33 completed, 8 unknown, 7 terminated, 4 recruiting. 14 Phase 4, 13 Phase 3, 12 Phase 2, 11 Phase 1, 8 Not applicable.
Follow Valproate: new trials by email Literature Review of Valproate trials Research Report on Valproate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Valproate for the Treatment of Residual Amblyopia Valproate, Placebo, Patch - Amblyopia, Amblyopia Unilateral | Phase 1 / Phase 2 | Recruiting | Boston Children's Hospital | 28 | 2026-07-01 | 2026-07-30 |
| A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) KarXT, Lithium, Valproate - Bipolar Disorder Type I With Mania | Phase 3 | Recruiting | Bristol-Myers Squibb | 450 | 2025-07-18 | 2026-09-14 |
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium Valproate, Quetiapine, Standard of Care - Covid19, Hyperactive Delirium | Phase 4 | Withdrawn | University of Miami | 2023-03-28 | 2023-03-31 | |
| Zolmitriptane as Prophylaxis for Chilhood Migraine zolmitriptanee, topiramate, Valproate - Migraine | Phase 4 | Unknown | Tanta University | 90 | 2023-01-01 | 2023-10-18 |
| Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy Haloperidol, Chlorpromazine, Valproate - Delirium, Epileptics | Phase 2 / Phase 3 | Recruiting | M.D. Anderson Cancer Center | 42 | 2022-07-19 | 2025-11-18 |
| Lithium Versus Anticonvulsants and the Risk of Physical Disorders Lithium - Bipolar Disorder | Completed | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 169285 | 2022-06-01 | 2023-08-22 | |
| Drug-drug Interaction Between Ciprofol and Mefanamic Acid or Valproate Mefanamic Acid, Valproate - Drug Drug Interaction | Phase 1 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 41 | 2021-12-17 | 2022-07-14 |
| Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca Neratinib, Divalproex Sodium - Solid Tumor, Adult | Phase 1 / Phase 2 | Suspended | Virginia Commonwealth University | 80 | 2019-05-01 | 2026-10-21 |
| Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination Therapy sodium valproate with Clozapine, modified electroconvulsive therapy(MECT) with Clozapine, amisulpride with Clozapine - Schizophrenia | Phase 4 | Completed | Shanghai Mental Health Center | 145 | 2018-09-06 | 2022-09-06 |
| Sleep Architecture in Valproate-induced Nocturnal Enuresis in Primary School and Preschool Children. Clinical, EEG and laboratory assessment at presentation, Valproate - Epilepsy, Nocturnal Enuresis | Completed | Mansoura University Hospital | 260 | 2018-09-01 | 2020-05-07 | |
| Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures Levetiracetam, Valproate - Epilepsy, Idiopathic Generalized | Phase 4 | Completed | Mazandaran University of Medical Sciences | 103 | 2018-04-01 | 2022-02-17 |
| Assessment of Valproate on Ethanol Withdrawal Valproate, Lorazepam - Alcohol Dependence, Alcohol Withdrawal Syndrome | Phase 4 | Terminated | CAMC Health System | 3 | 2017-07-11 | 2026-08-18 |
| Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus Phenobarbital, Valproate - Generalized Convulsive Status Epilepticus | Phase 2 | Unknown | Xuanwu Hospital, Beijing | 120 | 2017-02-16 | 2019-07-09 |
| The Optimal Treatment for Treatment-resistant Schizophrenia Risperidone with Clozapine, Aripiprazole with Clozapine, sodium valproate with Clozapine - Schizophrenia | Not applicable | Unknown | Shanghai Mental Health Center | 150 | 2016-11-01 | 2019-03-13 |
| Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies Lithium Carbonate, Lamotrigine, Valproic Acid - Bipolar Disorder | Terminated | University of New Mexico | 1037352 | 2016-09-01 | 2024-03-12 | |
| A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures Valproate - Epilepsy | Phase 1 / Phase 2 | Completed | Cerebral Therapeutics LLC | 6 | 2016-08-01 | 2023-03-16 |
| Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma Stereotactic Radiosurgery, Nivolumab, Valproate - Glioblastoma | Phase 1 | Terminated | University of Virginia | 4 | 2016-05-24 | 2017-05-31 |
| Cytidine- and Creatine-Containing Drug in Treating Bipolar Depression Valproate+Cytidine-+Creatine-, Valproate+Cytidine-, Valproate - Bipolar Depression | Phase 2 | Withdrawn | Ewha Womans University | 2015-12-01 | 2018-02-09 | |
| Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer Dexamethasone, Laboratory Biomarker Analysis, Valproic Acid - Adnexal Mass, Borderline Ovarian Epithelial Tumor | Phase 1 | Completed | Barbara Ann Karmanos Cancer Institute | 50 | 2015-08-01 | 2019-08-14 |
Showing 20 of 56. Sign in to see all of them.
Bipolar Disorder (12) · Mania (5) · Schizophrenia (4) · Epilepsy (3) · Status Epilepticus (3) · Alcoholism (2) · Brain Injuries, Traumatic (2) · Brain Neoplasms (2) · Heart Arrest (2) · Hypoxia, Brain (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Lymphoma (2) · Migraine Disorders (2) · Psychomotor Agitation (2) · Psychotic Disorders (2)
M.D. Anderson Cancer Center (3) · Lund University Hospital (2) · Shanghai Mental Health Center (2) · University of Miami (2) · Washington University School of Medicine (2) · All India Institute of Medical Sciences (1) · Alzheimer's Disease Cooperative Study (ADCS) (1) · Barbara Ann Karmanos Cancer Institute (1) · Boston Children's Hospital (1) · Bristol-Myers Squibb (1) · CAMC Health System (1) · Centre Leon Berard (1) · Cerebral Therapeutics LLC (1) · Eli Lilly and Company (1) · Emory University (1)
United States (26) · China (6) · France (4) · Sweden (4) · Denmark (3) · Italy (3) · Spain (3) · Australia (2) · Austria (2) · Belgium (2) · Canada (2) · Czechia (2) · Egypt (2) · Germany (2) · Hungary (2)
.Vasu Chantarasak, MD (1) · Abeer Salamah, ass prof (1) · Amadeo Alinea (1) · Andree Daigneault, Dr. (1) · Andrew Poklepovic, MD (1) · Audis Bethea, PharmD, BCPS (1) · Ayal Schaffer, Dr. (1) · Barbara Geller, MD (1) · Barry Ruijter, MD (1) · Benjamin Purow, MD (1) · Benny Lafer, Dr. (1) · Boadie W Dunlop, MD (1)
PMID 11765093, PMID 15005752, PMID 15110730, PMID 15330403, PMID 15349007, PMID 15465989, PMID 15541061, PMID 15569893, PMID 15677618, PMID 15723025, PMID 15898966, PMID 15950022, PMID 15960566, PMID 16023735, PMID 16168792, PMID 16176440, PMID 16197928, PMID 16338761, PMID 16339615, PMID 16339616, PMID 16426088, PMID 16448626, PMID 16449473, PMID 16449474, PMID 16552982, PMID 16566627, PMID 16595351, PMID 16635643, PMID 16675760, PMID 16677228, PMID 16816280, PMID 16816301, PMID 16928441, PMID 17007487, PMID 17042830, PMID 17107609, PMID 17335331, PMID 17392295, PMID 17404119, PMID 17582828, PMID 17728418, PMID 18227782, PMID 18399724, PMID 18681768, PMID 19210946, PMID 20148867, PMID 20409444, PMID 21176032, PMID 21360754, PMID 21810649
1RC2AG036535 (1), K08MH001516 (1), K23MH067795 (1), K23NS058669 (1), P30CA022453 (1), R01DA019992 (1), U01MH064846 (1), U01MH064850 (1), U01MH064868 (1), U01MH064869 (1), U01MH064887 (1), U01MH064911 (1), U01MH068847 (1)