18 completed, 2 terminated, 2 unknown, 1 withdrawn. 6 Phase 4, 5 Not applicable, 5 Phase 2, 5 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 6 | Completed 4, Terminated 1, Withdrawn 1 |
| Not applicable | 5 | Completed 4, Unknown 1 |
| Phase 2 | 5 | Completed 4, Terminated 1 |
| Phase 3 | 5 | Completed 5 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
Follow Restasis: new trials by email Literature Review of Restasis trials Research Report on Restasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HU007 in Patients with Dry Eye Syndrome HU007, Restasis, Moisview Eye drop - Dry Eye Disease | Phase 3 | Completed | Huons Co., Ltd. | 328 | 2023-03-23 | 2024-09-26 |
| A Feasibility Study to Evaluate the Tolerability of Oph1 Compared to Restasis in Healthy Volunteers Oph1, Restasis - Dry Eye Syndromes | Early Phase 1 | Completed | OphRx Ltd. | 20 | 2023-01-23 | 2024-04-05 |
| Novel Use of Cyclosporine Ophthalmic Emulsion 0.05% in a PROSE Device Restasis - Ocular Surface Disease | Phase 1 / Phase 2 | Completed | Boston Sight | 10 | 2021-07-15 | 2025-01-13 |
| Safety And Effectiveness Of The TearCare® System In The Treatment Of The Signs And Symptoms Of Dry Eye Disease (SAHARA) TearCare System, Cyclosporine Ophthalmic 0.05% Ophthalmic Emulsion - Dry Eye, Meibomian Gland Dysfunction | Not applicable | Completed | Sight Sciences, Inc. | 345 | 2021-04-28 | 2025-11-24 |
| Comparing Treatment of Dry Eye With Intracanalicular Dexamethasone, Restasis, and/or Lotemax Cyclosporine, Loteprednol Etabonate, Dexamethasone Ophthalmic 0.4 Mg Ophthalmic Insert - Dry Eye | Phase 4 | Completed | Thomas Chester, OD | 30 | 2020-10-01 | 2023-10-11 |
| Comparing Effect of Topical Tacrolimus 0.03% Versus Cyclosporine 0.05% in Dry Eyes of Secondary Sjogren Syndrome Cyclosporins, Tacrolimus - Dry Eye, Sjogren Syndrome | Phase 3 | Completed | Pavly Moawd | 60 | 2018-10-30 | 2019-05-22 |
| Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy Tear Film Imager, Restasis - Dry Eye Syndrome, Tear Film Insufficiency | Not applicable | Unknown | Meir Medical Center | 40 | 2018-01-30 | 2018-01-18 |
| Efficacy and Safety of HU007 Eye Drops in Patients With Dry Eye Syndrome HU007, Restasis, Moisview - Dry Eye Syndrome | Phase 3 | Completed | Huons Co., Ltd. | 209 | 2018-01-22 | 2020-05-08 |
| Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome HU00701, HU007, Restasis - Dry Eye Syndrome | Phase 2 | Completed | Huons Co., Ltd. | 114 | 2016-03-01 | 2018-04-12 |
| Efficacy and Safety Study of TJCS for Treatment of Moderate to Severe Dry Eye Syndromes CYPORIN N EYE DROPS 0.05%(TJCS eye drop), Restasis - Dry Eye Syndromes | Phase 3 | Completed | Taejoon Pharmaceutical Co., Ltd. | 158 | 2014-01-01 | 2015-06-03 |
| A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate Ophthalmic Gel 0.5% on the Initiation of Dry Eye Treatment With Restasis® Loteprednol etabonate, Artificial Tears, Restasis - Dry Eye Disease | Phase 4 | Withdrawn | Edward Holland, MD | 2014-01-01 | 2015-03-18 | |
| Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease) Lotemax, Restasis, Soothe® Lubricant Eye Drops - Keratoconjunctivitis Sicca | Phase 2 | Completed | Bausch & Lomb Incorporated | 102 | 2013-05-17 | 2019-08-30 |
| Efficacy and Safety of HE10 for Dry Eye Syndrome HE 10, Restasis - Dry Eye Syndrome | Phase 3 | Completed | Huons Co., Ltd. | 101 | 2013-05-01 | 2015-07-08 |
| Identification and Validation of Functional Biomarkers for Keratoconus Cyclosporins - Keratoconus | Unknown | Narayana Nethralaya | 200 | 2013-04-01 | 2014-03-06 | |
| Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease Restasis, Refresh Endura - Primary Sjogren Syndrome, Secondary Sjogren Syndrome | Phase 4 | Completed | Federal University of São Paulo | 100 | 2013-01-01 | 2020-09-22 |
| Treatment of Ocular Graft-versus-Host Disease (GVHD) With Topical Loteprednol Etabonate 0.5% Lotemax, Restasis - Dry Eyes | Not applicable | Completed | University of Michigan | 75 | 2011-08-01 | 2015-09-24 |
| Topical Cyclosporine Suspension for the Treatment of Brittle Nails topical cyclosporine ophthalmic suspension 0.05%, vehicle - Brittle Nail Syndrome | Phase 2 | Completed | University of North Carolina, Chapel Hill | 21 | 2010-02-01 | 2017-03-13 |
| Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease Euphrasia-based homeopathic therapy, Cyclosporin solution - Dry Eye Syndromes | Phase 2 | Terminated | University of Missouri-Columbia | 7 | 2007-12-01 | 2017-01-12 |
| Topical Cyclosporine and Disease Progression Restasis, Endura - Disease Progression, Disease Severity | Phase 4 | Completed | Innovative Medical | 80 | 2007-12-01 | 2008-09-25 |
| Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Cyclosporin 0.05% ophthalmic - Atopic Keratoconjunctivitis | Not applicable | Completed | Johns Hopkins University | 12 | 2007-08-01 | 2018-04-02 |
Showing 20 of 23. Sign in to see all of them.
Dry Eye Syndromes (17) · Keratoconjunctivitis Sicca (3) · Graft vs Host Disease (2) · Disease Progression (1) · Glaucoma (1) · Keratoconjunctivitis (1) · Keratoconus (1) · Lacrimal Apparatus Diseases (1) · Meibomian Gland Dysfunction (1) · Sjogren's Syndrome (1) · Twenty-Nail Dystrophy (1) · Xerophthalmia (1)
Huons Co., Ltd. (4) · Bausch & Lomb Incorporated (1) · Boston Sight (1) · Edward Holland, MD (1) · Federal University of São Paulo (1) · Innovative Medical (1) · Johns Hopkins University (1) · Massachusetts Eye and Ear Infirmary (1) · Meir Medical Center (1) · Narayana Nethralaya (1) · OphRx Ltd. (1) · Ophthalmic Consultants of Long Island (1) · Pavly Moawd (1) · Sight Sciences, Inc. (1) · Taejoon Pharmaceutical Co., Ltd. (1)
United States (12) · South Korea (4) · Brazil (1) · Egypt (1) · India (1) · Israel (1)
Aida Lugo-Somolinos, MD (1) · Choun-Ki Joo (1) · Daniel C Brocks, MD (1) · Esen K Akpek, MD (1) · Fani Segev, M.D. (1) · Gaafar Ragab (1) · Jaime Dickerson, PhD (1) · Lenworth N Johnson, MD (1) · Maria Howard (1) · Marlene R. Moster, MD (1) · Namsick Kim (1) · Omar El Zawahry (1) · Rehab Shamma (1) · Reza Dana, M.D. (1)
PMID 20092592, PMID 25083776, PMID 25648341, PMID 33449860, PMID 33530719, PMID 40719437