8 completed, 2 active not recruiting, 2 recruiting, 2 terminated. 14 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 14 | Completed 8, Active not recruiting 2, Recruiting 2, Terminated 2 |
| Phase 2 | 3 | Recruiting 2, Completed 1 |
Follow Sterile saline: new trials by email Literature Review of Sterile saline trials Research Report on Sterile saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury Angiotensin (1-7), Sterile saline - Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | University of Arizona | 90 | 2024-05-28 | 2026-08-11 |
| HepB mAb19 in Individuals With Chronic Hepatitis B Infection HepB mAb19, Sterile Saline - Hepatitis b Virus, Hepatitis B | Phase 1 | Active not recruiting | Rockefeller University | 37 | 2024-04-25 | 2026-10-13 |
| A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants CS-1103, Sterile Saline - Substance Use Disorders, Methamphetamine Abuse | Phase 1 | Completed | Clear Scientific, Inc. | 32 | 2024-02-07 | 2025-11-10 |
| A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy 3BNC117-LS, 10-1074-LS, Sterile Saline - HIV-1 | Phase 1 | Active not recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 105 | 2023-07-26 | 2026-10-01 |
| Vaginal Microbiota Transplant Vaginal microbiome transplant, Oral Metronidazole, Sterile saline - Recurrent Bacterial Vaginosis | Phase 1 / Phase 2 | Recruiting | Douglas Kwon | 62 | 2021-04-22 | 2026-09-11 |
| Safety and Efficacy of FURESTEM-RA Inj. in Patients With Moderate to Severe Rheumatoid Arthritis FURESTEM-RA Inj, sterile saline - Rheumatoid Arthritis | Phase 1 / Phase 2 | Completed | Kang Stem Biotech Co., Ltd. | 33 | 2018-07-11 | 2022-10-10 |
| Efficacy of Buprenorphine on Postoperative Endodontic Analgesia Buprenorphine, Sterile saline, lidocaine, epinephrine (Local anesthetic) - Postoperative Pain | Phase 1 | Terminated | University Hospitals Cleveland Medical Center | 10 | 2017-04-01 | 2019-04-23 |
| 3BNC117 and 10-1074 in HIV-infected Individuals 3BNC117, 10-1074, Analytical treatment interruption - Human Immunodeficiency Virus (HIV) | Phase 1 | Completed | Rockefeller University | 34 | 2016-06-01 | 2018-08-21 |
| A Safety and Immunogenicity Trial of IHV01 300 ug FLSC vaccine, 150 ug FLSC vaccine, 75 ug FLSC vaccine - HIV Infection | Phase 1 | Completed | University of Maryland, Baltimore | 65 | 2015-11-01 | 2021-12-16 |
| 21 Day Cumulative Skin Irritation of RUT058-60 Hypochlorous acid solution 106 mg/L, 0.1% (w/v) Sodium Lauryl Sulfate, 0.9% Physiological Saline, USP - Irritation/Irritant | Phase 1 | Completed | Pulmatrix Inc. | 43 | 2014-07-01 | 2016-02-04 |
| Phase I Trial of DAR-901 DAR-901, BCG, Sterile saline - Tuberculosis | Phase 1 | Completed | Dartmouth-Hitchcock Medical Center | 59 | 2014-02-01 | 2016-08-02 |
| Use of Autologous Bone Marrow Aspirate Concentrate in Painful Knee Osteoarthritis Autologous Bone Marrow Aspirate Concentrate, Sterile saline - Bilateral Primary Osteoarthritis of Knee | Phase 1 | Completed | Mayo Clinic | 25 | 2013-08-01 | 2017-05-05 |
| Vasopressin Effects on Human Social Communication Vasopressin, Arginine, ADH, Placebo; Sterile Saline - Healthy | Phase 1 | Completed | Bowdoin College | 225 | 2011-09-01 | 2017-11-06 |
| Nitric Oxide, LPS and the Pathogenesis of Asthma Phase II LPS endotoxin - Healthy | Phase 1 | Terminated | John Sundy | 70 | 2003-04-01 | 2013-07-16 |
Acquired Immunodeficiency Syndrome (1) · Agnosia (1) · Antisocial Personality Disorder (1) · Arthritis, Rheumatoid (1) · Brain Injuries, Traumatic (1) · Diabetes Insipidus (1) · HIV Infections (1) · Hepatitis B (1) · Osteoarthritis (1) · Pain, Postoperative (1) · Substance-Related Disorders (1) · Tuberculosis (1) · Vaginosis, Bacterial (1)
Rockefeller University (2) · Bowdoin College (1) · Clear Scientific, Inc. (1) · Dartmouth-Hitchcock Medical Center (1) · Douglas Kwon (1) · John Sundy (1) · Kang Stem Biotech Co., Ltd. (1) · Mayo Clinic (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Pulmatrix Inc. (1) · University Hospitals Cleveland Medical Center (1) · University of Arizona (1) · University of Maryland, Baltimore (1)
United States (13) · Germany (1) · South Korea (1)
Marina Caskey, MD (2) · Charles E Davis, M.D. (1) · Charles F. von Reyn, MD (1) · Doug Kwon, MD, PhD (1) · John C Sundy, M.D. PhD (1) · John Pullman, M.D. (1) · Magnotti Louis, MD (1) · Michael C Sneller, M.D. (1) · Richmond Thompson, Ph.D. (1) · Shane Shapiro, MD (1)
PMID 27515308, PMID 27566242, PMID 28498853, PMID 29018407, PMID 29685114, PMID 31120957
R01MH087721 (1), U01DA053054 (1)