17 unknown, 15 completed, 6 active not recruiting, 4 not yet recruiting. 37 Not applicable, 2 Phase 3, 2 Phase 4, 1 Phase 2.
Follow Root canal treatment: new trials by email Literature Review of Root canal treatment trials Research Report on Root canal treatment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Effect of Different Apical Motion Algorithms on Postoperative Pain After Root Canal Treatment Root Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation - Apical Periodontitis, Postoperative Pain After Endodontic Treatment | Not applicable | Not yet recruiting | Alanya Alaaddin Keykubat University | 120 | 2026-07-20 | 2026-07-20 |
| Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers root canal treatment - Root Canal Treatment, Irreversible Acute Pulpitis | Not applicable | Not yet recruiting | Cairo University | 30 | 2026-05-01 | 2026-05-08 |
| Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis Root canal treatment - Intracanal Medicaments, Inflammatory Cytokines | Not applicable | Active not recruiting | Mansoura University | 36 | 2026-03-01 | 2026-04-16 |
| The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion. root canal treatment - Necrotic Pulp With Symptomatic Apical Periodontitis | Not applicable | Active not recruiting | Future University in Egypt | 52 | 2026-01-03 | 2026-06-03 |
| Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis Total Pulpotomy, Radicular pulpotomy, Root canal treatment - Post-operative Pain, Pulpitis - Irreversible | Not applicable | Recruiting | Mustafa Kemal University | 99 | 2025-12-01 | 2026-06-05 |
| Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic Vital Pulp Therapy, Root Canal Treatment - Symptomatic Irreversible Pulpitis | Not applicable | Active not recruiting | Ain Shams University | 34 | 2025-11-15 | 2026-04-24 |
| Correlation Between the Clinical Presentation of Pulp and the Biological Mediators in Gingival Crevicular Fluid and the Inflamed Pulpal Tissue root canal treatment, samples from Gingival crevicular fluid - Irreversible Pulpitis (Toothache) | Not applicable | Completed | Ain Shams University | 36 | 2025-09-28 | 2026-05-18 |
| Clinical Evaluation of Discoloration Induced by Root Canal Treatment in Vital and Devital Teeth Root Canal Treatment - Tooth Discoloration Following Root Canal Treatment, Tooth Discoloration | Active not recruiting | Marmara University | 52 | 2025-09-16 | 2026-08-27 | |
| Evaluation of the Effect of Salivary Melatonin Levels on Postoperative Pain and Sleep Quality Following Endodontic Treatments Performed at Different Days and Times root canal treatment - Postoperative Pain After Endodontic Treatment | Not applicable | Active not recruiting | Ataturk University | 45 | 2025-09-01 | 2025-09-15 |
| Evaluation of the Success Rate of Pulpotomy Versus to Root Canal Therapy in Management of Mature First Permanent Molars With Irreversible Pulpitis (pulpotomy), root canal treatment - Irreversible Pulpitis (Toothache), Dental Caries (Diagnosis) | Not applicable | Not yet recruiting | Lamiaa Saeed Ahmed Elshiekh | 60 | 2025-07-01 | 2025-07-01 |
| Complete Pulpotomy and Root Canal Treatment Patients With Irreversible Pulpitis With Type 2 Diabetes Mellitus complete pulpotomy, Root canal treatment - Type 2 Diabetes Mellitus (T2DM), Irreversible Pulpitis | Not applicable | Recruiting | Postgraduate Institute of Dental Sciences Rohtak | 106 | 2025-05-01 | 2025-09-09 |
| Evaluation of the Impact of Different Final Irrigation Activation Modes on Healing of Periapical Lesions Related to Permanent Mandibular First Molars Using CBCT. root canal treatment - Necrotic Pulp With Symptomatic Apical Periodontitis | Not applicable | Active not recruiting | Future University in Egypt | 52 | 2025-01-15 | 2026-05-15 |
| Comparative Evaluation of Pediatric Rotary Files and Hand Files in Primary Molars Pulpectomy, Kedo-S Square rotary file, Manual K files - Pulpectomy, Primary Teeth Indicated for Pulp Therapy | Not applicable | Completed | Goa Dental College | 60 | 2025-01-15 | 2026-07-14 |
| Premedication on Post-endodontic Pain Root canal treatment - Premedication | Phase 3 | Recruiting | Gulf Medical University | 48 | 2024-09-01 | 2024-11-04 |
| Evaluation of Pulpotomy Using Two Different Agents in Mature Anterior Teeth With Pulpitis premixed Bioceramic NeoPUTTY®, Biodentine™, Root canal treatment - Pulpitis | Not applicable | Unknown | Ain Shams University | 48 | 2024-07-01 | 2024-06-21 |
| Comparing MTA Pulpotomy to Root Canal Treatment in Management of Permanent Molars With Irreversible Pulpitis in Children MTA Pulpotomy, Root Canal Treatment - Irreversible Pulpitis | Phase 4 | Unknown | Ain Shams University | 62 | 2024-07-01 | 2024-07-05 |
| Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study ROOT CANAL TREATMENT - Rheumatoid Arthritis AND Apical Periodontitis | Not applicable | Unknown | Postgraduate Institute of Dental Sciences Rohtak | 76 | 2024-05-01 | 2024-05-29 |
| Clinical and Radiographic Success of Regeneration Using Injectable Platelet Rich Fibrin Regeneration using Injectable platelet-rich fibrin, Root canal treatment - Apical Periodontitis | Not applicable | Unknown | Cairo University | 50 | 2024-03-01 | 2024-02-09 |
| Prognostic Biomarkers for Pulpotomy Outcome Full pulpotomy, Root canal treatment - Pulpitis - Irreversible | Not applicable | Recruiting | The University of Hong Kong | 192 | 2024-01-01 | 2024-07-23 |
Showing 20 of 46. Sign in to see all of them.
Pain, Postoperative (12) · Periapical Periodontitis (10) · Pulpitis (3) · Dental Caries (2) · Dental Pulp Diseases (2) · Dental Pulp Necrosis (2) · Inflammation (2) · Periapical Abscess (2) · Tooth, Nonvital (2) · Toothache (2) · Acute Pain (1) · Bisphosphonate-Associated Osteonecrosis of the Jaw (1) · Diabetes Mellitus, Type 2 (1) · Disease (1) · Mandibular Nerve Injuries (1)
Postgraduate Institute of Dental Sciences Rohtak (9) · Ain Shams University (5) · Cairo University (5) · Future University in Egypt (2) · King's College London (2) · Marmara University (2) · Mustafa Kemal University (2) · Al-Azhar University (1) · Alanya Alaaddin Keykubat University (1) · Altamash Institute of Dental Medicine (1) · Ataturk University (1) · Bulent Ecevit University (1) · CSI College of Dental Sciences and Research, Madurai (1) · Cittadella Universitaria (1) · Ege University (1)
India (10) · Egypt (9) · Turkey (Türkiye) (7) · Pakistan (2) · United Kingdom (2) · Hong Kong (1) · Italy (1) · Spain (1) · United Arab Emirates (1)
Abeer Elgendy, Professor (1) · Ahmed S Elsheshtawy (1) · Alaa A. Eissa, Msc (1) · Chengfei Zhang (1) · Dr. Sanjay Tewari, MDS (1) · Francesco Mannocci (1) · Hesna Sazak Ovecoglu, DDS, PhD (1) · Huma Tanvir, BDS (1) · Jigyasa Duhan, MDS (1) · Lamia Gadallah, Researcher (1) · Maram F Obeid, Professor (1)
PMID 17956561, PMID 18350967, PMID 19467050, PMID 20663600, PMID 24908421, PMID 27041109, PMID 28198972, PMID 29061359, PMID 29432651, PMID 32989597, PMID 34854987, PMID 35160239, PMID 37080387, PMID 38504243, PMID 39266985, PMID 39325552