| Registry | NCT07689786 |
|---|---|
| Status | Not yet recruiting |
| Study type | Observational |
| Enrollment | 36 (Estimated) |
| Sponsor | Mustafa Kemal University (Other) |
| Conditions | Gingivitis; Chronic |
| Interventions | Miswak, Toothpaste (Combination product, other) |
| Dates | start 2026-07-04 (estimated), primary completion 2027-07-04 (estimated), completion 2027-07-04 (estimated), first posted 2026-07-08, last updated 2026-07-08 |
| Locations | 2 sites in Turkey (Türkiye) |
Related Papers Related Patents Related Grants Related Experts
All trials for Gingivitis; Chronic All trials of Miswak All trials of Toothpaste
This pilot study aims to evaluate the effects of miswak use on the oral biological environment by comparing biochemical parameters obtained from saliva and dental plaque samples collected from individuals who use miswak and controls. A total of 36 healthy volunteers will be enrolled in the study, including 18 miswak+rutine oral hygiene products users and 18 rutine oral hygiene products.
Periodontal clinical parameters will be recorded, and saliva and supragingival dental plaque samples will be collected from all participants. The collected samples will be analysed for biomarkers associated with periodontal inflammation and oxidative stress. Interleukin-1 beta (IL-1β), C-reactive protein (CRP), and oxidative stress levels will be measured using biochemical analysis.
The findings of this study are expected to provide preliminary evidence regarding the biological effects of miswak on oral health and contribute to the current understanding of its potential role as an adjunctive oral hygiene tool.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Test Group: Miswak using | Combination Product: Miswak; Other: Toothpaste | Participants received oral hygiene instructions and used a manual toothbrush twice daily in combination with miswak (Salvadora persica L.) five times daily for one month before periodontal treatment. Clinical periodontal parameters will be recorded, and salivary IL-1β, CRP, and oxidative stress levels will be evaluated at pre-op (4 weeks), baseline (before periodontal treatment), and post-op (6 weeks). | |
| control group | Other: Toothpaste | articipants with gingivitis received oral hygiene instructions and used a manual toothbrush twice daily without miswak. Clinical periodontal parameters will be recorded, and salivary IL-1β, CRP, and oxidative stress levels will be evaluated at pre-op (4 weeks), baseline (before periodontal treatment), and post-op (6 weeks). |
Sex: All, ages: 18 Years to 60 Years, accepts healthy volunteers
Inclusion Criteria: * To be in the age range of 18-60 years * To have no systemic disease * To be diagnosed with gingivitis Exclusion Criteria: * Smoking * History of recent periodontal treatment
| Facility | City | Country | Status |
|---|---|---|---|
| Hatay Mustafa Kemal University | Antakya, Hatay | Turkey (Türkiye) | |
| Hatay Mustafa Kemal Üniversitesi | Hatay | Turkey (Türkiye) |