9 active not recruiting, 6 completed, 6 unknown, 5 recruiting. 31 Phase 2, 9 Phase 1, 1 Phase 3.
Follow Stereotactic radiotherapy: new trials by email Literature Review of Stereotactic radiotherapy trials Research Report on Stereotactic radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases Furmonertinib, Intrathecal chemotherapy, Stereotactic radiotherapy - Non Small Cell Lung Cancer | Phase 2 | Recruiting | Tianjin Medical University Cancer Institute and Hospital | 30 | 2025-12-22 | 2025-12-26 |
| Immunosensitized Radiotherapy Combined With Evoximab (AK112) and Chemotherapy Neoadjuvant Therapy for Stage II-III Non-small Cell Lung Cancer Stereotactic radiotherapy, Evoximab, Pemetrexed - Stereotactic Radiotherapy; Evoximab (AK112); New Adjuvant Therapy for Non-small Cell Lung Cancer | Phase 2 | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 44 | 2024-04-30 | 2024-04-30 |
| SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI EGFR-TK Inhibitor, Stereotactic radiotherapy - Brain Metastases, Non-small Cell Lung Cancer | Phase 2 | Active not recruiting | Fudan University | 202 | 2023-08-10 | 2025-09-15 |
| Lu-PSMA and Stereotactic Radiotherapy Versus Radiotherapy Alone for Prostate Cancer (LUST) [177Lu]Lu-PSMA I&T, Stereotactic Radiotherapy - Prostate Cancer | Phase 2 | Recruiting | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | 70 | 2023-06-27 | 2025-12-03 |
| Efficacy and Safety of SBRT Combined With Cardonilizumab and Lenvastinib in the Treatment of Unresectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus Cadonilimab, Stereotactic radiotherapy, Renvatinib - Hepatocellular Carcinoma Non-resectable, Portal Vein Tumor Thrombus | Phase 1 / Phase 2 | Unknown | First Affiliated Hospital of Guangxi Medical University | 30 | 2023-02-02 | 2023-09-15 |
| Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife Hippocampal-sparing, Stereotactic radiosurgery - Brain Metastases, Radiosurgery | Phase 2 | Unknown | Ottawa Hospital Research Institute | 70 | 2022-04-01 | 2022-02-16 |
| SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial Questionnaire Administration, Stereotactic Radiosurgery, Magnetic Resonance Imaging - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 2 | Recruiting | Mayo Clinic | 90 | 2022-03-14 | 2026-10-01 |
| Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases Stereotactic Radiation, AGuIX gadolinium-based nanoparticles, Placebo - Brain Cancer, Brain Metastases | Phase 2 | Recruiting | Brigham and Women's Hospital | 134 | 2021-09-15 | 2026-09-09 |
| Preoperative Radiotherapy in Patients at High Risk of Postoperative Pancreatic Fistula After Pancreatoduodenectomy Stereotactic radiotherapy - Neuroendocrine Carcinoma of Pancreas, Duodenum Carcinoma | Phase 1 / Phase 2 | Unknown | Erasmus Medical Center | 33 | 2020-12-01 | 2022-12-07 |
| Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis Questionnaire Administration, Stereotactic Radiosurgery - Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 55 | 2020-08-28 | 2026-09-14 |
| A Prospective Randomized Trial of High Dose Versus Standard Dose Stereotactic Radiotherapy for Pain Control in Patients With Bone Metastases Stereotactic Radiotherapy - Bone Metastases, Radiotherapy Side Effect | Phase 2 | Unknown | National Taiwan University Hospital | 302 | 2019-08-30 | 2019-08-21 |
| Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) Ipilimumab, Nivolumab, Stereotactic Radiotherapy - Melanoma Stage Iv | Phase 2 | Recruiting | Melanoma Institute Australia | 218 | 2019-08-14 | 2026-10-08 |
| Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma Biospecimen Collection, Echocardiography Test, Ipilimumab - Grade 2 Meningioma, Grade 3 Meningioma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 38 | 2019-06-17 | 2026-07-31 |
| Study of Osimertinib + SRS vs Osimertinib Alone for Brain Metastases in EGFR Positive Patients With NSCLC Osimertinib, Stereotactic radiotherapy - Lung Cancer Non-small Cell Stage IV, Brain Metastases | Phase 2 | Active not recruiting | British Columbia Cancer Agency | 40 | 2019-03-19 | 2024-10-31 |
| STR + Anti PD-1 Therapy in Patients with Locally Advanced Unresectable Pancreatic Adenocarcinoma Nivolumab, Stereotactic radiotherapy - Locally Advanced Unresectable Pancreatic Adenocarcinoma | Phase 1 / Phase 2 | Completed | University Hospital Hradec Kralove | 15 | 2018-12-03 | 2024-09-23 |
| SBRT + PD-1/PDL-1 Inhibiting Therapy for Advanced Solid Tumors After Dz Control on PD-1/PDL-1 Tx Stereotactic radiotherapy, Biological: humanized anti-PD-1 monoclonal antibody, Biological: humanized anti-PD-L1 monoclonal antibody - Solid Tumor | Phase 2 | Completed | Virginia Commonwealth University | 5 | 2017-10-10 | 2022-01-10 |
| Neoadjuvant Chemotherapy and Stereotactic Radiosurgery to Pancreatectomy for Patients With Borderline Resectable Pancreatic Cancer Chemotherapy, Stereotactic radiotherapy, Surgery - Pancreatic Neoplasms | Phase 2 | Withdrawn | Centre Francois Baclesse, Luxembourg | 2017-04-20 | 2022-06-23 | |
| Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer Cognitive Assessment, Ipilimumab, Laboratory Biomarker Analysis - Metastatic Malignant Neoplasm in the Brain, Stage IV Non-Small Cell Lung Cancer AJCC v7 | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 80 | 2016-12-16 | 2026-05-20 |
| Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration - Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 60 | 2016-08-29 | 2026-10-07 |
Showing 20 of 31. Sign in to see all of them.
Brain Neoplasms (12) · Carcinoma, Non-Small-Cell Lung (6) · Melanoma (6) · Breast Neoplasms (4) · Pancreatic Neoplasms (3) · Carcinoma, Hepatocellular (2) · Carcinoma, Renal Cell (2) · Gastrointestinal Neoplasms (2) · Lung Neoplasms (2) · Neoplasm Metastasis (2) · Prostatic Neoplasms (2) · Small Cell Lung Carcinoma (2) · Breast Neoplasms, Male (1) · Clear-cell metastatic renal cell carcinoma (1) · Colonic Neoplasms (1)
M.D. Anderson Cancer Center (5) · National Cancer Institute (NCI) (3) · Mayo Clinic (2) · Sunnybrook Health Sciences Centre (2) · AHS Cancer Control Alberta (1) · Brigham and Women's Hospital (1) · British Columbia Cancer Agency (1) · Case Comprehensive Cancer Center (1) · Centre Francois Baclesse, Luxembourg (1) · Erasmus Medical Center (1) · First Affiliated Hospital of Guangxi Medical University (1) · Fudan University (1) · Groupe Oncologie Radiotherapie Tete et Cou (1) · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS (1) · Melanoma Institute Australia (1)
United States (14) · Canada (6) · China (3) · South Korea (2) · Australia (1) · Czechia (1) · France (1) · Italy (1) · Luxembourg (1) · Netherlands (1) · Norway (1) · Saudi Arabia (1)
Jing Li (4) · Alfredo Urdaneta, M.D. (1) · Amol J Ghia (1) · Anwen Liu (1) · Ayal Aizer, MD, MHS (1) · Bently Doonan, MD, MS (1) · Bing Lu (1) · Cheryl Ho, MD, FRCPC (1) · Chuangzhou Rao (1) · Dejun XIng (1) · Fang Liu (1) · Federica Matteucci (1) · Georg A. Bjarnason, MD, FRCPC (1) · Georgina V Long, MBBS PhD (1) · Guang Han (1)
PMID 33450821, PMID 35602670, PMID 37506981, PMID 38796495, PMID 39317507, PMID 39441483, PMID 41293180, PMID 41534788, PMID 42682622
P30CA016672 (2), U10CA180868 (2), N01CM00039 (1), P30CA015704 (1), P30CA016059 (1), U01CA062461 (1), U01CA069852 (1), U01CA076576 (1), U10CA021661 (1), UM1CA186689 (1), UM1CA186704 (1)