29 completed, 10 unknown, 7 recruiting, 4 terminated. 15 Phase 2, 14 Phase 1, 13 Phase 4, 10 Phase 3, 9 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade Naloxone Hydrochloride, Fentanyl, Sterile Saline - Fentanyl Overdose, Fentanyl Poisoning | Phase 2 | Recruiting | Clear Scientific, Inc. | 16 | 2026-05-28 | 2026-08-24 |
| Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease Irrisept (0.05% chlorhexidine gluconate), Normal Saline - Pilonidal Disease | Not applicable | Recruiting | Yosef Nasseri, MD | 60 | 2026-02-17 | 2026-03-27 |
| A Single-Dose Study to Evaluate Safety and Efficacy of CS-1103 in Participants Receiving a Single Dose of Methamphetamine Methamphetamine, Sterile Saline, CS-1103 - Methamphetamine Intoxication, Methamphetamine Disorders | Phase 2 | Recruiting | Clear Scientific, Inc. | 40 | 2026-02-05 | 2026-10-21 |
| Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine Nicardipine, Sterile Saline - Coronary Artery Disease | Early Phase 1 | Withdrawn | Thomas Jefferson University | 2025-12-01 | 2024-04-26 | |
| Intralesional Gardasil-9 for the Treatment of Recalcitrant Warts 9-valent human papillomavirus vaccine, Sterile Saline - Warts, Verruca (Warts) | Phase 2 | Active not recruiting | Rush University Medical Center | 55 | 2025-09-02 | 2026-09-15 |
| Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury Angiotensin (1-7), Sterile saline - Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | University of Arizona | 90 | 2024-05-28 | 2026-08-11 |
| HepB mAb19 in Individuals With Chronic Hepatitis B Infection HepB mAb19, Sterile Saline - Hepatitis b Virus, Hepatitis B | Phase 1 | Active not recruiting | Rockefeller University | 37 | 2024-04-25 | 2026-10-13 |
| Efficacy of Transversus Abdominis Plane Block for Laparoscopic Cholecystectomy Abdominal Wall Block, Surgical infiltration, Sterile saline - Pain, Postoperative | Phase 3 | Withdrawn | Boston Children's Hospital | 2024-03-01 | 2024-07-08 | |
| A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants CS-1103, Sterile Saline - Substance Use Disorders, Methamphetamine Abuse | Phase 1 | Completed | Clear Scientific, Inc. | 32 | 2024-02-07 | 2025-11-10 |
| A Study of Sterile Saline Infusion in Healthy Volunteers Sterile Saline - Healthy Volunteers | Early Phase 1 | Completed | Janssen Research & Development, LLC | 32 | 2024-01-12 | 2025-05-23 |
| GLS-1200 Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery GLS-1200, Placebo - Sinusitis Chronic | Phase 2 | Unknown | GeneOne Life Science, Inc. | 99 | 2023-12-01 | 2023-01-11 |
| Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery Morphine Sulfate, Placebo - Pain, Postoperative | Phase 4 | Recruiting | Northwestern University | 90 | 2023-09-29 | 2026-06-09 |
| A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy 3BNC117-LS, 10-1074-LS, Sterile Saline - HIV-1 | Phase 1 | Active not recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 105 | 2023-07-26 | 2026-10-01 |
| A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction Soludronate®, sterile saline - Bone Loss, Alveolar | Phase 3 | Unknown | Xeolas Pharmaceuticals Limited | 60 | 2022-11-22 | 2024-09-19 |
| Surgiphor vs Saline Joints Surgiphor Irrigation Solution, Sterile saline - Prosthetic-joint Infection | Not applicable | Unknown | Center for Innovation and Research Organization | 868 | 2022-09-19 | 2023-09-11 |
| Randomized Controlled Trial Comparing Irrisept Versus Normal Saline for Wound Irrigation After Posterior Spine Surgery saline 0.9%, (0.05% chlorhexidine gluconate (CHG) in sterile water) - Lumbar Spine Degeneration, Cervical Spine Degeneration | Phase 4 | Withdrawn | University of Missouri-Columbia | 2022-07-01 | 2022-12-27 | |
| Evaluation of Botox Treatment on Chronical Scrotal Pain Botulinum toxin type A, Sterile saline - Scrotum Disease, Chronic Pain | Phase 4 | Unknown | Nicolai Skov Schiellerup | 50 | 2022-06-01 | 2022-04-20 |
| Can Testosterone Accelerate Injury Recovery After Arthroscopic Rotator Cuff Repair Testosterone cypionate, Placebos - Rotator Cuff Tears | Phase 2 / Phase 3 | Withdrawn | Orthopedic Institute, Sioux Falls, SD | 2021-08-01 | 2022-03-15 | |
| Vaginal Microbiota Transplant Vaginal microbiome transplant, Oral Metronidazole, Sterile saline - Recurrent Bacterial Vaginosis | Phase 1 / Phase 2 | Recruiting | Douglas Kwon | 62 | 2021-04-22 | 2026-09-11 |
| A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries. saline 0.9%, Liposomal bupivacaine - Lumbar Spine Degeneration | Phase 4 | Completed | University of Missouri-Columbia | 34 | 2021-02-10 | 2023-06-13 |
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Pain, Postoperative (5) · Agnosia (3) · Heart Failure (2) · Infertility (2) · Influenza, Human (2) · Pain (2) · Wound Infection (2) · Abortion, Habitual (1) · Acquired Immunodeficiency Syndrome (1) · Alveolar Bone Loss (1) · Antisocial Personality Disorder (1) · Arthritis, Rheumatoid (1) · Brain Diseases (1) · Brain Injuries, Traumatic (1) · Breast Neoplasms (1)
Clear Scientific, Inc. (3) · McMaster University (3) · University of Missouri-Columbia (3) · Center for Human Reproduction (2) · Northwestern University (2) · Rockefeller University (2) · Assiut University (1) · Boston Children's Hospital (1) · Bowdoin College (1) · C. Michael Gibson, MS, MD (1) · C. R. Bard (1) · Center for Innovation and Research Organization (1) · Children's Hospital of Philadelphia (1) · Columbia University (1) · Daniela Francescato Veiga (1)
United States (41) · Brazil (2) · Canada (2) · Denmark (2) · Mozambique (2) · Philippines (2) · Uganda (2) · Cameroon (1) · China (1) · Egypt (1) · France (1) · Germany (1) · India (1) · Kenya (1) · Lebanon (1)
David H Barad, MD, MS (2) · Don Kim Moore, MD (2) · Marina Caskey, MD (2) · Norbert Gleicher, MD (2) · Xinhua Li, Ph.D. (2) · Amy Paller, MD (1) · C. Michael Gibson, MS, MD (1) · Carol A Tamminga, MD (1) · Charles E Davis, M.D. (1) · Charles F. von Reyn, MD (1) · Daniela F Veiga, MD, PhD (1) · Daryl S Paulsen, PhD (1) · Dennis McDaid, PhD (1) · Doug Kwon, MD, PhD (1)
PMID 11130605, PMID 11840097, PMID 12177541, PMID 12925248, PMID 15220782, PMID 17413463, PMID 18242337, PMID 18758356, PMID 21167790, PMID 21841518, PMID 22067774, PMID 22227789, PMID 23388191, PMID 23392233, PMID 23706046, PMID 24436846, PMID 24666860, PMID 24885519, PMID 24916651, PMID 25282071, PMID 25996534, PMID 26090281, PMID 26424336, PMID 27515308, PMID 27566242, PMID 27599329, PMID 28498853, PMID 28962912, PMID 29018407, PMID 29102751, PMID 29685114, PMID 29845327, PMID 30059778, PMID 30933856, PMID 31120957, PMID 31562530, PMID 31870492, PMID 32335895, PMID 32769643, PMID 33345865, PMID 33492696, PMID 34357396, PMID 35218370, PMID 35432170, PMID 36307361, PMID 36400089, PMID 36649086, PMID 40857697, PMID 41887240, PMID 8867249
5UG3DA059286 (1), R01MH087721 (1), R44NS063485 (1), U01DA053054 (1), U01DA058548 (1)