20 completed, 4 terminated, 4 unknown, 2 active not recruiting. 33 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 33 | Completed 20, Terminated 4, Unknown 4, Active not recruiting 2, Recruiting 2, Withdrawn 1 |
| Phase 2 | 4 | Completed 2, Recruiting 1, Withdrawn 1 |
Follow Therapeutic Conventional Surgery: new trials by email Literature Review of Therapeutic Conventional Surgery trials Research Report on Therapeutic Conventional Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer Biopsy Procedure, Biospecimen Collection, Cisplatin - Renal Pelvis and Ureter Urothelial Carcinoma | Phase 2 / Phase 3 | Recruiting | National Cancer Institute (NCI) | 131 | 2021-11-12 | 2026-10-30 |
| Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma Extended Release Flucytosine, NovoTTF-100A Device, Quality-of-Life Assessment - Anaplastic Astrocytoma, Glioblastoma | Phase 2 / Phase 3 | Withdrawn | NRG Oncology | 2020-01-31 | 2026-05-07 | |
| Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) Autologous Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Aspiration and Biopsy - Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular | Phase 3 | Recruiting | Children's Oncology Group | 750 | 2018-05-14 | 2026-08-25 |
| Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer Ipilimumab, Local Consolidation Therapy, Nivolumab - Lung Adenocarcinoma, Lung Non-Small Cell Carcinoma | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 339 | 2017-12-29 | 2026-09-18 |
| Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Doxorubicin, Doxorubicin Hydrochloride, Ifosfamide - Alveolar Soft Part Sarcoma, Angiomatoid Fibrous Histiocytoma | Phase 2 / Phase 3 | Completed | National Cancer Institute (NCI) | 140 | 2014-08-12 | 2026-06-17 |
| Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab With or Without Estrogen Deprivation in Treating Patients With Hormone Receptor-Positive, HER2-Positive Operable or Locally Advanced Breast Cancer Aromatase Inhibition Therapy, Carboplatin, Cytology Specimen Collection Procedure - HER2-Positive Breast Carcinoma, Hormone Receptor-Positive Breast Carcinoma | Phase 3 | Completed | National Cancer Institute (NCI) | 315 | 2014-02-18 | 2026-10-06 |
| Surgery With or Without Internal Radiation Therapy Compared With Stereotactic Body Radiation Therapy in Treating Patients With High-Risk Stage I Non-Small Cell Lung Cancer therapeutic conventional surgery, iodine I 125, stereotactic body radiation therapy - Lung Cancer | Phase 3 | Terminated | Alliance for Clinical Trials in Oncology | 13 | 2011-05-01 | 2017-05-30 |
| Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer Carboplatin, Laboratory Biomarker Analysis, Paclitaxel - Esophageal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 3 | Completed | National Cancer Institute (NCI) | 203 | 2011-02-14 | 2026-06-02 |
| Paclitaxel and Carboplatin With or Without Bevacizumab in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer Bevacizumab, Carboplatin, Computed Tomography - Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 692 | 2010-09-27 | 2026-05-29 |
| Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer bevacizumab, cetuximab, FOLFIRI regimen - Colorectal Cancer | Phase 3 | Terminated | Alliance for Clinical Trials in Oncology | 340 | 2010-08-01 | 2024-12-27 |
| Immediate Surgery or Surgery After Sunitinib Malate in Treating Patients With Metastatic Kidney Cancer timing of surgery, gene expression analysis, biologic sample preservation procedure - Kidney Cancer | Phase 3 | Unknown | European Organisation for Research and Treatment of Cancer - EORTC | 99 | 2010-04-01 | 2017-02-08 |
| Trastuzumab or Lapatinib Ditosylate in Treating Women With Early Breast Cancer trastuzumab, lapatinib ditosylate, laboratory biomarker analysis - Breast Cancer | Phase 3 | Unknown | Institute of Cancer Research, United Kingdom | 257 | 2010-04-01 | 2018-09-17 |
| Chemotherapy With or Without Surgery in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery systemic chemotherapy, adjuvant therapy, quality-of-life assessment - Colorectal Cancer | Phase 2 / Phase 3 | Completed | University College London Hospitals | 500 | 2010-01-01 | 2013-08-26 |
| Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Cisplatin, Dexrazoxane, Doxorubicin Hydrochloride - PRETEXT I Hepatoblastoma, PRETEXT II Hepatoblastoma | Phase 3 | Completed | National Cancer Institute (NCI) | 236 | 2009-09-15 | 2026-06-30 |
| Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Dactinomycin, Doxorubicin Hydrochloride, Radiation Therapy - Adult Kidney Wilms Tumor, Beckwith-Wiedemann Syndrome | Phase 3 | Completed | Children's Oncology Group | 249 | 2009-08-24 | 2026-06-03 |
| Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylate imatinib mesylate, therapeutic conventional surgery - Gastrointestinal Stromal Tumor | Phase 3 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 12 | 2009-05-01 | 2012-09-24 |
| Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Nonmetastatic Breast Cancer bevacizumab, cyclophosphamide, docetaxel - Breast Cancer, Cardiac Toxicity | Phase 3 | Unknown | Cambridge University Hospitals NHS Foundation Trust | 800 | 2009-04-01 | 2010-03-25 |
| PET/CT Scan-Guided Watchful Waiting or Neck Dissection of Locally Advanced Lymph Node Metastases in Treating Patients Undergoing Chemotherapy and Radiation Therapy for Primary Head And Neck Cancer positron emission tomography/computed tomography, therapeutic conventional surgery - Head and Neck Cancer | Phase 3 | Unknown | Warwick Medical School | 560 | 2007-09-01 | 2013-08-26 |
| Radiation Therapy or Surgery in Treating Patients Receiving Chemotherapy for Bladder Cancer therapeutic conventional surgery, radiation therapy - Bladder Cancer | Phase 3 | Completed | Institute of Cancer Research, United Kingdom | 45 | 2007-07-01 | 2019-01-04 |
| Combination Chemotherapy and Paclitaxel Plus Trastuzumab in Treating Women With Palpable Breast Cancer That Can Be Removed by Surgery Cyclophosphamide, Epirubicin Hydrochloride, Laboratory Biomarker Analysis - HER2/Neu Positive, Stage IA Breast Cancer | Phase 3 | Completed | National Cancer Institute (NCI) | 280 | 2007-07-01 | 2019-01-23 |
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Breast Neoplasms (8) · Carcinoma, Non-Small-Cell Lung (3) · Sarcoma (3) · Adenocarcinoma of Lung (2) · Cardiotoxicity (2) · Chondrosarcoma, Extraskeletal Myxoid (2) · Colonic Neoplasms (2) · Colorectal Neoplasms (2) · Dermatofibrosarcoma (2) · Fibrosarcoma (2) · Histiocytoma, Malignant Fibrous (2) · Inflammatory Breast Neoplasms (2) · Leiomyosarcoma (2) · Liposarcoma (2) · Lung Neoplasms (2)
National Cancer Institute (NCI) (9) · Children's Oncology Group (8) · Alliance for Clinical Trials in Oncology (4) · European Organisation for Research and Treatment of Cancer - EORTC (3) · Gynecologic Oncology Group (2) · Institute of Cancer Research, United Kingdom (2) · Cambridge University Hospitals NHS Foundation Trust (1) · M.D. Anderson Cancer Center (1) · NRG Oncology (1) · University College London Hospitals (1) · Warwick Medical School (1)
United States (24) · Canada (10) · Puerto Rico (9) · United Kingdom (7) · Australia (6) · New Zealand (4) · Italy (3) · Switzerland (3) · Israel (2) · Netherlands (2) · Belgium (1) · Brazil (1) · France (1) · Ireland (1) · Japan (1)
Aaron R Weiss (1) · Alessandro Gronchi (1) · Alexander Stojadinovic, MD (1) · Aman Buzdar (1) · Armando E. Giuliano, MD (1) · Austin Obichere, MD (1) · Axel Bex (1) · Carola Arndt (1) · Cornelis Van De Velde (1) · David Ashley (1) · Elizabeth A Mullen (1) · Emiel JT Rutgers (1) · Gary Strauss (1) · Geertjan Van Tienhoven (1) · Helena Earl, MBBS, PhD, FRCP (1)
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