15 completed, 7 terminated, 4 unknown, 2 active not recruiting. 10 Phase 1, 6 Phase 2, 5 Not applicable, 3 Early Phase 1, 3 Phase 4.
Follow Sodium Nitroprusside: new trials by email Literature Review of Sodium Nitroprusside trials Research Report on Sodium Nitroprusside
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of Endothelial Function in SCI CVD Risk Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid), venous occlusion plethysmography, Acetylcholine - Spinal Cord Injuries, Cardiovascular Diseases | Recruiting | Craig Hospital | 60 | 2024-09-01 | 2024-08-20 | |
| Estrogen and Microvascular Function Nω-nitro-L-arginine methyl ester (L-NAME), Acetylcholine, Sodium Nitroprusside - Estrogen, Cardiovascular Diseases | Active not recruiting | Medical College of Wisconsin | 45 | 2023-10-12 | 2026-07-29 | |
| Sex Differences in Sympathetic Vascular Reactivity at High Altitude Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 17 | 2022-07-28 | 2024-09-19 |
| Effect of C21 on Forearm Blood Flow C21, Sodium Nitroprusside - Study Vasodilatory Effects of C21 | Phase 1 | Completed | Vicore Pharma AB | 5 | 2022-04-28 | 2025-04-23 |
| Sodium Nitroprusside in Early Course Schizophrenia Sodium Nitroprusside, 5% Dextrose solution - Schizophrenia, Schizoaffective Disorder | Phase 2 | Terminated | Beth Israel Deaconess Medical Center | 1 | 2022-03-14 | 2025-12-30 |
| Hot Flashes and Neurovascular Function in Women Sympathoexcitatory stressors, Sodium Nitroprusside, Acetylcholine - Hot Flashes, Menopause | Not applicable | Recruiting | Mayo Clinic | 120 | 2022-02-24 | 2026-06-12 |
| The Impact of Carbon Monoxide and Altitude on Vascular Function Carbon monoxide rebreathe, Sodium Nitroprusside, Phenylephrine Hydrochloride - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 19 | 2021-06-10 | 2022-05-25 |
| Hemodynamic Optimization of Cerebral Perfusion After Endovascular Therapy in Patients With Acute Ischemic Stroke Adjusted medication - Acute Ischemic Stroke | Phase 4 | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 814 | 2021-06-01 | 2023-03-16 |
| Targeting ER Stress in Vascular Dysfunction Acetylcholine, Sodium Nitroprusside, Ascorbic Acid - Vasodilation, Arterial Stiffness | Early Phase 1 | Terminated | Colorado State University | 17 | 2019-06-01 | 2025-04-08 |
| HeartPhone Cancer Survivors Trial 2019 HeartPhone app, Acetylcholine, Sodium Nitroprusside - Breast Cancer, Leukemia | Phase 1 / Phase 2 | Terminated | Penn State University | 2 | 2019-04-23 | 2026-02-27 |
| Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training Handgrip Exercise Training, Acetylcholine, Adenosine Triphosphate - Vasoconstriction, Vasodilation | Early Phase 1 | Withdrawn | Colorado State University | 2019-04-16 | 2021-08-02 | |
| Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults Adenosine Triphosphate, Acetylcholine, Sodium Nitroprusside - Receptor Blockade | Early Phase 1 | Completed | Colorado State University | 9 | 2019-02-07 | 2021-07-27 |
| Anemia Study in Chronic Kidney Disease (CKD) : Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat -Forearm Blood Flow (ASCEND-FBF) Daprodustat, Darbepoetin alfa, Acetylcholine - Anaemia | Phase 2 | Terminated | GlaxoSmithKline | 6 | 2019-01-10 | 2024-03-27 |
| The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction BQ-788, BQ-123, L-Arginine - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 1 | Completed | The University of Texas at Arlington | 19 | 2018-10-01 | 2024-06-11 |
| Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Sodium nitroprusside, Dobutamine, Furosemide - Acute Heart Failure | Phase 4 | Withdrawn | Montefiore Medical Center | 2018-05-01 | 2018-10-31 | |
| The Effect of Antioxidants on Skin Blood Flow-BH4 Control: Lacated Ringers, Apocynin, Allopurinol - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 1 | Completed | The University of Texas at Arlington | 16 | 2018-01-08 | 2018-09-26 |
| Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity Phentolamine, Saline, Sodium Nitroprusside - Insulin Resistance, Healthy | Phase 1 | Active not recruiting | Vanderbilt University Medical Center | 36 | 2017-10-24 | 2026-03-02 |
| A Proof of Concept Study of Intravenous Sodium Nitroprusside in Adults With Symptomatic Schizophrenia sodium nitroprusside, Placebo - Schizophrenia | Phase 2 | Completed | Massachusetts General Hospital | 60 | 2015-05-01 | 2018-10-02 |
| Safety Study of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury Sodium Nitroprusside - Acute Lung Injury, Acute Respiratory Distress Syndrome | Phase 1 | Unknown | Mount Sinai Hospital, Canada | 30 | 2012-05-01 | 2012-06-14 |
| Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation Apelin, Acetylcholine, Sodium nitroprusside - Heart Disease, Heart Failure | Not applicable | Completed | University of Edinburgh | 12 | 2010-04-01 | 2010-08-10 |
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Aneurysm (5) · Cardiovascular Diseases (4) · Motor Activity (3) · Schizophrenia (3) · Heart Failure (2) · Hypertension (2) · Obesity (2) · Sarcopenia (2) · Acute Lung Injury (1) · Anemia (1) · Breast Neoplasms (1) · Cardiomyopathies (1) · Diabetes Mellitus (1) · Heart Diseases (1) · Hot Flashes (1)
Colorado State University (3) · The University of Texas Medical Branch, Galveston (3) · The Medicines Company (2) · The University of Texas at Arlington (2) · University Hospital, Angers (2) · University of Alberta (2) · Beth Israel Deaconess Medical Center (1) · Craig Hospital (1) · Emory University (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · GlaxoSmithKline (1) · Kavaklıdere Umut Hospital (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Medical College of Wisconsin (1)
United States (20) · Canada (3) · France (3) · United Kingdom (2) · Brazil (1) · Germany (1) · Spain (1) · Sweden (1) · Turkey (Türkiye) (1)
Frank Dinenno, PhD (3) · Sean van Diepen, MD, MSc (2) · Anand Chockalingam, MD (1) · Andrew Park, MD (1) · Arshed A Quyyumi, MD (1) · Blake Rasmussen, PhD (1) · Craig D Steinback, PhD (1) · Craig Steinback, PhD (1) · Elena Volpi, MD, PhD (1) · Italo Biaggioni, M.D. (1) · Jaime EC Hallak, Doctor (1) · Jean Louis Saumet, MD PhD (1) · Malcolm Lloyd, MD (1)
PMID 16030064, PMID 16614412, PMID 16896165, PMID 17351147, PMID 18323467, PMID 18342407, PMID 18713956, PMID 18787087, PMID 20876843, PMID 22338078, PMID 11927685, PMID 12122152, PMID 12237259, PMID 12793996, PMID 15153776, PMID 15498811, PMID 15563538, PMID 15798081, PMID 16365098, PMID 16464955, PMID 16705054, PMID 16868746, PMID 16873412, PMID 17478528, PMID 17569770, PMID 17885021, PMID 18056791, PMID 18090658, PMID 18236467, PMID 18317375, PMID 18347658, PMID 18403916, PMID 18535123, PMID 18806012, PMID 18827171, PMID 18845784, PMID 19057193, PMID 19150856, PMID 19188252, PMID 19588121, PMID 19828686, PMID 20070283, PMID 20150565, PMID 20304764, PMID 20484484, PMID 20519362, PMID 20724580, PMID 20844186, PMID 21076294, PMID 21430254
2017 (1), K01HL148144 (1), R01AG018311 (1), R01AG021539 (1), R01AR049877 (1), R01HL079115 (1)