173 completed, 80 terminated, 31 active not recruiting, 27 unknown. 169 Phase 2, 77 Phase 1, 55 Not applicable, 33 Phase 3, 24 Early Phase 1.
Follow Therapeutic Conventional Surgery: new trials by email Literature Review of Therapeutic Conventional Surgery trials Research Report on Therapeutic Conventional Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma Doxorubicin, Doxorubicin Hydrochloride, Drug Delivery Microdevice - Metastatic Sarcoma, Recurrent Sarcoma | Not applicable | Recruiting | M.D. Anderson Cancer Center | 20 | 2025-02-25 | 2026-08-11 |
| A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery Near Infrared Imaging, Therapeutic Conventional Surgery, Tozuleristide - Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8 | Phase 1 / Phase 2 | Terminated | University of Washington | 8 | 2024-04-17 | 2026-09-16 |
| Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive Lung, Colorectal, or Pancreatic Cancer Binimetinib, Palbociclib, Therapeutic Conventional Surgery - Colorectal Carcinoma, Lung Adenocarcinoma | Early Phase 1 | Withdrawn | Roswell Park Cancer Institute | 2024-01-15 | 2023-12-22 | |
| Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial Radiation Therapy, Radiosurgery, Stereotactic Biopsy - Malignant Glioma | Phase 1 | Recruiting | Mayo Clinic | 28 | 2023-05-23 | 2026-09-30 |
| Testing the Addition of an Anti-Cancer Immunotherapy Drug, Avelumab, to Gemcitabine and Carboplatin Chemotherapy Prior to Surgery in Muscle Invasive Urinary Tract Cancer vs. Surgery Alone in Patients Who Are Not Able to Receive Cisplatin Therapy (SWOG GAP TRIAL) Therapeutic Conventional Surgery, Avelumab, Gemcitabine Hydrochloride - Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall, Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma | Phase 2 | Terminated | SWOG Cancer Research Network | 6 | 2022-08-10 | 2024-12-30 |
| Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer therapeutic conventional surgery, laboratory biomarker analysis, quality-of-life assessment - Oropharynx Cancer | Phase 2 | Recruiting | Heath Skinner | 150 | 2022-07-20 | 2026-07-21 |
| Neoadj Admin Autologous Tumor Infiltrating Lymphocytes & Pembrolizumab for Treatment of Adv Melanoma Patients Cyclophosphamide, Fludarabine, Lifileucel - Locally Advanced Melanoma, Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Phase 1 | Active not recruiting | Richard Wu | 2 | 2022-07-01 | 2026-02-24 |
| Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer Biopsy, Therapeutic Conventional Surgery, Uniformly-labeled [13C]glucose - Pancreatic Ductal Adenocarcinoma | Not applicable | Recruiting | Rutgers, The State University of New Jersey | 16 | 2022-03-14 | 2026-05-04 |
| Atezolizumab Before Surgery for the Treatment of Regionally Metastatic Head and Neck Squamous Cell Cancer With an Unknown or Historic Primary Site Atezolizumab, Radiation Therapy, Therapeutic Conventional Surgery - Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck | Phase 2 | Terminated | University of California, Davis | 1 | 2021-12-07 | 2026-06-05 |
| Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer Biopsy Procedure, Biospecimen Collection, Cisplatin - Renal Pelvis and Ureter Urothelial Carcinoma | Phase 2 / Phase 3 | Recruiting | National Cancer Institute (NCI) | 131 | 2021-11-12 | 2026-10-30 |
| AL101 Before Surgery for the Treatment of Notch Activated Adenoid Cystic Cancer AL101, Therapeutic Conventional Surgery - Adenoid Cystic Carcinoma, Metastatic Adenoid Cystic Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 13 | 2021-09-30 | 2026-06-24 |
| Testing the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy Treatment During Radiation Therapy for Superior Sulcus Non-small Cell Lung Cancer Atezolizumab, Biopsy, Biospecimen Collection - Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2021-09-09 | 2023-09-26 | |
| Effects of Probiotics on the Gut Microbiome and Immune System in Operable Stage I-III Breast or Lung Cancer Biopsy, Biospecimen Collection, Probiotic - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Early Phase 1 | Completed | Mayo Clinic | 6 | 2021-07-01 | 2023-04-21 |
| Swallowing Outcomes and Circulating Tumor DNA in Patients With HPV Related Oropharyngeal Cancer Treated With Transoral Surgery and Reduced Intensity Adjuvant Therapy Transoral Surgery, External Beam Radiation Therapy, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Active not recruiting | Rutgers, The State University of New Jersey | 15 | 2021-05-19 | 2026-08-14 |
| Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer Quality-of-Life Assessment, Questionnaire Administration, Selpercatinib - Malignant Thyroid Gland Neoplasm, Poorly Differentiated Thyroid Gland Carcinoma | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 30 | 2021-02-26 | 2026-05-20 |
| Improving Patient-Centered Communication in Breast Cancer Through Patient and Provider Interventions Decision Aid iCanDecide - ESE website, Decision Aid iCanDecide - S website, Therapeutic Conventional Surgery - Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | Not applicable | Active not recruiting | Alliance for Clinical Trials in Oncology | 614 | 2021-02-16 | 2026-10-27 |
| Atezolizumab and Bevacizumab Before Surgery for the Treatment of Resectable Liver Cancer Atezolizumab, Bevacizumab, Therapeutic Conventional Surgery - Resectable Hepatocellular Carcinoma, Stage I Hepatocellular Carcinoma AJCC v8 | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 16 | 2021-02-10 | 2026-09-14 |
| Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer Anastrozole, Therapeutic Conventional Surgery, Trastuzumab Deruxtecan - Early-stage Breast Cancer, Hormone Receptor Positive Breast Carcinoma | Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 88 | 2020-10-09 | 2025-11-10 |
| Feasibility Study of Anatomical Modeling for Image Guided Thoracic Surgery Computed Tomography, Therapeutic Conventional Surgery - Lung Neoplasm | Not applicable | Completed | M.D. Anderson Cancer Center | 3 | 2020-09-16 | 2024-10-28 |
| Bintrafusp Alfa Before Surgery for the Treatment of Untreated Resectable Non-small Cell Lung Cancer Bintrafusp Alfa, Therapeutic Conventional Surgery - Resectable Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 2 | Terminated | M.D. Anderson Cancer Center | 2 | 2020-08-05 | 2022-07-28 |
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Breast Neoplasms (63) · Glioblastoma (29) · Carcinoma, Non-Small-Cell Lung (26) · Brain Neoplasms (25) · Gliosarcoma (22) · Rectal Neoplasms (22) · Colorectal Neoplasms (19) · Lung Neoplasms (18) · Squamous Cell Carcinoma of Head and Neck (18) · Astrocytoma (17) · Glioma (17) · Carcinoma, Intraductal, Noninfiltrating (16) · Sarcoma (16) · Carcinoma, Renal Cell (15) · Oligodendroglioma (15)
National Cancer Institute (NCI) (68) · M.D. Anderson Cancer Center (29) · Mayo Clinic (15) · City of Hope Medical Center (14) · Alliance for Clinical Trials in Oncology (13) · Children's Oncology Group (12) · Roswell Park Cancer Institute (12) · University of Washington (11) · Case Comprehensive Cancer Center (9) · Gynecologic Oncology Group (9) · University of Southern California (7) · Jonsson Comprehensive Cancer Center (6) · Wake Forest University Health Sciences (6) · OHSU Knight Cancer Institute (5) · Ohio State University Comprehensive Cancer Center (5)
United States (292) · Canada (22) · United Kingdom (18) · Puerto Rico (10) · Australia (9) · France (9) · Italy (7) · Switzerland (7) · New Zealand (5) · Netherlands (4) · South Korea (4) · Germany (3) · Israel (3) · Japan (3) · Belgium (2)
Rodabe N Amaria (3) · Adam Luginbuhl, MD (2) · Chi Lin (2) · Christopher Ryan (2) · David H. Ilson, MD, PhD (2) · Evanthia Galanis (2) · Jana Portnow (2) · Joanne Mortimer (2) · Joseph Sparano (2) · Judy Boughey, MD (2) · Nadia N. Laack, M.D. (2) · Padmanee Sharma (2) · Saranya Chumsri (2) · Simon Gollins, MD (2) · Stephen Michael Hahn (2)
PMID 32827353, PMID 36648215, PMID 34028986, PMID 13129630, PMID 16164916, PMID 16192820, PMID 16514477, PMID 19636002, PMID 20038733, PMID 20063546, PMID 20300966, PMID 20309640, PMID 20975250, PMID 21406089, PMID 21555689, PMID 21755378, PMID 21791687, PMID 22293631, PMID 22347360, PMID 22614181, PMID 22795435, PMID 22868365, PMID 23139259, PMID 23228299, PMID 23332384, PMID 23380277, PMID 23522754, PMID 23620404, PMID 23664013, PMID 23969788, PMID 24047116, PMID 24101169, PMID 24239210, PMID 24314307, PMID 24338498, PMID 24470557, PMID 24562448, PMID 24779680, PMID 24821582, PMID 24901360, PMID 24982463, PMID 25150172, PMID 25421877, PMID 25439688, PMID 25532471, PMID 25646192, PMID 25664534, PMID 25926352, PMID 25975632, PMID 26450920
U10CA098543 (12), U10CA027469 (8), U10CA180868 (8), P30CA008748 (7), P30CA015083 (7), P30CA015704 (7), P30CA016672 (7), U10CA180886 (7), P30CA072720 (6), P30CA012197 (5), P30CA016056 (5), P30CA033572 (5), P30CA014089 (4), P30CA022453 (4), P30CA036727 (4)