14 completed, 9 recruiting, 7 unknown, 6 not yet recruiting. 39 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 39 | Completed 13, Recruiting 9, Unknown 7, Not yet recruiting 6, Active not recruiting 2, Enrolling by invitation 2 |
Follow Transcranial Alternating Current Stimulation: new trials by email Literature Review of Transcranial Alternating Current Stimulation trials Research Report on Transcranial Alternating Current Stimulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transcranial Alternating Current Stimulation (tACS) Combined With Cognitive Training in Alzheimer's Disease Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation, Individualized Computerized Memory Training - Transcranial Alternating Current Stimulation, Alzheimer Disease (AD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 30 | 2026-09-16 | 2026-09-24 |
| Dual Neuromodulation for Depression: Boosting TMS With tES Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Mersey Care NHS Trust | 60 | 2026-09-01 | 2026-10-19 |
| Applying Neuromodulation to Boost the Efficacy of Motivational Interviewing transcranial alternating current stimulation, sham transcranial alternating current stimulation, Motivational interviewing (MI) - Cannabis Use Disorder | Not applicable | Not yet recruiting | The Mind Research Network | 82 | 2026-08-01 | 2026-08-27 |
| Effect of Different Currents for Transcranial Modulation of the Sensorimotor Corticospinal Pathway in Healthy Subjects Transcranial Alternating Current Stimulation, Transcranial Direct Current Stimulation, Transcranial Random Noise Stimulation (tRNS) - Health Adult Subjects | Not applicable | Enrolling by invitation | Hospital de Clinicas de Porto Alegre | 14 | 2026-07-15 | 2026-09-21 |
| tACS for Working Memory in Schizophrenia transcranial alternating current stimulation, sham stimulation - Schizophrenia, Working Memory | Not applicable | Recruiting | Central South University | 30 | 2026-07-06 | 2026-07-14 |
| Effects of Transcranial Alternating Current Stimulation on Postoperative Anxiety in Patients Undergoing Intraspinal Tumor Resection Transcranial Alternating Current Stimulation, Sham (No Treatment) - Postoperative Anxiety in Patients Undergoing Intraspinal Tumor Resection | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 102 | 2026-07-01 | 2026-07-20 |
| Neuromodulation and fMRI in Neurodegenerative Diseases Study Transcranial Alternating Current Stimulation - Mild Cognitive Impairment, Traumatic Brain Injury | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 30 | 2026-06-01 | 2026-05-01 |
| Transcranial Alternating Current Stimulation to Enhance Mindfulness Therapy in Generalized Anxiety Disorder Synchronous Individualized Alpha-Frequency tACS, Desynchronous Individualized Alpha-Frequency tACS, Sham tACS - Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Central South University | 99 | 2026-06-01 | 2026-06-16 |
| Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals Transcranial direct current stimulation, transcranial alternating current stimulation, Rehabilitation program - Hemorrhagic Stroke, Ischemic Stroke | Not applicable | Recruiting | Mahidol University | 60 | 2026-03-01 | 2026-10-08 |
| Transcranial Alternating Current Stimulation in Frontotemporal Dementia Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation - Transcranial Alternating Current Stimulation, Frontotemporal Dementia (FTD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 30 | 2026-02-03 | 2026-09-24 |
| Transcranial Alternating Current Stimulation for Patients With Mild Alzheimer's Disease II (TRANSFORM-AD II) sham stimulation, transcranial alternating current stimulation - Alzheimer Disease | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 160 | 2025-11-30 | 2025-11-17 |
| Transcranial Alternating Current Stimulation in Lewy Body Dementia Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation - Lewy Body Dementia (LBD), Transcranial Alternating Current Stimulation | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 40 | 2025-10-01 | 2026-09-22 |
| Transcranial Alternating Current Stimulation for Refractory Constipation With Somatic Symptom Disorder Transcranial Alternating Current Stimulation, Placebo - Functional Constipation (FC), Somatic Symptom Disorder (DSM-5) | Not applicable | Recruiting | Xijing Hospital of Digestive Diseases | 60 | 2025-08-20 | 2026-01-09 |
| Temporal Pole Transcranial Alternating Current Stimulation for Children With Autism Spectrum Disorder Transcranial Alternating Current Stimulation, transcranial Temporal Interference Stimulation - Autism Spectrum Disorder | Not applicable | Completed | Fei Li | 36 | 2025-07-01 | 2026-03-25 |
| TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI) Transcranial Alternating Current Stimulation, Sham tACS - Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Centre for Addiction and Mental Health | 20 | 2025-01-02 | 2026-04-13 |
| Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults Transcranial Alternating Current Stimulation, Digital Cognitive Training - Cognitive Dysfunction, Alzheimer Disease | Not applicable | Recruiting | Universidade Federal do Rio de Janeiro | 40 | 2024-12-02 | 2024-12-13 |
| Transcranial Electrical Stimulation Targeting the Cerebellum for the Treatment of Refractory Temporal Lobe Epilepsy Transcranial Alternating Current Stimulation - Transcranial Electrical Stimulation, Temporal Lobe Epilepsy | Not applicable | Unknown | Xijing Hospital | 60 | 2024-06-08 | 2024-08-19 |
| 40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations Transcranial alternating current stimulation, Sham Transcranial alternating current stimulation - Alzheimer Disease, Cognitive Decline | Not applicable | Completed | The National Brain Mapping Laboratory (NBML) | 30 | 2024-06-01 | 2026-03-18 |
| Transcranial Alternating Current Stimulation in Cerebral Palsy (BOOSTTACS) transcranial Alternating Current Stimulation - Cerebral Palsy | Not applicable | Unknown | IRCCS Eugenio Medea | 44 | 2024-04-15 | 2024-04-17 |
| Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease Transcranial alternating current stimulation, Sham transcranial alternating current stimulation - Transcranial Alternating Current Stimulation, Electroencephalography | Not applicable | Unknown | Anhui Medical University | 40 | 2024-03-01 | 2024-08-21 |
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Alzheimer Disease (10) · Cognitive Dysfunction (10) · Dementia (3) · Lewy Body Disease (3) · Anxiety Disorders (2) · Depression (2) · Frontotemporal Dementia (2) · Schizophrenia (2) · Spondylocostal Dysostosis 4, Autosomal Dominant (2) · Autism Spectrum Disorder (1) · Brain Injuries, Traumatic (1) · Breast Neoplasms (1) · Cerebral Palsy (1) · Communication (1) · Communication Disorders (1)
Xuanwu Hospital, Beijing (4) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (3) · University of California, San Francisco (3) · Anhui Medical University (2) · Central South University (2) · The National Brain Mapping Laboratory (NBML) (2) · University of Minnesota (2) · Centre for Addiction and Mental Health (1) · Chinese PLA General Hospital (1) · Fei Li (1) · First Affiliated Hospital of Fujian Medical University (1) · Florida State University (1) · Hospital de Clinicas de Porto Alegre (1) · I.R.C.C.S. Fondazione Santa Lucia (1) · IRCCS Eugenio Medea (1)
China (14) · United States (8) · Italy (5) · Brazil (2) · Canada (1) · Czechia (1) · Germany (1) · Iran (1) · Spain (1) · Switzerland (1) · Thailand (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Theodore Zanto, Ph.D. (3) · Yi Tang, M.D., Ph.D. (3) · Alexander Opitz, PhD (1) · Anne-Lise Giraud, Prof. (1) · Chunbo Li, Ph.D (1) · Jiang Wen (1) · Martina Assogna, MD (1) · Miguel Escalon, MD, MPH (1) · Rogerio Panizzutti, Professor (1) · Sanjeev Kumar, MD (1) · Sonia Bonni, PhD (1) · Wen Li, PhD (1) · Yan Zhang, PhD (1) · Yumeng Ju, PhD (1)
PMID 11976975, PMID 12092785, PMID 12566600, PMID 15753425, PMID 20633386, PMID 21325651, PMID 21396882, PMID 21810890, PMID 22689311, PMID 23963806, PMID 28709880, PMID 29190362, PMID 29593630, PMID 29802866, PMID 31925823, PMID 31991312, PMID 32390797, PMID 32437650, PMID 32891924, PMID 32954522, PMID 32987305, PMID 33205381, PMID 33523098, PMID 33589640, PMID 34601038, PMID 34690147, PMID 34824891, PMID 35248205, PMID 35297483, PMID 35607946, PMID 36054705, PMID 36203748, PMID 36212652, PMID 36698862, PMID 36952070, PMID 36993450, PMID 37092236, PMID 37179566, PMID 37263767, PMID 37873396, PMID 38172519, PMID 39003229, PMID 39136447, PMID 39267112, PMID 39269839, PMID 40532663, PMID 40552996, PMID 40901773, PMID 40948603, PMID 41158535
1UG3DA061594 (1), 2017 (1), R01NS100849 (1), R21AG060335 (1), R21AG062395 (1), RF1MH124909 (1)