2 completed, 2 unknown, 1 active not recruiting, 1 terminated. 6 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 2, Unknown 2, Active not recruiting 1, Terminated 1 |
| Phase 2 | 1 | Unknown 1 |
Follow Surface-Active Agents: new trials by email Literature Review of Surface-Active Agents trials Research Report on Surface-Active Agents
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Daily Chlorexidine Bath for Health Care Associated Infection Prevention 2% chlorhexidine digluconate solution with surface-active agents, Usual Baths - Health Care Associated Infection, Ventilator Associated Pneumonia | Phase 3 | Completed | Hospital do Coracao | 15730 | 2022-08-03 | 2024-06-13 |
| The Budesonide in Babies (BiB) Trial budesonide (Pulmicort nebulizing suspension)., surfactant (poractant alfa;Curosurf) - Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome | Phase 3 | Active not recruiting | NICHD Neonatal Research Network | 642 | 2021-04-01 | 2026-04-15 |
| Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome surfactant, surfactant+vitamin A - RDS, Infant, Newborn | Phase 3 | Unknown | Third Military Medical University | 100 | 2012-01-01 | 2011-07-26 |
| Surfactant Positive Airway Pressure and Pulse Oximetry Trial Surfactant, Continuous Positive Airway Pressure (CPAP), Supplemental oxygen with target saturation of 85 to 89% - Infant, Newborn, Diseases, Other Preterm Infants | Phase 3 | Completed | NICHD Neonatal Research Network | 1316 | 2005-02-01 | 2019-04-18 |
| The Use of Surfactant in Lung Transplantation: A Randomized Control Pilot Study Surfactant (calfactant) - Lung Transplantation, Primary Graft Dysfunction | Phase 2 / Phase 3 | Unknown | Rabin Medical Center | 42 | 2005-01-01 | 2007-07-25 |
| Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome Lucinactant, Standard Care - Meconium Aspiration | Phase 3 | Terminated | Windtree Therapeutics | 69 | 2000-03-01 | 2012-05-03 |
Bronchopulmonary Dysplasia (2) · Premature Birth (2) · Cross Infection (1) · Infant, Newborn, Diseases (1) · Meconium Aspiration Syndrome (1) · Pneumonia, Ventilator-Associated (1) · Primary Graft Dysfunction (1) · Rare Diseases (1) · Respiratory Distress Syndrome (1) · Respiratory Tract Diseases (1) · Retinopathy of Prematurity (1)
NICHD Neonatal Research Network (2) · Hospital do Coracao (1) · Rabin Medical Center (1) · Third Military Medical University (1) · Windtree Therapeutics (1)
United States (3) · Brazil (1) · China (1) · Israel (1)
Abbot R. Laptook, MD (1) · Abhik Das, PhD (1) · Alexandre B Cavalcanti, M.D (1) · Barbara J. Stoll, MD (1) · Brenda B. Poindexter, MD MS (1) · Bruno M Tomazini, M.D (1) · Edward F. Bell, MD (1) · Kathleen A. Kennedy, MD MPH (1) · Krisa P. Van Meurs, MD (1) · Kristi L. Watterberg, MD (1) · Kurt Schibler, MD (1) · Michele C. Walsh, MD MS (1) · MordechaI R Kramer, Prof (1) · Namasivayam Ambalavanan, MD (1)
PMID 20472937, PMID 20472939, PMID 20587676, PMID 22371462, PMID 22738947, PMID 23268664, PMID 24725582, PMID 24876196, PMID 25425651, PMID 25554820, PMID 27344218, PMID 28279433, PMID 28600154, PMID 30292492, PMID 30692613, PMID 35715492, PMID 37640232, PMID 40571094, PMID 41026481, PMID 41732706
M01RR000633 (1), M01RR000750 (1), M01RR008084 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD027851 (1), U10HD027853 (1), U10HD027856 (1), U10HD027871 (1), U10HD027880 (1), U10HD027904 (1), U10HD034216 (1), U10HD036790 (1)