8 completed, 2 not yet recruiting, 1 withdrawn. 4 Phase 2, 3 Not applicable, 2 Phase 4, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 2, Not yet recruiting 2 |
| Not applicable | 3 | Completed 2, Withdrawn 1 |
| Phase 4 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow thiamine hydrochloride: new trials by email Literature Review of thiamine hydrochloride trials Research Report on thiamine hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| THiamine for Recovery In Vulnerable Early-life Infections thiamine hydrochloride 100 mg, Placebo - Meningitis, Bacteremia | Phase 2 | Not yet recruiting | Milton S. Hershey Medical Center | 240 | 2026-12-01 | 2026-10-09 |
| Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents thiamine hydrochloride 100 mg - Major Depressive Disorder (MDD), Thiamine | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2026-10-01 | 2026-08-28 |
| Iron and Immune Response to Vaccine (IRONMUM) Sangobion and Thiamine Hydrochloride, Sangobion, Thiamine hydrochloride and Vitamin B12 - Pregnancy Related | Not applicable | Completed | University of Oxford | 171 | 2022-06-18 | 2026-03-24 |
| Thiamine as a Renal Protective Agent in Septic Shock Thiamine Hydrochloride, Placebo - Sepsis, Kidney Injury | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 95 | 2018-09-04 | 2023-06-27 |
| Vitamin C, Thiamine, and Steroids in Sepsis Vitamin C, Thiamine, Hydrocortisone - Sepsis | Phase 3 | Completed | Emory University | 501 | 2018-08-22 | 2021-04-13 |
| Thiamine Supplementation in High Risk Cardiac Surgery Patients Thiamine hydrochloride (200mg) dissolved in 100 ml of normal saline, Normal saline (100ml) - Cardiac Surgery | Phase 4 | Completed | Meshalkin Research Institute of Pathology of Circulation | 40 | 2017-10-19 | 2018-06-27 |
| High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation Thiamine, Normal saline - Hematopoietic Stem Cell Transplantation, Delirium | Phase 2 | Completed | UNC Lineberger Comprehensive Cancer Center | 66 | 2017-10-16 | 2021-10-19 |
| Optimum Thiamine Intervention (OpTIn) Trial Thiamine Hydrochloride - Wernicke-Korsakoff Syndrome | Phase 4 | Completed | Menzies School of Health Research | 334 | 2014-09-01 | 2019-08-16 |
| Pharmacokinetics of Thiamine in Breastfeeding Mothers and Infants thiamine hydrochloride 100 mg - Beriberi | Phase 1 | Completed | Mayo Clinic | 24 | 2012-01-01 | 2013-05-29 |
| A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs Thiamine hydrochloride, Riboflavin, Ascorbic acid - HIV Infections | Not applicable | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2015-06-04 | ||
| Vitamin B Therapy for Hyperlactatemia Thiamine hydrochloride, Riboflavin - HIV Infections | Not applicable | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 225 | 2011-02-28 |
Thiamine Deficiency (3) · HIV Infections (2) · Sepsis (2) · Bacteremia (1) · Beriberi (1) · Delirium (1) · Depressive Disorder, Major (1) · Korsakoff Syndrome (1) · Meningitis (1) · Neurologic Manifestations (1) · Psychological Well-Being (1) · Recurrence (1) · Renal Insufficiency (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · Beth Israel Deaconess Medical Center (1) · Emory University (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Menzies School of Health Research (1) · Meshalkin Research Institute of Pathology of Circulation (1) · Milton S. Hershey Medical Center (1) · UNC Lineberger Comprehensive Cancer Center (1) · University of Oxford (1)
United States (7) · Australia (1) · Cambodia (1) · Russia (1) · Thailand (1)
Ari Moskowitz, MD (1) · Christopher Pilcher (1) · Donald Rosenstein, MD (1) · Grace McComsey (1) · Hal Drakesmith, Dr. (1) · Jonathan Sevransky, MD, MHS (1) · Kylie Dingwall, PhD (1) · Mark Topazian, M.D. (1) · Zev Nakamura, MD (1)
PMID 15076242, PMID 23864540, PMID 30953543, PMID 31801567, PMID 32007132, PMID 32317004, PMID 33620405, PMID 33945982, PMID 36853612, PMID 37364280, PMID 38321529
R01HD122957 (1)