14 completed, 3 withdrawn, 1 active not recruiting, 1 recruiting. 20 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 14, Withdrawn 3, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow Therapy: new trials by email Literature Review of Therapy trials Research Report on Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies Psychotherapy, Psilocybin, Survey Administration - Anxiety, Depression | Phase 2 | Active not recruiting | University of Washington | 16 | 2026-05-19 | 2026-10-29 |
| A Multi-Site Study of MDMA-Assisted Psychotherapy for Eating Disorders Midomafetamine, Non-directive therapy, Therapy - Anorexia Nervosa Restricting Type, Binge-Eating Disorder | Phase 2 | Withdrawn | Resilient Pharmaceuticals | 2026-02-01 | 2024-10-31 | |
| Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIV Ketamine, Psychotherapy - Methamphetamine Use Disorder | Phase 2 | Completed | Nicky Mehtani, MD, MPH | 17 | 2025-03-04 | 2026-08-12 |
| MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder 3,4-methylenedioxymethamphetamine, d-amphetamine, Therapy - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Stephen Robert Marder | 40 | 2025-03-01 | 2026-08-19 |
| Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in Veterans Midomafetamine, Therapy - PTSD | Phase 2 | Withdrawn | Resilient Pharmaceuticals | 2023-09-01 | 2024-10-30 | |
| Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD midomafetamine, Therapy - Posttraumatic Stress Disorder | Phase 2 | Withdrawn | Resilient Pharmaceuticals | 2022-08-01 | 2024-11-01 | |
| Treating Smokers With Mental Illness Nicotine patch, Nicotine lozenge, Therapy - Smoking Cessation, Cigarette Smoking | Phase 2 | Completed | University of Minnesota | 38 | 2019-03-01 | 2021-05-25 |
| MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSD MDMA, CBCT, Therapy - Posttraumatic Stress Disorder | Phase 1 / Phase 2 | Completed | Resilient Pharmaceuticals | 12 | 2016-07-03 | 2025-06-04 |
| MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening Illness Midomafetamine HCl, Placebo, Therapy - Anxiety | Phase 2 | Completed | Resilient Pharmaceuticals | 18 | 2015-05-14 | 2025-06-05 |
| Molecularly Targeted Therapy in Treating Patients With BRAF Wild-type Melanoma That is Metastatic cytology specimen collection procedure, MEK 162 therapy or molecularly targeted therapy, therapeutic procedure - Recurrent Melanoma, Stage IIIA Melanoma | Phase 2 | Completed | Yale University | 49 | 2014-05-01 | 2020-01-02 |
| Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults Placebo, Midomafetamine HCl, Therapy - Social Anxiety in Autistic Adults | Phase 2 | Completed | Resilient Pharmaceuticals | 12 | 2014-04-11 | 2025-06-05 |
| PPARĪ³ Agonist Treatment for Cocaine Dependence Pioglitazone, Placebo, Therapy - Cocaine Use Disorder, Alcohol Use Disorder | Phase 1 / Phase 2 | Completed | The University of Texas Health Science Center, Houston | 30 | 2012-08-01 | 2018-04-26 |
| Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial Midomafetamine, Therapy - Posttraumatic Stress Disorder | Phase 2 | Completed | Resilient Pharmaceuticals | 3 | 2010-12-15 | 2024-01-24 |
| Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder Low dose MDMA-assisted therapy, Medium dose MDMA-assisted therapy, Full dose MDMA-assisted therapy - Posttraumatic Stress Disorder | Phase 2 | Completed | Resilient Pharmaceuticals | 26 | 2010-11-10 | 2025-06-05 |
| Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Cognitive-behavioral therapy, Treatment as Usual - Autism, Asperger's Syndrome | Phase 2 / Phase 3 | Completed | University of South Florida | 45 | 2010-04-01 | 2013-04-02 |
| Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related Anxiety 200 mcg LSD, 20 mcg LSD, Therapy - Anxiety | Phase 2 | Completed | Multidisciplinary Association for Psychedelic Studies | 12 | 2008-02-01 | 2023-07-12 |
| Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder 3,4-methylenedioxymethamphetamine (125 mg), 3,4-methyelendioxymethamphetamine (25 mg), Therapy - Posttraumatic Stress Disorder | Phase 2 | Completed | Resilient Pharmaceuticals | 14 | 2006-09-13 | 2024-07-15 |
| Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals D-Amphetamine 30mg, D-Amphetamine 60mg, Modafinil 200mg - Cocaine-Related Disorders | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 73 | 2006-03-01 | 2017-06-21 |
| MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder Midomafetamine HCl, Lactose placebo pill, Therapy - Posttraumatic Stress Disorder | Phase 2 | Completed | Resilient Pharmaceuticals | 23 | 2004-03-12 | 2025-06-06 |
| Unrelated Donor Transplant for Malignant and Non-Malignant Disorders UDAlloSCT, Therapy - Leukemia, Lymphoma | Phase 2 | Terminated | Columbia University | 22 | 2002-11-01 | 2015-04-15 |
Stress Disorders, Post-Traumatic (8) · Anxiety Disorders (4) · Autistic Disorder (2) · Alcoholism (1) · Anxiety, Separation (1) · Asperger Syndrome (1) · Binge-Eating Disorder (1) · Bipolar Disorder (1) · Bone Marrow Failure Disorders (1) · Chemsex (1) · Chronic Pain (1) · Cigarette Smoking (1) · Cocaine-Related Disorders (1) · Depression (1) · Depressive Disorder, Major (1)
Resilient Pharmaceuticals (10) · The University of Texas Health Science Center, Houston (2) · Columbia University (1) · Multidisciplinary Association for Psychedelic Studies (1) · Nicky Mehtani, MD, MPH (1) · Stephen Robert Marder (1) · University of Minnesota (1) · University of South Florida (1) · University of Washington (1) · Yale University (1)
United States (15) · Switzerland (2)
Michael C Mithoefer, MD (2) · Michael Mithoefer, MD (2) · Adele Lafrance, PhD (1) · Anthony Back, MD (1) · Charles S. Grob, MD (1) · Chris Stauffer, MD (1) · Devon Christie, MD (1) · Eric A Storch, Ph.D. (1) · Harry Lando, PhD (1) · Joy M Schmitz, PhD (1) · Joy M. Schmitz, PhD (1) · Mitchell S Cairo, MD (1) · Nicky Mehtani, MD MPH (1) · Patricia LoRusso, D.O. (1) · Peter Gasser, MD (1)
PMID 31065731, PMID 31572236, PMID 32500209, PMID 20643699, PMID 22969732, PMID 23118021, PMID 23172889, PMID 23357440, PMID 24594678, PMID 25818246, PMID 29728331, PMID 30196397, PMID 33235285, PMID 33593332, PMID 38174611, PMID 40850924
P50DA009262 (2), 2KL2TR001870 (1), P30CA022453 (1)