8 recruiting, 7 completed, 5 not yet recruiting, 3 unknown. 24 Not applicable, 3 Phase 2, 1 Phase 1.
Follow this drug Literature Review of Sham taVNS trials Research Report on Sham taVNS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Probing Gut-Brain Communication in Parkinson's Disease taVNS, Sham taVNS - Parkinson Disease (PD) | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 45 | 2027-01-01 | 2026-10-08 |
| Transcutaneous Auricular Vagus Nerve Stimulation-Enriched Rehabilitation in Individuals With Lipedema Active taVNS, Sham taVNS, Aerobic Exercise - Lipedema | Not applicable | Recruiting | Istanbul University - Cerrahpasa | 30 | 2026-09-18 | 2026-10-05 |
| taVNS for Letter Learning in Dyslexia active taVNS, sham taVNS - Dyslexia | Not applicable | Suspended | University of Florida | 100 | 2026-09-01 | 2026-05-28 |
| How Does Vagus Nerve Stimulation Affect Blood Glucose, Food, and Movement Cravings? Active taVNS, Sham taVNS - Vagus Nerve Stimulation | Not applicable | Withdrawn | University of Minnesota | 2026-09-01 | 2026-07-20 | |
| Effect of Recording Duration on Heart Rate Variability During taVNS Transcutaneous Auricular Vagus Nerve Stimulation, Sham Stimulation - Healthy Volunteers | Not applicable | Not yet recruiting | Sinop University | 40 | 2026-05-01 | 2026-04-16 |
| Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation in Healthy Individuals Sham taVNS, taVNS 10 Hz, taVNS 25 Hz - Healthy Volunteers | Not applicable | Not yet recruiting | Sinop University | 36 | 2026-05-01 | 2026-04-16 |
| Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Breast Cancer Surgery Patients Active taVNS, Sham taVNS - Depression, Postoperative | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 232 | 2026-02-28 | 2026-03-09 |
| taVNS for Breast Cancer Pain and Symptom Management Active taVNS, Sham taVNS - Breast Cancer Survivors | Not applicable | Recruiting | Florida State University | 40 | 2026-02-24 | 2026-03-30 |
| taVNS on Functional Mobility in People With DP Active taVNS, Sham taVNS - PARKINSON DISEASE (Disorder) | Phase 2 | Not yet recruiting | Universidade Federal de Pernambuco | 30 | 2026-02-15 | 2026-01-26 |
| Association of VAgus Nerve Stimulation and Treadmill Training for GAit Rehabilitation in DE Novo Parkinson's Disease Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS), Conventional Physical Therapy (cPT) - Idiopathic Parkinson's Disease (PD) | Not applicable | Recruiting | Fondazione Policlinico Universitario Campus Bio-Medico | 60 | 2026-02-14 | 2026-07-16 |
| taVNS for Speech and Language Recovery in Aphasia taVNS, sham taVNS - Aphasia, Apraxia of Speech | Not applicable | Enrolling by invitation | University of Florida | 12 | 2026-01-01 | 2026-05-04 |
| Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD) Active taVNS, Sham taVNS - Chronic Kidney Diseases | Not applicable | Recruiting | NYU Langone Health | 30 | 2025-10-15 | 2025-12-31 |
| Efficacy of Trans-auricular Vagus Nerve Stimulation on Upper Extremity Motor Recovery in Stroke Survivors Active taVNS, Sham taVNS - Stroke | Not applicable | Recruiting | Universidade Federal de Pernambuco | 30 | 2025-08-01 | 2026-05-04 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms Active taVNS, Sham taVNS - Persistent Post-concussive Symptoms | Not applicable | Recruiting | University of Liege | 48 | 2025-05-28 | 2025-06-12 |
| Investigation to Understand and Optimize Psilocybin Psilocybin, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham taVNS - Depression | Phase 2 | Recruiting | Charles Raison | 141 | 2025-05-13 | 2026-08-10 |
| EFFECT OF TRANSCUTANEOUS ELECTRONEURO-STIMULATION OF THE VAGUS NERVE ON JOINT PAIN SEQUELAE OF CHIKUNGUNYA FEVER IN THE LOWER LIMBS Transcutaneous vagus nerve electrical stimulation, Transcutaneous eletrical nerve stimuation, Transcutaneous electrical nerve stimulation - Chronic Pain Management, Chronic Pain and Comorbid Emotional Problems | Not applicable | Active not recruiting | Universidade Federal de Pernambuco | 51 | 2025-02-04 | 2026-04-13 |
| The ENHANCE Study: taVNS and Psilocybin Psilocybin, Transcutaneous auricular Vagus Nerve Stimulation (taVNS), Psychosocial Support Alone - Healthy, Psychedelic Experiences | Phase 1 | Recruiting | University of Wisconsin, Madison | 115 | 2025-01-27 | 2026-10-20 |
| taVNS Reduces Postoperative Pain and Complications in Patients With Gastric and Intestinal Tumors taVNS, sham taVNS - taVNS, Gastrointestinal Tumor Surgery | Not applicable | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 80 | 2025-01-01 | 2025-08-27 |
| taVNS Paired With Motor Training for Upper-extremity Rehabilitation in Stroke Patients paired taVNS, Unpaired taVNS, Sham taVNS - Upper Extremity Dysfunction, Stroke | Not applicable | Unknown | Qiuyou Xie | 150 | 2023-08-01 | 2024-01-12 |
| Vagal Nerve Stimulation for Interoception Modulation taVNS, Sham taVNS - Healthy Adult | Not applicable | Completed | Massachusetts General Hospital | 25 | 2023-07-11 | 2026-07-06 |
Showing 20 of 28. Sign in to see all of them.
Depression (3) · Parkinson Disease (3) · Stroke (3) · Anxiety Disorders (2) · Inflammation (2) · Pain (2) · Aphasia (1) · Apraxias (1) · Arthritis, Juvenile (1) · Brain Injuries, Traumatic (1) · Central Nervous System Diseases (1) · Chronic Pain (1) · Consciousness Disorders (1) · Diabetes Mellitus, Type 2 (1) · Dyslexia (1)
Universidade Federal de Pernambuco (3) · Burrell College of Health Sciences (2) · Medical University of South Carolina (2) · Sinop University (2) · University of Florida (2) · University of Liege (2) · Charles Raison (1) · Chinese PLA General Hospital (1) · Florida State University (1) · Fondazione Policlinico Universitario Campus Bio-Medico (1) · Istanbul Gelisim University (1) · Istanbul University - Cerrahpasa (1) · Massachusetts General Hospital (1) · NYU Langone Health (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1)
United States (13) · Turkey (Türkiye) (4) · Brazil (3) · China (3) · Belgium (2) · Italy (1)
Charles Raison, MD (2) · Harald M Stauss, MD, PhD (2) · Aurore Thibaut, PT, PhD (1) · Aurore Thibaut, PhD (1) · Beth Gottlieb, MD (1) · Betty Diamond, MD (1) · Christopher W Austelle, MD (1) · Cynthia Aranow, MD (1) · Marc MP Possover, MD, PhD (1) · Mark Hartman, PhD (1) · Massimo Marano, MD, PhD (1) · Nicolas Lejeune, MD, PhD (1) · Qandeel Soomro, MD (1)
K01AT012208 (1), K23DK139462 (1), R25DA020537 (1), R41HD104409 (1), U01DK140933 (1)