10 completed, 4 not yet recruiting, 3 recruiting, 2 unknown. 13 Phase 1, 11 Phase 2, 2 Not applicable, 2 Phase 3, 1 Early Phase 1.
Follow Secretome: new trials by email Literature Review of Secretome trials Research Report on Secretome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Efficacy of hUCMSC-Secretome Delivered Via Microneedling and Intradermal Microinjection as Adjuvant Therapy to NB-UVB in Nonsegmental Vitiligo: A Quasi-Experimental Study NB-UVB combined with microneedling and topical 10% secretome, receives NB-UVB combined with intradermal secretome injection, NB-UVB alone - Vitiligo | Phase 2 / Phase 3 | Not yet recruiting | Yohanes Firmansyah, dr, MH, MM | 150 | 2026-03-18 | 2026-04-03 |
| Umbilical Cord Mesenchymal Stromal Cell Secretome for Moderate Rheumatoid Arthritis Umbilical Cord-Derived Mesenchymal Stromal Cell (UC-MSC) Secretome, Placebo (Normal Saline) - Rheumatoid Arthritis | Phase 2 | Completed | Universitas Sriwijaya | 40 | 2026-02-04 | 2026-09-16 |
| Secretome vs. PRP Injections for Hair Density and Growth in Androgenetic Alopecia Patients Secretome, Platelet-Rich Plasma (PRP) Injections - Androgenetic Alopecia | Phase 1 / Phase 2 | Recruiting | PT. Prodia Stem Cell Indonesia | 40 | 2026-01-09 | 2026-02-24 |
| Effectiveness of Amniotic Membrane Combined With Secretome as an Adjunct to Carpal Tunnel Release Surgery: Evaluation Using the Boston Carpal Tunnel Questionnaire and Electromyography Secretome, amniotic membrane, Standard surgery - Carpal Tunnel Syndrome (CTS) | Early Phase 1 | Recruiting | PT. Prodia Stem Cell Indonesia | 30 | 2025-12-15 | 2026-07-23 |
| Comparison of Six-Month Functional Outcomes Following Anterior Cruciate Ligament (ACL) Reconstruction Using Peroneus Longus Tendon Grafts With Adjunctive Secretome Injection Versus Without Secretome Injection Secretome, Placebo - ACL Injury, ACL Tear | Not applicable | Completed | PT. Prodia Stem Cell Indonesia | 24 | 2025-11-14 | 2026-07-23 |
| The Relationship Between Microbioma Balance and Acne Vulgaris as a New Acne Treatment Standard therapy, HEXBIO, Secretome - Acne Vulgaris | Phase 2 | Not yet recruiting | Universitas Padjadjaran | 64 | 2025-05-01 | 2025-04-13 |
| Safety and Feasibility of Human Umbilical Cord Mesenchymal Stem Cell-Derived Secretome in the Treatment of Liver Cirrhosis: a Comprehensive Evaluation of Fibrosis Reduction, Immunomodulation, and Hepatic Regeneration: a Single Center, Randomized, Phase I Clinical Trial Secretome - Liver Cirrhosis | Phase 1 | Not yet recruiting | Baermed | 54 | 2024-12-01 | 2024-10-08 |
| Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Drug Resistant Epilepsy Single Center, Non-randomized, Phase I Clinical Trial Secretome - Epilepsy, Drugs Resistant Epilepsy | Phase 1 | Not yet recruiting | Baermed | 54 | 2024-12-01 | 2024-10-15 |
| Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Moderate Neurocognitive Impairment (Dementia) Secretome injection, Vitamin B12 Injection - Dementia, Moderate Dementia | Phase 1 | Unknown | Baermed | 54 | 2024-10-15 | 2024-10-09 |
| Proof of Concept Study to Isolate Cosmetic Improvement of Skin Using the Vitro Biopharma Secretome/Exosome Serum Secretome/Exosome Serum - Cosmetic Effect | Not applicable | Completed | Vitro Biopharma Inc. | 7 | 2024-04-17 | 2026-06-02 |
| Mesenchymal Stem Cells (MSCs) and Conditioned Medium Mesenchymal Stem Cells as Adjuvant Therapy for Sepsis Control (NaCl 0.9%), UC-MSC, UC-MSC and Secretome - Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Recruiting | PT. Prodia Stem Cell Indonesia | 15 | 2023-12-25 | 2026-02-27 |
| Effect of PMSCs and Their Secretome for the Treatment of GvHD Secretome (set of substances released from the cell to its surroundings) of mesenchymal stem cells retrieved from the placenta (containing 400 microgram protein/ milliliter), 4 cc distilled water dissolved in albumin 20% - GVHD | Phase 3 | Completed | Tabriz University of Medical Sciences | 60 | 2023-01-01 | 2024-06-21 |
| Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis Platelet-rich Plasma, Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome, Low Molecular Weight Hyaluronic Acid - Knee Osteoarthritis | Phase 1 / Phase 2 | Completed | Universitas Sriwijaya | 45 | 2022-10-02 | 2026-05-22 |
| Stem Cells and Secretomes for Infertility Therapy in Polycystic Ovary Syndrome (PCOS) Patients With Insulin Resistance. UC-MSCs, Secretomes, UC-MSCs and Secretomes - Polycystic Ovary Syndrome | Phase 1 / Phase 2 | Completed | PT. Prodia Stem Cell Indonesia | 44 | 2022-09-01 | 2026-02-25 |
| The Effects of Mesenchymal Stem Cell Secretome in Lupus Patients Secretome, Placebo - Lupus Erythematosus | Phase 1 / Phase 2 | Completed | Universitas Sebelas Maret | 15 | 2022-08-01 | 2023-06-27 |
| Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Acute Stroke Infarct Conditioned Medium, Umbilical Cord Mesenchymal Stem Cells, Neurologic and Neutrophic Drugs - Ischemic Stroke | Phase 1 / Phase 2 | Active not recruiting | PT. Prodia Stem Cell Indonesia | 15 | 2022-05-30 | 2026-02-25 |
| Skin Rejuvenation Using Stem Cell Secretome secretome - Skin Rejuvenation | Phase 1 | Completed | COR clinic of Regenerative Medicine | 49 | 2021-03-05 | 2024-02-06 |
| Implantation of Mesenchymal Stem Cell, Conditioned Medium, or Triamcinolone Acetonide for Keloid Umbilical Cord-Mesenchymal Stem Cells and Conditioned Medium, Conditioned Medium, Triamcinolone Acetonide - Keloid | Phase 1 / Phase 2 | Unknown | PT. Prodia Stem Cell Indonesia | 24 | 2020-09-01 | 2020-07-15 |
| Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium Therapy for Osteoartrithis Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome, Arthroscopy with Secretome + Mesenchymal Stem Cells + Secretome, Non Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome - Osteoarthritis, Knee | Phase 1 / Phase 2 | Completed | PT. Prodia Stem Cell Indonesia | 31 | 2020-08-03 | 2026-02-25 |
| Potential Injection of Human Umbilical Cord Secretome in the Case of Trophic Ulcers (Pre-post Intervention) Secretome - Trophic Ulcer, Leprosy | Phase 1 | Completed | Yohanes Firmansyah, dr, MH, MM | 27 | 2019-01-01 | 2026-04-02 |
Osteoarthritis, Knee (2) · Acne Vulgaris (1) · Alopecia (1) · Anterior Cruciate Ligament Injuries (1) · Arthritis, Rheumatoid (1) · Carpal Tunnel Syndrome (1) · Dementia (1) · Drug Resistant Epilepsy (1) · Epilepsy (1) · Graft vs Host Disease (1) · Ischemic Stroke (1) · Keloid (1) · Leprosy (1) · Liver Cirrhosis (1) · Osteoarthritis (1)
PT. Prodia Stem Cell Indonesia (8) · Baermed (3) · Universitas Sriwijaya (2) · Yohanes Firmansyah, dr, MH, MM (2) · COR clinic of Regenerative Medicine (1) · Tabriz University of Medical Sciences (1) · Universitas Padjadjaran (1) · Universitas Sebelas Maret (1) · Vitro Biopharma Inc. (1)
Indonesia (16) · Iran (1) · Lebanon (1) · United States (1)
Rima Haifa, B.Sc (2) · Babak Nejati, MD (1) · Graciela Pavon-Djavid, PhD (1) · Hossein Ghasemi Moghadam, MD (1) · Michael Jansen Politan (1) · Nada Alaaeddine, PhD (1) · Nurhasan Agung Prabowo, MD (1) · Radiyati U Partan, MD (1) · Radiyati Umi Partan, Professor, MD, PhD (1) · Rima Haifa (1) · Sepideh Zununi Vahed, PhD (1) · Sukmawati Tansil Tan (1) · Surya Darma, MD (1) · Yohanes Firmansyah (1)
PMID 16248209, PMID 21756569, PMID 22826694, PMID 22846185, PMID 25389921, PMID 25530971, PMID 25771459, PMID 25884704, PMID 28841158, PMID 31148869, PMID 31389998, PMID 34181079, PMID 34912736, PMID 42242743