11 completed, 6 recruiting, 5 unknown, 4 not yet recruiting. 25 Not applicable, 1 Early Phase 1, 1 Phase 1, 1 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| tACS and Upper Limb Rehabilitation in Chronic Stroke tACS, Sham - Stroke | Not applicable | Not yet recruiting | National University Hospital, Singapore | 34 | 2026-12-01 | 2026-08-21 |
| Dual Neuromodulation for Depression: Boosting TMS With tES Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Mersey Care NHS Trust | 60 | 2026-09-01 | 2026-10-19 |
| Applying Neuromodulation to Boost the Efficacy of Motivational Interviewing transcranial alternating current stimulation, sham transcranial alternating current stimulation, Motivational interviewing (MI) - Cannabis Use Disorder | Not applicable | Not yet recruiting | The Mind Research Network | 82 | 2026-08-01 | 2026-08-27 |
| Effect of Different Currents for Transcranial Modulation of the Sensorimotor Corticospinal Pathway in Healthy Subjects Transcranial Alternating Current Stimulation, Transcranial Direct Current Stimulation, Transcranial Random Noise Stimulation (tRNS) - Health Adult Subjects | Not applicable | Enrolling by invitation | Hospital de Clinicas de Porto Alegre | 14 | 2026-07-15 | 2026-09-21 |
| Enhancing Attention in Elderly Using a Brain-Computer-Interface transcranial electrical stimulation, Mindfulness Meditation - Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | University of Texas at Austin | 100 | 2026-07-01 | 2026-07-27 |
| Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) in Adolescents With First-episode Depression Who Are Drug-naive: A Randomized, Double-blind, Controlled Pilot Study tACS - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | First Affiliated Hospital of Chongqing Medical University | 30 | 2025-10-01 | 2025-09-22 |
| Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) Combined With Stable Medication in Adolescents With Depression tACS - Depression - Major Depressive Disorder | Not applicable | Recruiting | First Affiliated Hospital of Chongqing Medical University | 30 | 2025-10-01 | 2026-10-05 |
| tES Modalities for the Treatment of ADHD transcranial electrical stimulation - Attention Deficit Disorder With Hyperactivity, Neurodevelopmental Disorders | Not applicable | Completed | The National Brain Mapping Laboratory (NBML) | 45 | 2025-03-30 | 2026-08-04 |
| TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI) Transcranial Alternating Current Stimulation, Sham tACS - Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Centre for Addiction and Mental Health | 20 | 2025-01-02 | 2026-04-13 |
| Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression tACS, Control - Major Depressive Disorder | Not applicable | Unknown | Xuanwu Hospital, Beijing | 40 | 2024-01-31 | 2024-01-31 |
| Non-Invasive Brain Stimulation and Cognitive Training for Depressive Symptomatology Related to Breast Cancer (ONCODEP) Transcranial Direct Current Stimulation, Transcranial Alternating Current Stimulation, tES sham - Depressive Symptoms, Cognitive Impairment | Not applicable | Active not recruiting | University of Santiago de Compostela | 82 | 2023-09-27 | 2025-07-20 |
| Neurostimulation for the Treatment of Post-Stroke Aphasia tACS - Post-stroke Aphasia | Not applicable | Recruiting | QVITI S.A. | 64 | 2023-09-06 | 2026-02-18 |
| A Study for the Disrupted Interpersonal Interaction Among Gaming Disorder Individuals and Treatment tACS - Gaming Disorder | Not applicable | Recruiting | Shanghai Mental Health Center | 60 | 2023-09-01 | 2024-01-17 |
| Transcranial Direct/ Alternating Current Stimulation for Parkinson's Disease Treatment tACS, tDCS, sham - tACS, tDCS | Not applicable | Completed | Anhui Medical University | 60 | 2023-02-15 | 2024-05-10 |
| Neuromodulation of Motion Illusions (Vection) non-invasive neuromodulation, electroencephalography, anatomical MRI - Healthy | Not applicable | Unknown | University Hospital, Grenoble | 90 | 2022-01-30 | 2022-01-20 |
| Targeting Individual Alpha Frequencies to Enhance Perceptual Timing Transcranial alternating current stimulation - Psychosis, Schizophrenia | Completed | University of Minnesota | 11 | 2021-11-01 | 2023-02-14 | |
| Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition tACS, TMS, TIS - Mild Cognitive Impairment, Healthy Aging | Not applicable | Unknown | Masaryk University | 160 | 2021-09-01 | 2023-05-25 |
| Mechanism of Action of tACS for the Treatment of MDD tACS, Sham tACS - Major Depressive Disorder, MDD | Not applicable | Completed | University of North Carolina, Chapel Hill | 20 | 2021-06-09 | 2024-09-19 |
| Atlas of Intracranial Recordings on Cortical Responses After Functional tACS tACS - Transcranial Alternating Current Stimulation | Phase 1 / Phase 2 | Unknown | Xuanwu Hospital, Beijing | 30 | 2020-09-20 | 2020-09-23 |
| Transcranial Alternating Current Stimulation (tACS) in Aphasia tACS - Aphasia, Stroke | Not applicable | Recruiting | Medical College of Wisconsin | 50 | 2020-01-04 | 2026-07-29 |
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Cognitive Dysfunction (4) · Depression (4) · Depressive Disorder, Major (4) · Stroke (3) · Language (2) · Memory Disorders (2) · Aphasia (1) · Attention Deficit Disorder with Hyperactivity (1) · Breast Neoplasms (1) · Chronic Pain (1) · Communication (1) · Communication Disorders (1) · Dementia (1) · Language Disorders (1) · Low Back Pain (1)
University of North Carolina, Chapel Hill (5) · First Affiliated Hospital of Chongqing Medical University (2) · Xuanwu Hospital, Beijing (2) · Anhui Medical University (1) · Centre for Addiction and Mental Health (1) · Chinese University of Hong Kong (1) · Hospital de Clinicas de Porto Alegre (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Masaryk University (1) · Medical College of Wisconsin (1) · Mersey Care NHS Trust (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · National University Hospital, Singapore (1) · QVITI S.A. (1) · Shanghai Mental Health Center (1)
United States (10) · China (5) · Brazil (1) · Canada (1) · Czechia (1) · France (1) · Germany (1) · Hong Kong (1) · Iran (1) · Singapore (1) · Spain (1) · United Kingdom (1)
Flavio Frohlich, PhD (3) · Bernhard A Sabel, Prof. Dr. (1) · David Rubinow, MD (1) · Effie Chew, MBBS (1) · Friedhelm C. Hummel (1) · G.G. Zhao (1) · Irena Rektorova (1) · Junjie Bu, Professor (1) · Karen McCulloch, PhD, DPT (1) · Leonardo G Cohen, M.D. (1) · Miguel Escalon, MD, MPH (1) · Priyanka Shah-Basak, PhD (1)
PMID 23497551, PMID 24005242, PMID 25692174, PMID 26782765, PMID 30979801, PMID 31282938, PMID 33211157, PMID 34969856, PMID 35940423, PMID 37339227, PMID 37682331, PMID 38476648, PMID 38880208, PMID 27355577, PMID 30268803, PMID 31849514, PMID 34029378, PMID 37468529, PMID 40154492
R01MH101547 (2), 1UG3DA061594 (1), R01MH111889 (1)