7 completed, 3 terminated, 2 unknown, 2 withdrawn. 14 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 14 | Completed 7, Terminated 3, Unknown 2, Withdrawn 2 |
| Phase 2 | 4 | Completed 2, Terminated 2 |
Follow Sodium Nitrite: new trials by email Literature Review of Sodium Nitrite trials Research Report on Sodium Nitrite
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Sustained-release Oral Sodium Nitrite on Postoperative Pain and Recovery Following Total Knee Arthroplasty JAN101 SR, Placebo - Pain | Phase 1 | Withdrawn | University of Alabama at Birmingham | 2026-06-01 | 2025-06-24 | |
| Nitrite Infusion in Children With Malaria Sodium Nitrite - Falciparum Malaria | Phase 1 | Withdrawn | Duke University | 2021-06-01 | 2021-03-16 | |
| The Nitrite and Coronary Flow Study Sodium Nitrite - Cardiovascular Diseases, Vasodilation | Phase 1 / Phase 2 | Completed | University of East Anglia | 14 | 2018-07-01 | 2020-04-21 |
| The Haem and Nitrite Study - The Effects of Haemoglobin NO-blockade on Nitrite-induced Forearm Vessel Dilatation Sodium Nitrite - Healthy Volunteers | Phase 1 | Unknown | University of East Anglia | 41 | 2016-12-01 | 2017-03-20 |
| Phase 1 Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest Sodium Nitrite - Out-Of-Hospital Cardiac Arrest | Phase 1 | Completed | University of Washington | 120 | 2016-12-01 | 2018-05-07 |
| Inhaled Sodium Nitrite as an Antimicrobial for Cystic Fibrosis sodium nitrite - Cystic Fibrosis | Phase 1 / Phase 2 | Terminated | Schmidhofer, Mark, MD | 4 | 2016-02-01 | 2024-06-24 |
| The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Hypertensive Versus Healthy Subjects Sodium nitrite, Sodium chloride - Hypertension | Phase 1 | Unknown | Erling Bjerregaard Pedersen | 30 | 2015-05-01 | 2015-08-19 |
| The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Healthy Humans. A Dose-response Study Sodium nitrite, 40 micrograms/kg/hour, Sodium nitrite, 120 micrograms/kg/hour, Sodium nitrite, 240 micrograms/kg/hour - Healthy | Phase 1 | Completed | Erling Bjerregaard Pedersen | 12 | 2013-09-01 | 2014-10-09 |
| Sodium Nitrite to Treat Arterial Aging Placebo, Sodium Nitrite - Vascular Aging | Phase 1 / Phase 2 | Completed | University of Colorado, Boulder | 33 | 2011-10-01 | 2015-07-15 |
| Safety and Efficacy of Sodium Nitrite in Sickle Cell Disease sodium nitrite injection, usp - Sickle Cell Disease | Phase 1 / Phase 2 | Terminated | Children's Hospital Los Angeles | 5 | 2009-12-01 | 2017-10-17 |
| Effect of Nitrite on Exercise Physiology and Metabolism Sodium Nitrite - Healthy, Healthy Volunteer | Phase 1 | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 15 | 2005-03-08 | 2018-07-05 |
| Nitrite Infusion in Healthy Volunteers Sodium Nitrite, Sodium Nitrite Injection - Healthy | Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 12 | 2005-02-04 | 2017-07-02 |
| Nitrite Infusion Studies Oxypurinol, Sodium Nitrite - Healthy | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 36 | 2005-01-19 | 2017-07-02 |
| Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease L-NMMA, Sodium Nitrite - Sickle Cell Anemia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 18 | 2004-11-01 | 2019-11-05 |
Aneurysm (4) · Anemia, Sickle Cell (2) · Hypertension (2) · Hypoxia (2) · Cardiovascular Diseases (1) · Communicable Diseases (1) · Cystic Fibrosis (1) · Hypotension (1) · Malaria (1) · Malaria, Falciparum (1) · Methemoglobinemia (1) · Out-of-Hospital Cardiac Arrest (1) · Pain (1) · Vascular Diseases (1) · Vaso-Occlusive Crises (1)
National Heart, Lung, and Blood Institute (NHLBI) (3) · Erling Bjerregaard Pedersen (2) · University of East Anglia (2) · Children's Hospital Los Angeles (1) · Duke University (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Schmidhofer, Mark, MD (1) · University of Alabama at Birmingham (1) · University of Colorado, Boulder (1) · University of Washington (1)
United States (8) · Denmark (2) · United Kingdom (2) · Tanzania (1)
Allison E DeVan, Ph.D. (1) · Douglas R Seals, Ph.D. (1) · Erling B Pedersen, MD, DMSc (1) · Francis Kim, MD (1) · Gregory J Kato, M.D. (1) · Jennifer DeBerry, PhD (1) · Jesper N Bech, MD, PhD (1) · John F Tisdale, M.D. (1) · Joseph Pilewski, MD (1) · Michael P Frenneaux, FRCP (UK) (1) · Michael P Frenneaux, FRCP, FESC (1) · Thomas Coates, MD (1)
PMID 21249218, PMID 29065098, PMID 30205886
R01HL130763 (1)