | Phase 3 | Not yet recruiting | Tanta University | 23 | 2026-12-30 | 2025-05-13 |
| Combination Gerotherapeutic Interventions for Healthspan Improvement Rapamycin, Naltrexone, Metformin - Healthspan Improvement, Aging | Phase 3 | Completed | AgelessRx | 26 | 2025-07-23 | 2026-10-30 |
| Efficacy and Safety of Etoricoxib/Cyanocobalamin Versus Etoricoxib for Acute Low Back Pain Etoricoxib + Cyanocobalamin fixed dose, Etoricoxib fixed dose - Acute Low-back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 190 | 2024-04-26 | 2024-11-27 |
| Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome Prednisolone 20 mg/ 5 mg, Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12), Placebo for Vitamin B compound - Post-COVID-19 Syndrome | Phase 3 | Completed | Wuerzburg University Hospital | 321 | 2022-11-11 | 2025-04-01 |
| Pregabalin Versus Gabapentin Opioid Sparing Effect in Discectomy Pregabalin 150mg gabapentin 400mg - Opioid Use | Phase 3 | Unknown | Research Institute of Ophthalmology, Egypt | 72 | 2022-09-15 | 2022-10-27 |
| Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) Cobalamin, Dexamethasone, Docetaxel - Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma | Phase 2 / Phase 3 | Active not recruiting | SWOG Cancer Research Network | 82 | 2022-03-15 | 2026-05-18 |
| Study of Pemetrexed+Platinum Chemotherapy With or Without Cosibelimab in First Line Metastatic Non-squamous NSCLC Cosibelimab, Cisplatin, Carboplatin - Metastatic Non-squamous Non Small Cell Lung Cancer | Phase 3 | Terminated | Checkpoint Therapeutics, Inc. | 25 | 2021-12-08 | 2025-04-02 |
| Early Infant Micronutrition and Development Cyanocobalamin - Vitamin B 12 Deficiency | Phase 2 / Phase 3 | Recruiting | Sykehuset Innlandet HF | 600 | 2021-12-08 | 2023-04-18 |
| Vitamin B12 vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury Vitamin B3, Vitamin B12 - Traumatic Brain Injury | Phase 3 | Completed | KRL Hospital, Islamabad | 300 | 2021-06-01 | 2023-07-24 |
| The Benefit of Add On DLBS1033 for Ischemic Stroke Patient DLBS1033, Aspirin, Statin - Ischemic Stroke | Phase 2 / Phase 3 | Unknown | Duta Wacana Christian University | 180 | 2020-04-01 | 2020-06-11 |
| Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics Pyridoxine, Cobalamin, Placebo Oral Tablet - Schizophrenia, Drug Induced Movement Disorder, Unspecified | Phase 2 / Phase 3 | Unknown | Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara | 45 | 2019-09-03 | 2019-12-18 |
| Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass Hydroxycobalamin - Vasoplegic Syndrome | Phase 2 / Phase 3 | Completed | Ain Shams University | 60 | 2019-08-28 | 2024-06-12 |
| Evaluation of the Clinical Efficacy and Safety of Dapoxetine, Combined Dapoxetine With Folic Acid and Combined Dapoxetine With Vitamin B12 in Treatment of Patients With Premature Ejaculation Multi-Vitamin Tablets, Dapoxetine, Dapoxetine and folic acid. - Premature Ejaculation | Phase 3 | Completed | Sohag University | 120 | 2019-02-10 | 2019-09-11 |
| Evaluate the Neuroprotective Effect of Vitamin B6 and Vitamin B12 Against Vincristine Induced Neurotoxicity in Acute Lymphoblastic Leukaemia Patients Injection Mecobalamin, Tablet Pyridoxine hydrochlorid, Normal saline - Vincristine Induced Neurotoxicity, Acute Lymphoblastic Leukaemia | Phase 2 / Phase 3 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 40 | 2018-03-29 | 2020-07-08 |
| Effect of Folic Acid and Vitamin B12 Supplementation in Subjects With Type 2 Diabetes Folic acid, Vitamin B12, Oral hypoglycemic agents [Metformin +/- Sulfonylurea] - Diabetes Mellitus, Type 2 | Phase 2 / Phase 3 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 80 | 2017-05-01 | 2017-09-19 |
| Vitamin B12 Supplementation During Pregnancy on Cognitive Development cobalamin, placebo - Pregnancy Related, Vitamin B 12 Deficiency | Phase 2 / Phase 3 | Active not recruiting | Centre For International Health | 800 | 2017-03-27 | 2026-04-27 |
| Pemetrexed Maintenance in Patients With Urothelial Carcinoma Who Completed First Line Platinum-based Chemotherapy pemetrexed, Folic Acid, Vitamin B12 Injection - Bladder Cancer, Ureter Cancer | Phase 3 | Unknown | Asan Medical Center | 74 | 2017-01-01 | 2017-06-21 |
| Comparing Efficacy and Safety of CinnaGen Beta Erythropoietin (CinnaPoietin®) Versus Eprex® on the Treatment of Anemia in ESRD Hemodialysis Patients CinnaPoietin®, Eprex®, Nephrovit - Anemia in End-Stage Renal Disease | Phase 3 | Completed | Cinnagen | 156 | 2016-06-22 | 2019-12-18 |
| Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)-Japan Extension Study Pembrolizumab 200 mg, Cisplatin, Carboplatin - Non-Small-Cell Lung Carcinoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 40 | 2016-02-22 | 2024-06-10 |
| Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189) Pembrolizumab 200 mg, Cisplatin, Carboplatin - Non-Small-Cell Lung Carcinoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 616 | 2016-01-15 | 2024-09-20 |
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Carcinoma, Non-Small-Cell Lung (5) · Stroke (4) · Myocardial Infarction (3) · Anemia (2) · Autistic Disorder (2) · Cardiovascular Diseases (2) · Lung Neoplasms (2) · Malnutrition (2) · Vitamin B 12 Deficiency (2) · Abortion, Habitual (1) · Acute Pain (1) · Alzheimer Disease (1) · Atherosclerosis (1) · Avitaminosis (1) · Brain Injuries, Traumatic (1)
Centre For International Health (2) · Merck Sharp & Dohme LLC (2) · National Institute on Aging (NIA) (2) · University of California, San Francisco (2) · AgelessRx (1) · Ain Shams University (1) · All India Institute of Medical Sciences, Bhubaneswar (1) · Asan Medical Center (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Boehringer Ingelheim (1) · Checkpoint Therapeutics, Inc. (1) · Cinnagen (1) · Duta Wacana Christian University (1) · Emory University (1) · Haukeland University Hospital (1)
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Tor A Strand, MD/PhD (2) · Adelfia Urenda-Quezada, MD (1) · Alex Palatnik, MD (1) · Danit R Shahar, RD PhD (1) · Debapriya Bandyopadhyay, M.D. (1) · Dina Badre, MD (1) · Dr Colin P O'Donnell, MB,MRCPsych (1) · Ekkehard Schleussner, Prof. Dr. (1) · Howard N. Hodis, MD (1) · Isabel E Rucker Joerg, MD (1) · Jae-Lyun Lee, MD, PhD (1) · James F. Toole, M.D. (1)
PMID 37465924, PMID 38642841, PMID 11001674, PMID 11844814, PMID 12324494, PMID 12507972, PMID 14699020, PMID 15321804, PMID 15910853, PMID 16543037, PMID 16613998, PMID 16849761, PMID 17645592, PMID 18510727, PMID 18620104, PMID 18714059, PMID 18854539, PMID 19118243, PMID 19125808, PMID 19549699, PMID 19687335, PMID 20484456, PMID 20494665, PMID 21310866, PMID 23734218, PMID 23835707, PMID 23936148, PMID 24055428, PMID 24103380, PMID 24647388, PMID 24885137, PMID 25770690, PMID 25938990, PMID 26722126, PMID 26889605, PMID 26920731, PMID 27418639, PMID 27872106, PMID 28159823, PMID 28184431, PMID 28431557, PMID 28851784, PMID 29325058, PMID 29325121, PMID 29658856, PMID 29771289, PMID 30091209, PMID 30193001, PMID 30253403, PMID 30771856
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