12 completed, 5 unknown, 3 recruiting, 1 terminated. 6 Phase 2, 5 Phase 3, 4 Not applicable, 3 Early Phase 1, 3 Phase 1.
Follow Sonazoid: new trials by email Literature Review of Sonazoid trials Research Report on Sonazoid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Contrast-enhanced Ultrasound for Sentinel Node Detection Sonazoid - Melanoma, Breast Cancer | Phase 2 / Phase 3 | Recruiting | The Netherlands Cancer Institute | 91 | 2025-09-18 | 2025-12-30 |
| Y-90 Treatment Response Using Transarterial Radioembolization Lumason, Sonazoid - HCC, Hepatocellular Carcinoma | Phase 2 | Recruiting | Thomas Jefferson University | 30 | 2025-09-11 | 2026-06-10 |
| Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal SHAPE measurement (Sonazoid ultrasoud contrast agent), SHAPE measurement (Definity ultrasoud contrast agent) - Liver Diseases, Portal Hypertension | Phase 3 | Recruiting | Thomas Jefferson University | 660 | 2022-11-28 | 2026-10-02 |
| Gynecological Sentinel Lymph Nodes CEUS Perflubutane Microbubble, Contrast-Enhanced Ultrasound - Cervical Carcinoma, Malignant Female Reproductive System Neoplasm | Early Phase 1 | Completed | Thomas Jefferson University | 9 | 2022-04-28 | 2025-08-22 |
| Role of Perfluorobutane in Lesion Detection, Targeting and Response Assessment for Ablation of HCC Perfluorobutane - Hepatocellular Carcinoma, Microwave Ablation | Not applicable | Completed | Institute of Liver and Biliary Sciences, India | 21 | 2021-10-01 | 2021-12-21 |
| A Prospective Multi-center Study on Using Sonazoid Diagnose Early Stage Endometrial Cancer Perflubutane Microspheres for Injection - Endometrial Carcinoma Stage I | Unknown | Chinese PLA General Hospital | 277 | 2020-10-01 | 2021-07-14 | |
| Added Value in Combined Use of Fusion Imaging and Contrast-enhanced Ultrasonography SONAZOID - Contrast Media, Liver, Biopsy, Fusion | Not applicable | Unknown | Seoul National University Hospital | 44 | 2020-06-02 | 2021-04-08 |
| Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC Sonovue and Sonazoid, Sonazoid and Sonovue - Hepatocellular Carcinoma, Cirrhosis | Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2019-06-30 | 2019-09-19 |
| Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA), Contrast-Enhanced Ultrasound, Fine-Needle Aspiration - Esophagus | Early Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 35 | 2018-09-06 | 2025-05-18 |
| Ischemic Memory Imaging With Myocardial Contrast Echocardiography Sonazoid - Myocardial Ischemia | Early Phase 1 | Unknown | Oregon Health and Science University | 40 | 2018-07-07 | 2018-08-23 |
| Contrast Enhanced Ultrasonography to Detect Human Renal Transplant Rejection Sonazoid, contrast enhanced ultrasonography - Renal Transplant Rejection | Phase 2 | Completed | Brigham and Women's Hospital | 8 | 2018-05-30 | 2023-03-06 |
| Noninvasive Real-time Intracardiac Pressure Measurements Using Subharmonic Ultrasound Sonazoid - Cardiac Catheterization, Blood Pressure | Phase 2 | Completed | Thomas Jefferson University | 80 | 2017-12-04 | 2024-05-29 |
| Evaluation of Suspected Liver Pathology in Patients With Contraindications for Contrast Enhanced CT and/or MRI Sonazoid - Liver Metastasis, Liver Mass | Phase 3 | Withdrawn | Northeastern Ohio Radiology Research and Education Fund | 2017-10-01 | 2017-09-13 | |
| Sonazoid-Enhanced Ultrasound in Detecting Sentinel Lymph Node in Patients With Cutaneous Melanoma Sentinel Lymph Node Biopsy, Ultrasonography, Sonazoid - Cutaneous Melanoma, Melanoma | Phase 1 | Terminated | University of Southern California | 5 | 2017-04-26 | 2020-03-30 |
| Contrast Ultrasound Perfusion Imaging in PAD With Sonazoid Contrast ultrasound of leg muscle with Sonazoid (Contrast ultrasound microvascular perfusion imaging) - Peripheral Artery Disease | Phase 2 | Unknown | Oregon Health and Science University | 55 | 2016-08-01 | 2017-06-19 |
| Superb Microvascular Imaging in Focal Nodular Hyperplasia Sonazoid, Superb-Microvascular imaging - Focal Nodular Hyperplasia | Not applicable | Completed | Samsung Medical Center | 62 | 2016-05-01 | 2019-12-17 |
| Contrast Ultrasound Detection of Sentinel Lymph Nodes Sonazoid; Perflubutane for Injection - Breast Cancer | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 98 | 2016-01-01 | 2023-01-23 |
| Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension SHAPE measurement (Sonazoid ultrasoud contrast agent) - Liver Diseases, Portal Hypertension | Phase 4 | Completed | Thomas Jefferson University | 178 | 2015-04-06 | 2021-08-13 |
| A Study to Evaluate Pharmacokinetics of Sonazoid™ Following Intravenous Bolus Injection in Healthy Volunteers Sonazoid™ - Healthy | Phase 1 | Completed | GE Healthcare | 16 | 2014-10-20 | 2017-11-14 |
| An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging Sonazoid™, SonoVue® - Liver Lesions | Phase 3 | Completed | GE Healthcare | 424 | 2014-05-11 | 2018-10-31 |
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Carcinoma, Hepatocellular (3) · Breast Neoplasms (2) · Hypertension, Portal (2) · Liver Diseases (2) · Melanoma (2) · Carcinoma (1) · Diabetes Mellitus (1) · Endometrial Neoplasms (1) · Fibrosis (1) · Focal Nodular Hyperplasia (1) · Glucose Intolerance (1) · Head and Neck Neoplasms (1) · Heart Failure (1) · Liver Neoplasms (1) · Myocardial Ischemia (1)
Thomas Jefferson University (5) · GE Healthcare (2) · Oregon Health and Science University (2) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · Brigham and Women's Hospital (1) · Chinese PLA General Hospital (1) · Glostrup University Hospital, Copenhagen (1) · Institute of Liver and Biliary Sciences, India (1) · Northeastern Ohio Radiology Research and Education Fund (1) · Samsung Medical Center (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Seoul National University Hospital (1) · The Netherlands Cancer Institute (1) · University of Milan (1) · University of Southern California (1)
United States (11) · China (4) · South Korea (3) · Denmark (1) · India (1) · Italy (1) · Netherlands (1) · Switzerland (1) · Taiwan (1)
Flemming Forsberg, PhD (3) · Francois Tranquart, MD, PhD (2) · Ji-Bin Liu, MD (2) · Amar Mukund, MBBS, MD (1) · Guido Torzilli, MD, PhD (1) · Jaydev K Dave (1) · Jeong Min Lee, MD, PhD (1) · John Eisenbrey, PhD (1) · Kevin King, MD (1) · Michael Larsen, MD, DMsc (1) · Ping Liang (1) · Quirijn Tummers (1) · Reza Abdi, MD (1) · Woo Kyoung Woo, M.D. (1)
PMID 31335773, PMID 33201789, PMID 34763776, PMID 35079778, PMID 35842563, PMID 38358329
R01DK098526 (2), P30CA014089 (1), R01CA172336 (1), R21CA218946 (1), R21CA249870 (1), R21CA303648 (1), R21HL130899 (1)