7 active not recruiting, 3 terminated, 2 completed, 2 recruiting. 15 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Active not recruiting 7, Terminated 3, Completed 2, Recruiting 2, Unknown 1 |
| Phase 2 | 1 | Completed 1 |
Follow stereotactic radiotherapy: new trials by email Literature Review of stereotactic radiotherapy trials Research Report on stereotactic radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 562 | 2027-03-09 | 2026-10-13 |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases Brain Surgery, Quality-of-Life Assessment, Questionnaire Administration - Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | NRG Oncology | 237 | 2022-10-24 | 2026-09-10 |
| Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma | Phase 3 | Terminated | NRG Oncology | 19 | 2021-08-05 | 2026-05-20 |
| Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability Biospecimen Collection, Magnetic Resonance Imaging, Memantine Hydrochloride - Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | NRG Oncology | 152 | 2021-06-08 | 2026-09-14 |
| Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors Conventional Surgery, Questionnaire Administration, Stereotactic Radiosurgery - Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Recruiting | Mayo Clinic | 140 | 2018-11-19 | 2026-08-19 |
| Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery - Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 180 | 2018-11-08 | 2026-08-10 |
| Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival Stereotactic Body Radiotherapy, Surgery - Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma | Phase 2 / Phase 3 | Completed | NRG Oncology | 129 | 2014-12-24 | 2026-07-10 |
| Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Cyclophosphamide, Doxorubicin, Doxorubicin Hydrochloride - Metastatic Ewing Sarcoma, Metastatic Malignant Neoplasm in the Bone | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 312 | 2014-12-12 | 2026-10-22 |
| Sorafenib Tosylate With or Without Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer Sorafenib, stereotactic body radiation therapy - Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 193 | 2013-04-01 | 2026-01-28 |
| Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases Cognitive Assessment, Quality-of-Life Assessment, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 88 | 2012-08-02 | 2026-09-16 |
| Stereotactic Radiation in Vestibular Schwannoma stereotactic radiotherapy, stereotactic radiosurgery - Vestibular Schwannoma | Phase 3 | Unknown | Ramathibodi Hospital | 200 | 2011-10-01 | 2011-10-10 |
| Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 132 | 2009-08-13 | 2026-08-11 |
| Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer stereotactic radiotherapy, primary surgery - Lung Cancer | Phase 3 | Terminated | Amsterdam UMC, location VUmc | 22 | 2008-10-01 | 2022-03-17 |
| Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy, Erlotinib Hydrochloride, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Recurrent Non-Small Cell Lung Carcinoma | Phase 3 | Terminated | National Cancer Institute (NCI) | 126 | 2004-10-06 | 2018-03-09 |
Brain Neoplasms (9) · Lung Neoplasms (4) · Breast Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (3) · Neoplasm Metastasis (3) · Carcinoma, Renal Cell (2) · Melanoma (2) · Small Cell Lung Carcinoma (2) · Carcinoma, Hepatocellular (1) · Gastrointestinal Neoplasms (1) · Lymphatic Metastasis (1) · Neoplasms (1) · Neuroma, Acoustic (1) · Sarcoma, Ewing (1)
NRG Oncology (5) · M.D. Anderson Cancer Center (3) · National Cancer Institute (NCI) (2) · Amsterdam UMC, location VUmc (1) · Mayo Clinic (1) · Radiation Therapy Oncology Group (1) · Ramathibodi Hospital (1) · SWOG Cancer Research Network (1)
United States (13) · Canada (8) · Hong Kong (3) · South Korea (2) · Australia (1) · Ireland (1) · Japan (1) · Netherlands (1) · Puerto Rico (1) · Saudi Arabia (1)
Vinai Gondi (2) · Debra N Yeboa (1) · Debra NAna Yeboa (1) · Elizabeth Yan, M.D. (1) · Jing Li (1) · Laura Dawson (1) · Mariya Rozenblit (1) · Paul Sperduto (1) · Putipun Puataweepong, M.D. (1) · Rupesh R Kotecha (1) · Steven G DuBois (1) · Steven J Chmura (1) · Stuart H Burri (1)
PMID 28687375, PMID 33668061, PMID 35602670, PMID 36669140, PMID 37289451, PMID 37717787, PMID 38475765, PMID 39699905, PMID 40531511, PMID 42208702
U10CA180868 (4), U10CA021661 (2), P30CA016672 (1), U10CA098543 (1), U10CA180886 (1), U10CA180888 (1), UG1CA189867 (1)