115 completed, 63 unknown, 60 recruiting, 31 not yet recruiting. 252 Not applicable, 25 Phase 2, 10 Phase 1, 8 Phase 3, 4 Phase 4.
Follow Sham Stimulation: new trials by email Literature Review of Sham Stimulation trials Research Report on Sham Stimulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accelerated and Extended-iTBS Targeting Inhibitory Control in Veterans With ADHD Intermittent Theta-Burst Stimulation, Sham Stimulation - Attention Deficit Disorder With Hyperactivity | Not applicable | Not yet recruiting | VA Office of Research and Development | 35 | 2026-12-01 | 2026-10-02 |
| Gamma Light and Sound Stimulation in Schizophrenia GENUS, Sham Stimulation - Schizophrenia Spectrum Disorders | Not applicable | Not yet recruiting | Massachusetts Institute of Technology | 20 | 2026-12-01 | 2026-10-07 |
| Feasibility of Noninvasive Trigeminal Nerve Stimulation During Exercise Active Stimulation, Sham Stimulation, Fan therapy - COPD | Not applicable | Not yet recruiting | Johns Hopkins University | 40 | 2026-11-01 | 2026-10-14 |
| the Effect and Mechanism of Percutaneous Auricular Electrical Stimulation in Preventing Central Sensitization Pain in Patients With Rheumatoid Arthritis taVNS, Sham Stimulation - Rheumatoid Arthritis (RA), Transcutaneous Vagus Nerve Stimulation | Not applicable | Not yet recruiting | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 124 | 2026-10-01 | 2026-10-15 |
| Lily's Grace Temporal Interference TES-TI, Sham Stimulation, Structural and Functional MRI - Epilepsy | Not applicable | Not yet recruiting | University of Wisconsin, Madison | 24 | 2026-10-01 | 2026-09-29 |
| Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation Protocol 1: Combination of activity-based therapy and sham spinal cord stimulation, Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation - Spinal Cord Injury Cervical, Spinal Cord Injury, Acute | Not applicable | Not yet recruiting | Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal | 40 | 2026-09-01 | 2026-07-28 |
| Stimulation Evaluation for Neuromodulation Sensory Effects Intersectional Short-Pulse (ISP) Stimulation, Sham Stimulation - Sham-controlled, Healthy Adult Participants | Not applicable | Not yet recruiting | Adraxe Corp. | 30 | 2026-09-01 | 2026-08-21 |
| Vibratory Stimulation for the Treatment of Chronic Pain Vibrotactile Stimulation, Sham Stimulation - Chronic Pain, Pelvic Pain | Not applicable | Suspended | Stanford University | 50 | 2026-09-01 | 2026-04-24 |
| Investigating Modulation of Neuropathic Pain by Transcranial Magnetic Stimulation: a Multimodal Imaging and Electrophysiological Approach repetitive TMS, sham stimulation - Patients With Neuropathic Pain Due to Peripheral Neuropathy | Not applicable | Not yet recruiting | National Taiwan University Hospital | 52 | 2026-09-01 | 2026-08-11 |
| The Safety and Effectiveness of dTMS for Reducing Antipsychotic-induced Weight Gain dTMS of accelerated intermittent theta burst stimulation, ACC-iTBS, Sham stimulation - Schizophrenia Spectrum, Schizophrenia | Not applicable | Not yet recruiting | Second Xiangya Hospital of Central South University | 60 | 2026-09-01 | 2026-09-04 |
| Effects of Transcutaneous Tibial and Auricular Vagus Nerve Stimulation in Females With Primary Dysmenorrhea Transcutaneous Tibial Nerve Stimulation (TTNS), Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), TTNS+TaVNS - Primary Dysmenorrhea (PD) | Not applicable | Not yet recruiting | Riphah International University | 66 | 2026-09-01 | 2026-09-22 |
| Home-Based Wearable rTMS Therapy for Moderate to Severe Depression rTMS-Tiny Treatment, Sham Stimulation - Major Depressive Disorder | Not applicable | Not yet recruiting | Shanghai Mental Health Center | 124 | 2026-08-20 | 2026-08-20 |
| Neuromodulation of Mood Switch Circuitry in Bipolar Disorder MagVenture MagPro TMS system, Sham Stimulation - Bipolar Disorder (BD), Bipolar 1 Depression | Phase 4 | Recruiting | Weill Medical College of Cornell University | 62 | 2026-08-03 | 2026-09-23 |
| Transcranial Ultrasound Stimulation for Tourette Syndrome Focused ultrasound stimulation, Sham stimulation - Tourette Syndrome | Phase 1 | Not yet recruiting | University of Calgary | 20 | 2026-08-01 | 2026-07-13 |
| Auditory Stimulation for Insomnia and Depression Alpha phase-locked auditory stimulation, Sham Stimulation - Depression - Major Depressive Disorder, Insomnia | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2026-08-01 | 2026-08-27 | |
| Effect of Different Currents for Transcranial Modulation of the Sensorimotor Corticospinal Pathway in Healthy Subjects Transcranial Alternating Current Stimulation, Transcranial Direct Current Stimulation, Transcranial Random Noise Stimulation (tRNS) - Health Adult Subjects | Not applicable | Enrolling by invitation | Hospital de Clinicas de Porto Alegre | 14 | 2026-07-15 | 2026-09-21 |
| tACS for Working Memory in Schizophrenia transcranial alternating current stimulation, sham stimulation - Schizophrenia, Working Memory | Not applicable | Recruiting | Central South University | 30 | 2026-07-06 | 2026-07-14 |
| The Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals With Tiletamine Use Disorder Transcutaneous Auricular Vagus Nerve Stimulation, Sham Stimulation - Tiletamine Use Disorder, Substance Use Disorder (SUD) | Not applicable | Not yet recruiting | Shanghai Mental Health Center | 30 | 2026-07-01 | 2026-07-08 |
| TIS for Improving Cognitive Impairment in Schizophrenia temporal interference stimulation, Sham stimulation - Schizophrenia Disorder, Cognitive Impairments | Not applicable | Recruiting | Central South University | 50 | 2026-06-24 | 2026-07-17 |
| Combined Regulatory Effects of 40 Hz eTNS and Multisensory Stimulation on Brain Networks 40 Hz External Trigeminal Nerve Stimulation, 40 Hz Auditory Stimulation, 40 Hz Visual Stimulation - Healthy Participants | Not applicable | Recruiting | Xidian University | 30 | 2026-06-16 | 2026-07-01 |
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Stroke (32) · Depression (16) · Depressive Disorder, Major (13) · Schizophrenia (13) · Cognitive Dysfunction (12) · Ischemic Stroke (10) · Paresis (9) · Parkinson Disease (9) · Spinal Cord Injuries (9) · Alzheimer Disease (8) · Alcoholism (6) · Aphasia (5) · Chronic Pain (5) · Sleep Initiation and Maintenance Disorders (5) · Stress Disorders, Post-Traumatic (5)
University of Castilla-La Mancha (9) · University of Sao Paulo General Hospital (7) · Central South University (6) · Charite University, Berlin, Germany (6) · VA Office of Research and Development (6) · Shanghai Mental Health Center (5) · Medical University of South Carolina (4) · Nu Eyne Co., Ltd. (4) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · University Hospital Muenster (4) · University of Florida (4) · University of Oklahoma (4) · Beijing Tiantan Hospital (3) · Daniel Keszthelyi (3) · National Taiwan University Hospital (3)
United States (77) · China (52) · Germany (20) · Brazil (15) · Switzerland (12) · South Korea (11) · Spain (11) · Canada (10) · France (8) · Netherlands (8) · Italy (7) · Denmark (6) · Taiwan (6) · Turkey (Türkiye) (6) · Belgium (3)
Daniel Keszthelyi, MD, PhD (3) · Yi Tang, M.D., Ph.D. (3) · Adam J Woods, PhD (2) · Amal Jubran, MD (2) · Andre R Brunoni, MD, PhD (2) · David Spiegel, MD (2) · Dong-Xin Wang, MD, PhD (2) · George F Wittenberg, MD, PhD (2) · Guy Boeckxstaens, M.D. (2) · Melanie Boly, MD, PhD (2) · Mirza Obaid Baig, MSPT (2) · Noah S. Philip, MD (2)
PMID 33175411, PMID 33406266, PMID 1088404, PMID 10990547, PMID 14551397, PMID 14991818, PMID 15664172, PMID 15936729, PMID 17565358, PMID 18259738, PMID 18815775, PMID 19233729, PMID 19506141, PMID 19531606, PMID 19678808, PMID 19954851, PMID 20040569, PMID 20439832, PMID 20489170, PMID 20636706, PMID 21041783, PMID 21233468, PMID 21454399, PMID 21636820, PMID 21842404, PMID 21848929, PMID 22116795, PMID 22473780, PMID 23649720, PMID 23769413, PMID 23943367, PMID 24157459, PMID 24777384, PMID 24798585, PMID 25576060, PMID 26049730, PMID 26077087, PMID 26455532, PMID 26481726, PMID 26850210, PMID 26900584, PMID 27355577, PMID 27381076, PMID 27435610, PMID 27653882, PMID 27929004, PMID 28017706, PMID 28512443, PMID 28575667, PMID 28629447
2019 (2), 2014 (1), 2023 (1), 4UH3DA048502 (1), 5KL2TR001429 (1), I01RX000180 (1), I01RX003418 (1), K01AG050707 (1), P2CHD086844 (1), P30GM122734 (1), R01HL128393 (1), R01MH069887 (1), R01MH138939 (1), R01NR016055 (1), R03HD114768 (1)