10 completed, 10 unknown, 3 recruiting, 3 withdrawn. 11 Phase 4, 5 Phase 2, 3 Not applicable, 2 Phase 1, 2 Phase 3.
Follow Sacubitril-Valsartan: new trials by email Literature Review of Sacubitril-Valsartan trials Research Report on Sacubitril-Valsartan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| [11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan - Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild | Phase 1 | Not yet recruiting | Stony Brook University | 18 | 2026-10-01 | 2026-10-02 |
| Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction Sacubitril-valsartan, Valsartan - Heart Failure With Preserved Ejection Fraction, Myocardial Fibrosis | Phase 4 | Withdrawn | Brigham and Women's Hospital | 2026-08-27 | 2026-08-31 | |
| Sacubitril-valsartan in Patients With Heart Failure. Sacubitril-valsartan, standard treatment of heart failure - Heart Failure | Not applicable | Completed | Damanhour University | 60 | 2025-08-01 | 2026-04-21 |
| Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM) Sacubitril-valsartan, Placebo - Breast Cancer, Neoplasm, Breast | Phase 4 | Recruiting | Silesian Centre for Heart Diseases | 600 | 2024-04-17 | 2025-03-14 |
| Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation Sacubitril-valsartan, Standard of care - Heart Failure With Preserved Ejection Fraction, Functional Mitral Regurgitation | Phase 4 | Completed | Ziekenhuis Oost-Limburg | 84 | 2024-02-29 | 2026-06-08 |
| Initiation of ARNi and SGLT2i in Patients With HFrEF Sacubitril-valsartan, SGLT2 inhibitor - Heart Failure With Reduced Ejection Fraction | Phase 4 | Completed | Universidade do Porto | 62 | 2023-08-04 | 2025-11-19 |
| Sacubitril Valsartan in Preventing the Recurrence of Atrial Fibrillation After Ablation in Elderly Hypertensive Patients With Atrial Fibrillation Sacubitril-valsartan, Valsartan - Atrial Fibrillation Recurrent, Hypertension | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 320 | 2023-02-06 | 2026-02-10 |
| Pulmonary REsistance Modification Under Treatment With Sacubitril/valsartaN in paTients With Heart Failure With Reduced Ejection Fraction Sacubitril-valsartan, Enalapril, placebo - Heart Failure | Phase 4 | Unknown | Clinical Hospital Heliodor Swiecicki of the Medical University of Karol Marcinkowski in Poznań | 260 | 2022-12-13 | 2023-06-18 |
| Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation Sacubitril-valsartan, Placebo - Hemodialysis | Phase 2 | Completed | Brigham and Women's Hospital | 45 | 2022-10-11 | 2026-06-08 |
| Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan Sacubitril-valsartan, Valsartan, Carvedilol - Heart Failure, Heart Dysfunction | Phase 1 / Phase 2 | Recruiting | Virginia Commonwealth University | 70 | 2022-08-11 | 2026-07-08 |
| Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB Sacubitril-valsartan, Amlodipine-losartan - Aortic Valve Insufficiency | Phase 2 | Unknown | Samsung Medical Center | 100 | 2022-01-12 | 2022-01-28 |
| The Effects of Sacubitril-Valsartan vs Enalapril on Left Ventricular Remodeling in ST-elevation Myocardial Infarction Sacubitril-Valsartan, Enalapril, Valsartan - STEMI | Phase 3 | Unknown | West China Hospital | 376 | 2021-11-01 | 2021-09-29 |
| Sacubitril/Valsartan Versus Valsartan in Heart Failure With Improved Ejection Fraction Sacubitril-Valsartan, Valsartan - Heart Failure, Systolic | Unknown | Samsung Medical Center | 100 | 2021-03-16 | 2021-08-18 | |
| Sacubitril/Valsartan in Left Ventricular Assist Device Recipients Sacubitril-Valsartan, Standard of care - Heart Failure | Phase 4 | Unknown | University of Zagreb | 60 | 2021-02-05 | 2024-03-27 |
| Sacubitril/Valsartan in Resistant Hypertension Sacubitril-Valsartan - Resistant Hypertension, Blood Pressure | Phase 2 | Completed | Hospital Geral Roberto Santos | 80 | 2020-11-11 | 2025-02-24 |
| Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure Sacubitril-Valsartan - Heart Failure With Reduced Ejection Fraction | Completed | University of Leipzig | 117 | 2020-07-21 | 2026-04-08 | |
| Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy Dapagliflozin, Sacubitril-Valsartan, Beta blocker - Hypotension, Heart Failure | Phase 4 | Completed | Cheng-Hsin General Hospital | 78 | 2020-05-29 | 2021-08-02 |
| Study of Sacubitril/ValsarTan on MyocardIal OxygenatioN and Fibrosis in Heart Failure With Preserved Ejection Fraction Sacubitril-Valsartan - Heart Failure With Preserved Ejection Fraction | Phase 3 | Withdrawn | Flinders University | 2020-02-01 | 2021-08-30 | |
| The Bio-Clinical Effects of the (Sacubitril-Valsartan) Combination on Patients With Chronic Heart Failure Sacubitril-Valsartan, Valsartan - Heart Failure | Phase 4 | Completed | Amir Safwat | 60 | 2020-01-01 | 2022-06-24 |
| Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output Sacubitril-Valsartan, Standard Oral Vasodilators - Cardiogenic Shock | Phase 4 | Withdrawn | The Cleveland Clinic | 2019-11-25 | 2020-10-05 |
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Heart Failure (12) · Atrial Remodeling (2) · Cardiotoxicity (2) · Hypertension (2) · Ventricular Remodeling (2) · Aortic Valve Insufficiency (1) · Atrial Fibrillation (1) · Breast Diseases (1) · Breast Neoplasms (1) · Cognitive Dysfunction (1) · Dementia (1) · Encephalitis (1) · Heart Failure, Systolic (1) · Hypotension (1) · Motor Activity (1)
Brigham and Women's Hospital (2) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (2) · Samsung Medical Center (2) · The Cleveland Clinic (2) · Amir Safwat (1) · Centro Cardiologico Monzino (1) · Cheng-Hsin General Hospital (1) · Clinical Hospital Heliodor Swiecicki of the Medical University of Karol Marcinkowski in Poznań (1) · Damanhour University (1) · Flinders University (1) · Hospital Geral Roberto Santos (1) · Mark Ledwidge (1) · Shanghai Jiao Tong University School of Medicine (1) · Silesian Centre for Heart Diseases (1) · Stony Brook University (1)
United States (5) · Poland (3) · China (2) · Egypt (2) · South Korea (2) · Spain (2) · Belgium (1) · Brazil (1) · Croatia (1) · Czechia (1) · Germany (1) · Greece (1) · Ireland (1) · Italy (1) · Netherlands (1)
Carmine De Pasquale, Assoc Prof (1) · Daniel Lavall, MD (1) · David Kaye, Professor (1) · Eun Kyoung Kim, MD, PhD (1) · Finnian Mc Causland, MBBCh, MMSc (1) · Fiona Ryan, Co-Investigator, PhD (1) · Gonzalo Baron Esquivias (1) · Hung-Yu Chang, MD (1) · Ignatios Ikonomidis, Assoc. Prof (1) · Jerry D Estep, MD (1) · Maja Cikes, MD, PhD (1) · Majo Joseph, Doctor (1)
PMID 29754651, PMID 34668596, PMID 36884247, PMID 37449716, PMID 39983618, PMID 40818766, PMID 41390047, PMID 42104906, PMID 42349572
2015 (1), K23HL168163 (1), R01DK129749 (1), R21AG102953 (1)