28 recruiting, 23 completed, 12 not yet recruiting, 7 unknown. 69 Not applicable, 3 Early Phase 1, 2 Phase 1, 1 Phase 2, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation - PTSD - Post Traumatic Stress Disorder | Early Phase 1 | Not yet recruiting | Wayne State University | 60 | 2027-04-01 | 2026-07-13 |
| Transcutaneous Auricular Stimulation Targeting Enteral Feeding Intolerance Transcutaneous auricular vagus nerve stimulation - Enteral Feeding Intolerance, ICU | Not applicable | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 60 | 2026-10-08 | 2026-10-02 |
| Transcutaneous Regulation for Atrial Prevention in Postoperative Atrial Fibrillation Following OPCAB Transcutaneous Auricular Vagus Nerve Stimulation - Atrial Fibrillation (AF), OPCABG | Not applicable | Not yet recruiting | Ruijin Hospital | 410 | 2026-10-01 | 2026-09-17 |
| Auricular Vagal Neuromodulation for Depression and Anxiety in Substance Use Disorder Transcutaneous Auricular Vagus Nerve Stimulation - Substance Use Disorder (SUD) | Not applicable | Not yet recruiting | Daisy Thompson-Lake | 50 | 2026-10-01 | 2026-09-11 |
| Ear-Vagus Nerve Stimulation and Body Acupuncture for Gut Motility in Elderly ICU Patients Standard Care, Body Acupuncture, Transcutaneous Auricular Vagus Nerve Stimulation - Gastrointestinal Dysfunction, Critical Illness | Not applicable | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 60 | 2026-09-01 | 2026-10-06 |
| The Effect and Mechanism of taVNS in Modulating Human Social Attention taVNS - Healthy Adult, Role of Vagal Stimulation in Oxytocin Release | Not applicable | Recruiting | University of Electronic Science and Technology of China | 120 | 2026-08-01 | 2026-09-01 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Poor Weight-Loss Response to Incretin Receptor Agonists transcutaneous auricular vagus nerve stimulation, Sham - Obesity & Overweight | Not applicable | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 24 | 2026-08-01 | 2026-07-31 |
| Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation - Anxiety, PTSD | Not applicable | Active not recruiting | Tactical Mind Research Coalition, Inc. | 240 | 2026-08-01 | 2026-09-16 |
| TaVNS for Capsaicin-Induced Pain Transcutaneous Auricular Vagus Nerve Stimulation - Pain Management, Capsaicin-Induced Pain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 30 | 2026-07-10 | 2026-07-22 |
| The Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals With Tiletamine Use Disorder Transcutaneous Auricular Vagus Nerve Stimulation, Sham Stimulation - Tiletamine Use Disorder, Substance Use Disorder (SUD) | Not applicable | Not yet recruiting | Shanghai Mental Health Center | 30 | 2026-07-01 | 2026-07-08 |
| Trial of Innovative Fat-loss Focused Approaches in Patients With Class I Obesity: a Comparative Study Tirzepatide, Transcutaneous auricular vagus nerve stimulation - Class I Obesity | Not applicable | Recruiting | National Medical Research Center for Therapy and Preventive Medicine | 120 | 2026-06-29 | 2026-10-08 |
| Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy - Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD) | Not applicable | Active not recruiting | Universidade da Coruña | 46 | 2026-05-25 | 2026-08-07 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Poor Weight-Loss Response to Lifestyle Intervention transcutaneous auricular vagus nerve stimulation, Sham - Obesity & Overweight | Not applicable | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 24 | 2026-05-08 | 2026-06-05 |
| Clinical Application of Vagus Nerve Stimulation Combined With Immunoregulatory T Cells in Alleviating Aromatase Inhibitor-Induced Pain transcutaneous auricular vagus nerve stimulation, sham stimulation - Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS), Breast Cancer | Not applicable | Not yet recruiting | Peking University People's Hospital | 216 | 2026-05-06 | 2026-05-18 |
| Effect of Recording Duration on Heart Rate Variability During taVNS Transcutaneous Auricular Vagus Nerve Stimulation, Sham Stimulation - Healthy Volunteers | Not applicable | Not yet recruiting | Sinop University | 40 | 2026-05-01 | 2026-04-16 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Preventing Acute Kidney Injury in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass Transcutaneous Auricular Vagus Nerve Stimulation, Sham Stimulation - Acute Kidney Injury, Cardiac Surgery | Not applicable | Recruiting | Sir Run Run Shaw Hospital | 152 | 2026-04-27 | 2026-09-10 |
| Can External Vagus Nerve Stimulation Reduce Systemic Levels of Inflammatory Mediators in Duchenne Muscular Dystrophy Patients? Transcutaneous auricular vagus nerve stimulation - Duchenne Muscular Dystrophy (DMD) | Not applicable | Enrolling by invitation | taVNS AB | 20 | 2026-04-13 | 2026-04-24 |
| Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial Transcutaneous auricular vagus nerve stimulation, Sham transcutaneous auricular stimulation - Vagus Nerve Stimulations, Spirometry | Not applicable | Recruiting | SEFA HAKTAN HATIK | 50 | 2026-03-17 | 2026-03-19 |
| Physiotherapy Methods for Fibromyalgia Connective tissue massage, Transcutaneous auricular vagus nerve stimulation - Fibromyalgia | Not applicable | Recruiting | Ankara Yildirim Beyazıt University | 66 | 2026-03-01 | 2026-06-16 |
| Association of VAgus Nerve Stimulation and Treadmill Training for GAit Rehabilitation in DE Novo Parkinson's Disease Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS), Conventional Physical Therapy (cPT) - Idiopathic Parkinson's Disease (PD) | Not applicable | Recruiting | Fondazione Policlinico Universitario Campus Bio-Medico | 60 | 2026-02-14 | 2026-07-16 |
Showing 20 of 77. Sign in to see all of them.
Parkinson Disease (6) · Anxiety Disorders (4) · Depression (4) · Hemiplegia (4) · Ischemic Stroke (3) · Obesity (3) · Substance-Related Disorders (3) · Agnosia (2) · Anhedonia (2) · Cognitive Dysfunction (2) · Dry Eye Syndromes (2) · Fibromyalgia (2) · Inflammation (2) · Insulin Resistance (2) · Overweight (2)
Bahçeşehir University (5) · Medical University of South Carolina (5) · Anhui Medical University (2) · Beijing Tongren Hospital (2) · Cairo University (2) · Fenerbahce University (2) · Indiana University (2) · SEFA HAKTAN HATIK (2) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (2) · The First Affiliated Hospital with Nanjing Medical University (2) · University of Electronic Science and Technology of China (2) · Affiliated Hospital of Jiaxing University (1) · Ankara Yildirim Beyazıt University (1) · Aristotle University Of Thessaloniki (1) · Balnear and Rehabilitation Sanatorium Techirghiol (1)
China (23) · United States (15) · Turkey (Türkiye) (13) · Egypt (3) · Germany (3) · France (2) · Spain (2) · Argentina (1) · Brazil (1) · Canada (1) · Hong Kong (1) · Italy (1) · Romania (1) · Russia (1) · Sweden (1)
Thomas V Nowak, MD (2) · Bashar Badran, PhD (1) · Brian Pinkston, MD, MPH (1) · Cheryl Lowry, MD, MPH (1) · Chia-Hao Ma, MD (1) · Cristin Welle, PhD (1) · David J. Allison, PhD. (1) · Dong-Xin Wang, MD, PhD (1) · Dorothea Jenkins, MD (1) · Fengqiong Yu, MD (1) · Haihong Lian, Doc (1)
PMID 21921156, PMID 22224768, PMID 22496194, PMID 22665702, PMID 23447789, PMID 25576060, PMID 30146041, PMID 32256328, PMID 32289710, PMID 34779542, PMID 35637543, PMID 37329979, PMID 38018736, PMID 38724717, PMID 40074270, PMID 41071520, PMID 41143755, PMID 41332177, PMID 42264522, PMID 42859155
P2CHD086844 (2), 1OT2OD023847-01 (1), P20GM109040 (1), R01DK131091 (1), R41HD104409 (1)