23 completed, 22 active not recruiting, 22 unknown, 15 terminated. 34 Not applicable, 31 Phase 2, 26 Phase 1, 15 Phase 3, 2 Early Phase 1.
Follow stereotactic radiotherapy: new trials by email Literature Review of stereotactic radiotherapy trials Research Report on stereotactic radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 562 | 2027-03-09 | 2026-10-13 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| Study Comparing Neoadjuvant Versus Adjuvant Stereotactic Radiotherapy of Brain Metastases stereotactic radiotherapy, Excision surgery - Brain Metastases, Adult | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 68 | 2026-09-01 | 2026-08-25 |
| A Study to Assess the Ability of Stereotactic Radiotherapy to Restore the Efficacy of Immunotherapy in Patients With Metastatic Cancer. Stereotactic Radiotherapy - Metastatic Cancer | Not applicable | Recruiting | Elsan | 35 | 2026-01-27 | 2026-04-23 |
| Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases Furmonertinib, Intrathecal chemotherapy, Stereotactic radiotherapy - Non Small Cell Lung Cancer | Phase 2 | Recruiting | Tianjin Medical University Cancer Institute and Hospital | 30 | 2025-12-22 | 2025-12-26 |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| Stereotactic Radiotherapy of Prostate Cancer With Reduction of Safety Margins Stereotactic radiotherapy - Prostate Cancer (Adenocarcinoma) | Not applicable | Recruiting | University Hospital Ostrava | 100 | 2024-11-01 | 2024-11-12 |
| Immunosensitized Radiotherapy Combined With Evoximab (AK112) and Chemotherapy Neoadjuvant Therapy for Stage II-III Non-small Cell Lung Cancer Stereotactic radiotherapy, Evoximab, Pemetrexed - Stereotactic Radiotherapy; Evoximab (AK112); New Adjuvant Therapy for Non-small Cell Lung Cancer | Phase 2 | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 44 | 2024-04-30 | 2024-04-30 |
| An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer Behavioral Dietary Intervention, Text Message-Based Navigation Intervention, Internet-Based Intervention - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Not applicable | Terminated | Thomas Jefferson University | 1 | 2023-12-13 | 2026-03-03 |
| SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI EGFR-TK Inhibitor, Stereotactic radiotherapy - Brain Metastases, Non-small Cell Lung Cancer | Phase 2 | Active not recruiting | Fudan University | 202 | 2023-08-10 | 2025-09-15 |
| Lu-PSMA and Stereotactic Radiotherapy Versus Radiotherapy Alone for Prostate Cancer (LUST) [177Lu]Lu-PSMA I&T, Stereotactic Radiotherapy - Prostate Cancer | Phase 2 | Recruiting | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | 70 | 2023-06-27 | 2025-12-03 |
| Cardiac RadiothErapy for VEntricular Tachycardia Stereotactic radiotherapy - Ventricular Tachycardia | Not applicable | Unknown | Universitaire Ziekenhuizen KU Leuven | 5 | 2023-05-23 | 2023-08-03 |
| Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria) Immunotherapy, Stereotactic Radiosurgery, Vertebroplasty - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 200 | 2023-03-27 | 2026-04-09 |
| Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis Whole-brain radiotherapy - Carcinoma, Non-Small-Cell Lung, Brain Metastases | Unknown | Xiaorong Dong | 50 | 2023-02-13 | 2023-02-21 | |
| Efficacy and Safety of SBRT Combined With Cardonilizumab and Lenvastinib in the Treatment of Unresectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus Cadonilimab, Stereotactic radiotherapy, Renvatinib - Hepatocellular Carcinoma Non-resectable, Portal Vein Tumor Thrombus | Phase 1 / Phase 2 | Unknown | First Affiliated Hospital of Guangxi Medical University | 30 | 2023-02-02 | 2023-09-15 |
| Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases Brain Surgery, Quality-of-Life Assessment, Questionnaire Administration - Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | NRG Oncology | 237 | 2022-10-24 | 2026-09-10 |
| Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases Ipilimumab, Nivolumab, Pembrolizumab - Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary | Phase 1 | Terminated | Emory University | 1 | 2022-10-13 | 2026-04-23 |
| Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife Hippocampal-sparing, Stereotactic radiosurgery - Brain Metastases, Radiosurgery | Phase 2 | Unknown | Ottawa Hospital Research Institute | 70 | 2022-04-01 | 2022-02-16 |
| SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial Questionnaire Administration, Stereotactic Radiosurgery, Magnetic Resonance Imaging - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 2 | Recruiting | Mayo Clinic | 90 | 2022-03-14 | 2026-10-01 |
| Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases Stereotactic Radiation, AGuIX gadolinium-based nanoparticles, Placebo - Brain Cancer, Brain Metastases | Phase 2 | Recruiting | Brigham and Women's Hospital | 134 | 2021-09-15 | 2026-09-09 |
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Brain Neoplasms (35) · Carcinoma, Non-Small-Cell Lung (17) · Melanoma (11) · Breast Neoplasms (9) · Neoplasm Metastasis (9) · Lung Neoplasms (8) · Prostatic Neoplasms (8) · Carcinoma, Renal Cell (7) · Pancreatic Neoplasms (7) · Carcinoma, Hepatocellular (6) · Neoplasms (4) · Small Cell Lung Carcinoma (4) · Gastrointestinal Neoplasms (3) · Breast Neoplasms, Male (2) · Carcinoma, Ovarian Epithelial (2)
M.D. Anderson Cancer Center (9) · NRG Oncology (6) · National Cancer Institute (NCI) (6) · Case Comprehensive Cancer Center (5) · Emory University (4) · Jonsson Comprehensive Cancer Center (3) · Mayo Clinic (3) · Peking University Third Hospital (3) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (3) · Amsterdam UMC, location VUmc (2) · Centre Francois Baclesse, Luxembourg (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Stanford University (2) · Sunnybrook Health Sciences Centre (2) · Universitaire Ziekenhuizen KU Leuven (2)
United States (58) · Canada (15) · China (10) · France (6) · Netherlands (5) · Hong Kong (3) · Italy (3) · South Korea (3) · Australia (2) · Belgium (2) · Czechia (2) · Denmark (2) · Luxembourg (2) · Ireland (1) · Japan (1)
Jing Li (5) · Vinai Gondi (2) · Xuezhang Duan, MD (2) · Zuping Lian, MD (2) · Alfredo Urdaneta, M.D. (1) · Amar Kishan (1) · Amol J Ghia (1) · An Nulens (1) · Anwen Liu (1) · Ayal Aizer, MD, MHS (1) · Bently Doonan, MD, MS (1) · Bing Lu (1) · Chengfeng Wang, B.A. (1) · Cheryl Ho, MD, FRCPC (1) · Chi Lin (1)
PMID 110740, PMID 11134209, PMID 12192016, PMID 12393820, PMID 15001240, PMID 16029795, PMID 16360786, PMID 16437480, PMID 16698099, PMID 18351348, PMID 19706802, PMID 20072824, PMID 20233825, PMID 2168190, PMID 22397654, PMID 22649764, PMID 23332384, PMID 25538019, PMID 25559415, PMID 25605582, PMID 25701298, PMID 25819287, PMID 26028407, PMID 2616812, PMID 26412456, PMID 26829933, PMID 27242967, PMID 28271869, PMID 28586960, PMID 28598415, PMID 28630212, PMID 28687375, PMID 29449659, PMID 29566762, PMID 2990668, PMID 30612961, PMID 30825970, PMID 31227373, PMID 31285677, PMID 31891135, PMID 32083739, PMID 32307017, PMID 32349020, PMID 32464155, PMID 32580883, PMID 32736936, PMID 33450821, PMID 33668061, PMID 33885704, PMID 34530092
U10CA180868 (6), U10CA021661 (4), P30CA016672 (3), P30CA138292 (3), P30CA043703 (2), 2014 (1), 2017 (1), N01CM00039 (1), P30CA006973 (1), P30CA013330 (1), P30CA015704 (1), P30CA016059 (1), P30CA036727 (1), P30CA056036 (1), P30CA124435 (1)