5 completed, 3 terminated, 2 recruiting, 1 active not recruiting. 13 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 5, Terminated 3, Recruiting 2, Active not recruiting 1, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Terminated 1 |
Follow Riluzole: new trials by email Literature Review of Riluzole trials Research Report on Riluzole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in U.S. Healthy Participants Y-4 tablet, Pregabalin capsule, Riluzole tablet - Healthy Male and Female Subjects | Phase 1 | Not yet recruiting | Neurodawn Pharmaceutical Co., Ltd. | 11 | 2026-06-30 | 2026-06-01 |
| Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS) Acetylcysteine, EH301, Riluzole - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Recruiting | Biogipuzkoa Health Research Institute | 90 | 2025-11-25 | 2026-02-17 |
| Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in Chinese Healthy Subject Y-4 tablet, Pregabalin capsule, Riluzole tablet - Healthy Male and Female Subjects | Phase 1 | Recruiting | Beijing Tiantan Hospital | 10 | 2025-03-28 | 2025-04-20 |
| Evaluate the Safety of Neuronata-R® Inj. Suspended With HypoTHermosol® FRS (HTS-FRS) in Patients With ALS Lenzumestrocel, Riluzole - Amyotrophic Lateral Sclerosis | Phase 1 | Completed | Corestemchemon, Inc. | 8 | 2022-11-09 | 2024-11-06 |
| Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Bevacizumab, Fluorouracil, Leucovorin Calcium - Metastatic Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8 | Phase 1 | Completed | Ning Jin | 13 | 2021-04-02 | 2025-03-28 |
| Riluzole Orodispersible Film Replicate Bioavailability Riluzole 50 mg orodispersible film, Rilutek® 50 mg riluzole tablets - Healthy Participants | Phase 1 | Completed | Cross Research S.A. | 54 | 2021-01-15 | 2025-05-02 |
| Trial of Safety, Tolerability and Efficacy of Trametinib (SNR1611) in Patients With Amyotrophic Lateral Sclerosis (ALS) Trametinib (0.5 mg), Trametinib (1 mg), Riluzole (100 mg) - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Terminated | Genuv Inc. | 23 | 2020-04-02 | 2023-05-09 |
| A Pilot Study Of Riluzole In Patients With Post Traumatic Stress Disorder (PTSD) Riluzole - PTSD | Phase 1 | Completed | Yale University | 18 | 2014-01-01 | 2020-04-01 |
| Safety Study of Riluzole to Treat Post-traumatic Stress Disorder (PTSD) Riluzole, Placebo (for Riluzole) - PTSD | Phase 1 / Phase 2 | Completed | Uniformed Services University of the Health Sciences | 75 | 2013-07-01 | 2021-05-24 |
| Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma Laboratory Biomarker Analysis, Pharmacological Study, Riluzole - Advanced Malignant Solid Neoplasm, Recurrent Melanoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 35 | 2011-02-18 | 2026-09-15 |
| Riluzole and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases riluzole, whole-brain radiation therapy - Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Terminated | Rutgers, The State University of New Jersey | 9 | 2009-11-01 | 2014-05-02 |
| Riluzole in Women With Stage I, Stage II, or Stage IIIA Breast Cancer riluzole, polymorphism analysis, axillary lymph node biopsy - Breast Cancer | Phase 1 | Withdrawn | Barbara Ann Karmanos Cancer Institute | 2009-05-01 | 2013-04-29 | |
| Riluzole in Treating Patients With Stage III or Stage IV Melanoma That Can Be Removed by Surgery riluzole, protein expression analysis, reverse transcriptase-polymerase chain reaction - Melanoma (Skin) | Phase 1 | Terminated | University of Medicine and Dentistry of New Jersey | 15 | 2007-02-01 | 2009-12-11 |
Amyotrophic Lateral Sclerosis (3) · Melanoma (2) · Stress Disorders, Post-Traumatic (2) · Brain Neoplasms (1) · Breast Neoplasms (1) · Colorectal Neoplasms (1) · Neoplasm Metastasis (1) · Neuralgia, Postherpetic (1)
Barbara Ann Karmanos Cancer Institute (1) · Beijing Tiantan Hospital (1) · Biogipuzkoa Health Research Institute (1) · Corestemchemon, Inc. (1) · Cross Research S.A. (1) · Genuv Inc. (1) · National Cancer Institute (NCI) (1) · Neurodawn Pharmaceutical Co., Ltd. (1) · Ning Jin (1) · Rutgers, The State University of New Jersey (1) · Uniformed Services University of the Health Sciences (1) · University of Medicine and Dentistry of New Jersey (1) · Yale University (1)
United States (7) · South Korea (2) · China (1) · Spain (1) · Switzerland (1)
Bruce G. Haffty, MD (1) · Byoung Joon Kim (1) · Chadi Abdallah, MD (1) · David H. Gorski, MD, PhD, FACSw (1) · David M Benedek, MD (1) · James S. Goydos, MD (1) · Janice M Mehnert (1) · Milko Radicioni, MD (1) · Ning Jin, MD (1) · Seung Hyun Kim, MD, PhD (1)
P30CA072720 (3), P30CA022453 (1), R01CA149627 (1), U01CA132194 (1), UM1CA186716 (1)