22 completed, 6 recruiting, 6 terminated, 3 unknown. 39 Phase 2, 9 Phase 3, 3 Phase 1.
Follow Riluzole: new trials by email Literature Review of Riluzole trials Research Report on Riluzole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral Sclerosis Cyclophosphamide, Riluzole - Amyotrophic Lateral Sclerosis | Phase 2 | Not yet recruiting | Huashan Hospital | 60 | 2026-10-01 | 2026-09-22 |
| Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial Riluzole, Placebo - Breast Cancer, Sarcoma | Phase 2 | Recruiting | University of California, Irvine | 24 | 2025-12-23 | 2026-03-03 |
| PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS Cromolyn Sodium (34.2 mg BID), Cromolyn Sodium (17.1 mg BID), Placebo - Amyotrophic Lateral Sclerosis (ALS) | Phase 2 | Recruiting | PhenoNet, Inc. | 105 | 2025-11-25 | 2026-07-23 |
| Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS) Acetylcysteine, EH301, Riluzole - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Recruiting | Biogipuzkoa Health Research Institute | 90 | 2025-11-25 | 2026-02-17 |
| Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial Riluzole, Placebo - Breast Cancer, Sarcoma | Phase 2 | Recruiting | University of California, Irvine | 75 | 2024-12-02 | 2026-07-14 |
| Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol) IFB-088 50mg/day, Placebo, Riluzole 100mg/day - Amyotrophic Lateral Sclerosis, ALS | Phase 2 | Completed | InFlectis BioScience | 51 | 2022-12-02 | 2025-10-10 |
| RiLuzole to Reduce Atrial FIb Study Using Holter Monitoring Riluzole 50 MG - Atrial Fibrillation Paroxysmal | Phase 2 | Recruiting | University of Utah | 78 | 2022-06-15 | 2023-11-24 |
| Riluzole in Patients With Spinocerebellar Ataxia Type 7 Riluzole, Placebo - SCA7 | Phase 2 / Phase 3 | Recruiting | S. Andrea Hospital | 34 | 2021-06-01 | 2024-12-02 |
| Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy. Riluzole, Placebo Oral Tablet - Oxaliplatin-induced Peripheral Neuropathy | Phase 2 | Suspended | UNICANCER | 80 | 2020-10-28 | 2026-05-20 |
| The Treatment of Amyotrophic Lateral Sclerosis With Huollingshengji Granules Huolingshengji Granules, Riluzole tablet - Amyotrophic Lateral Sclerosis | Phase 2 / Phase 3 | Unknown | Peking University Third Hospital | 144 | 2020-06-01 | 2021-07-08 |
| Trial of Safety, Tolerability and Efficacy of Trametinib (SNR1611) in Patients With Amyotrophic Lateral Sclerosis (ALS) Trametinib (0.5 mg), Trametinib (1 mg), Riluzole (100 mg) - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Terminated | Genuv Inc. | 23 | 2020-04-02 | 2023-05-09 |
| Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition Riluzole, Placebo, Blood Samples - Spinal Cord Injury | Phase 2 | Unknown | Assistance Publique Hopitaux De Marseille | 90 | 2019-05-27 | 2023-04-21 |
| MIROCALS: Modifying Immune Response and OutComes in ALS Riluzole, IL-2, 5% glucose water solution - Amyotrophic Lateral Sclerosis | Phase 2 | Completed | Centre Hospitalier Universitaire de Nīmes | 304 | 2017-06-19 | 2025-12-04 |
| Treatment Effect of Edaravone in Patients With Amyotrophic Lateral Sclerosis (ALS) Edaravone, Riluzole - Neuromuscular Diseases | Phase 2 / Phase 3 | Unknown | Isfahan University of Medical Sciences | 20 | 2017-03-16 | 2019-03-27 |
| MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial Amiloride, Riluzole, Fluoxetine - Secondary Progressive Multiple Sclerosis | Phase 2 | Completed | University College, London | 445 | 2014-12-18 | 2020-03-26 |
| Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) Placebo (for MN-166), MN-166, riluzole - Amyotrophic Lateral Sclerosis | Phase 2 | Completed | MediciNova | 70 | 2014-09-01 | 2021-11-05 |
| Riluzole in Mild Alzheimer's Disease Riluzole, Placebo - Alzheimer's Disease | Phase 2 | Completed | Icahn School of Medicine at Mount Sinai | 50 | 2013-11-01 | 2021-09-22 |
| Riluzole in Spinal Cord Injury Study Riluzole, Placebo - Spinal Cord Injury | Phase 2 / Phase 3 | Terminated | AOSpine North America Research Network | 193 | 2013-10-01 | 2021-04-19 |
| A Pilot Study of Riluzole Versus Placebo in the Treatment of Children and Adolescents With ASD Riluzole, Placebo - Autism Spectrum Disorders | Phase 2 | Completed | Holland Bloorview Kids Rehabilitation Hospital | 58 | 2013-09-01 | 2025-07-16 |
| Safety Study of Riluzole to Treat Post-traumatic Stress Disorder (PTSD) Riluzole, Placebo (for Riluzole) - PTSD | Phase 1 / Phase 2 | Completed | Uniformed Services University of the Health Sciences | 75 | 2013-07-01 | 2021-05-24 |
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Amyotrophic Lateral Sclerosis (15) · Depression (4) · Bipolar Disorder (3) · Colorectal Neoplasms (3) · Depressive Disorder, Major (3) · Autism Spectrum Disorder (2) · Breast Neoplasms (2) · Cerebellar Ataxia (2) · Head and Neck Neoplasms (2) · Liver Neoplasms (2) · Lung Neoplasms (2) · Melanoma (2) · Motor Neuron Disease (2) · Multiple Sclerosis (2) · Obsessive-Compulsive Disorder (2)
National Institute of Mental Health (NIMH) (4) · Cytokinetics (3) · S. Andrea Hospital (3) · University of California, Irvine (2) · Yale University (2) · AB Science (1) · AOSpine North America Research Network (1) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Biogipuzkoa Health Research Institute (1) · Brigham and Women's Hospital (1) · Centre Hospitalier Universitaire de Nīmes (1) · Genuv Inc. (1) · Holland Bloorview Kids Rehabilitation Hospital (1) · Huashan Hospital (1)
United States (22) · France (6) · Canada (4) · Italy (4) · Spain (4) · United Kingdom (3) · Germany (2) · Australia (1) · China (1) · Czechia (1) · Iran (1) · Ireland (1) · Netherlands (1) · Poland (1) · Portugal (1)
Jeremy Shefner, MD, PhD (3) · Alexandre Chan, PharmD, MPH (2) · Jinsy Andrews, MD (2) · Ana Pereira, MD (1) · Benjamin R Brooks, M.D. (1) · Branko Kopjar, MD, PhD (1) · Byoung Joon Kim (1) · Carlos A Zarate, M.D. (1) · Carlos Zarate, MD (1) · Christopher J Pittenger, MD, Ph.D. (1) · David M Benedek, MD (1) · Dongsheng Fan (1) · Ellen Leibenluft, MD (1)
PMID 35092868, PMID 18315448, PMID 20363190, PMID 22985379, PMID 23295632, PMID 23952636, PMID 24356715, PMID 25929276, PMID 26214725, PMID 26321318, PMID 26394202, PMID 28148632, PMID 28338546, PMID 29453787, PMID 30166303, PMID 31182448, PMID 31981516, PMID 33113596, PMID 34145880, PMID 34457038, PMID 35945550, PMID 36662869, PMID 37130044, PMID 37279301, PMID 37794802, PMID 38011420, PMID 39262426, PMID 39446982, PMID 39955416, PMID 40354799, PMID 40398609, PMID 42304135
2015 (1), 2016 (1), 2017 (1), P30CA072720 (1), R34MH083115 (1), U01NS049640 (1)