23 completed, 8 recruiting, 3 unknown, 2 active not recruiting. 28 Not applicable, 7 Phase 3, 3 Phase 2, 1 Phase 1.
Follow Prolonged Exposure: new trials by email Literature Review of Prolonged Exposure trials Research Report on Prolonged Exposure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RECONNECT - Treatments for Complex PTSD Prolonged Exposure, EMDR, ESTAIR - Complex Post-Traumatic Stress Disorder (CPTSD) | Not applicable | Not yet recruiting | University of Copenhagen | 225 | 2027-07-31 | 2026-10-07 |
| Two-week Intensive Outpatient Trauma Treatment. Prolonged exposure and EMDR - Posttraumatic Stress Disorder (PTSD) | Not applicable | Recruiting | Oslo University Hospital | 42 | 2026-01-26 | 2026-05-04 |
| Evaluating Evidenced Based Options for PTSD Treatment Cognitive Processing Therapy, Prolonged Exposure, Skills Training for Affective and Interpersonal Regulation - PTSD - Post Traumatic Stress Disorder | Not applicable | Recruiting | Rush University Medical Center | 400 | 2025-10-06 | 2026-10-28 |
| PS-Trauma - Development of Trauma Treatment for Patients With Co-morbid Psychotic Disorders and Traumas Prolonged Exposure, EMDR - SCHIZOPHRENIA 1 (Disorder), Schizotypal Disorder | Not applicable | Recruiting | Nikolai Albert | 20 | 2025-10-02 | 2025-12-10 |
| MDMA-assisted Massed Prolonged Exposure for PTSD 3,4 Methylenedioxymethamphetamine, Prolonged Exposure - Post-Traumatic Stress Disorder | Phase 3 | Active not recruiting | Healing Breakthrough | 20 | 2024-10-25 | 2026-08-26 |
| Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD Prolonged exposure - PTSD, Suicidal Ideation | Not applicable | Recruiting | Ohio State University | 100 | 2024-02-26 | 2026-06-29 |
| Effectiveness of Trauma Therapy Using Prolonged Exposure for Patients With PTSD and a Comorbid Psychotic Disorder Prolonged Exposure - Post Traumatic Stress Disorder, PTSD | Not applicable | Recruiting | Medicalschool Hamburg | 56 | 2023-05-15 | 2023-09-21 |
| Mechanisms Underlying Efficacy of Prolonged Exposure Prolonged Exposure - Post Traumatic Stress Disorder | Not applicable | Recruiting | Massachusetts General Hospital | 50 | 2023-04-01 | 2025-11-13 |
| Blended Treatment för PTSD: A New Format of Computer-Assisted Trauma-Focused Cognitive Behavioral Therapy Blended Trauma focused Cognitive Behavioral Therapy (B-Tf-CBT), Prolonged exposure - PTSD, CBT | Not applicable | Recruiting | Karolinska Institutet | 160 | 2023-03-10 | 2025-12-26 |
| 8-day Intensive Treatment Programme for PTSD and CPTSD in Sweden Intensive treatment programme, Treatment as Usual (TAU) - PTSD, Complex Post-Traumatic Stress Disorder | Not applicable | Active not recruiting | Christina Blomdahl | 118 | 2021-08-01 | 2025-06-27 |
| Effectiveness of Trauma Therapy in Patients With PTSD and Comorbid Psychotic Disorder Prolonged Exposure - Post Traumatic Stress Disorder, Psychotic Disorders | Not applicable | Unknown | University of Hamburg-Eppendorf | 100 | 2021-01-20 | 2021-06-02 |
| A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel Exposure Therapy, Interpersonal Psychotherapy - PTSD | Not applicable | Recruiting | Weill Medical College of Cornell University | 208 | 2020-03-09 | 2026-04-16 |
| Cannabidiol and Prolonged Exposure Prolonged Exposure, Cannabidiol, placebo - PTSD | Phase 2 | Completed | VA Office of Research and Development | 136 | 2019-10-01 | 2026-10-28 |
| Peer Social Support During In Vivo Exposure for PTSD Prolonged Exposure - Stress Disorders, Post-Traumatic, Anxiety Disorders | Not applicable | Completed | Medical University of South Carolina | 109 | 2018-05-01 | 2024-08-16 |
| Topiramate and Prolonged Exposure topiramate, prolonged exposure, placebo - PTSD and Alcohol Use Disorder | Phase 2 / Phase 3 | Completed | VA Office of Research and Development | 100 | 2017-11-01 | 2023-11-18 |
| Virtual Reality Exposure Therapy for Combat Prolonged Exposure, Virtual Reality Exposure Therapy - PTSD | Not applicable | Unknown | Bar-Ilan University, Israel | 40 | 2016-12-01 | 2018-02-19 |
| Improving PTSD Treatments for Adults With Childhood Trauma Trauma-focused treatment, Emotion regulation training, Intensive Trauma-focused treatment - Post Traumatic Stress Disorder | Not applicable | Completed | Leiden University | 150 | 2016-12-01 | 2021-02-18 |
| Evaluating the Feasibility of RESCUE: An Adjunctive HAI-Based Intervention for Veterans With PTSD RESCUE, Prolonged Exposure - PTSD | Not applicable | Completed | Charleston Research Institute | 57 | 2016-09-27 | 2020-01-22 |
| Biomarker Establishment for Superior Treatment of PTSD Psychotherapy - PTSD | Completed | Stanford University | 292 | 2016-09-01 | 2020-02-12 | |
| Comparative Effectiveness of Two Treatments for Veterans With PTSD Interpersonal Therapy for PTSD, Prolonged Exposure - Posttraumatic Stress Disorder | Not applicable | Completed | VA Office of Research and Development | 115 | 2016-09-01 | 2021-07-07 |
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Stress Disorders, Post-Traumatic (36) · Anxiety Disorders (7) · Wounds and Injuries (4) · Alcoholism (3) · Combat Disorders (3) · Motor Activity (3) · Schizophrenia (3) · Depression (2) · Psychotic Disorders (2) · Stress Disorders, Traumatic (2) · Substance-Related Disorders (2) · Affective Symptoms (1) · Aggression (1) · Behavior, Addictive (1) · Cigarette Smoking (1)
VA Office of Research and Development (4) · Medical University of South Carolina (2) · Stanford University (2) · University of Puerto Rico (2) · University of Texas at Austin (2) · Association for Children at Risk (1) · Bar-Ilan University, Israel (1) · Charleston Research Institute (1) · Christina Blomdahl (1) · HaEmek Medical Center, Israel (1) · Healing Breakthrough (1) · Karolinska Institutet (1) · Leiden University (1) · Massachusetts General Hospital (1) · Medicalschool Hamburg (1)
United States (25) · Israel (3) · Germany (2) · Norway (2) · Puerto Rico (2) · Sweden (2) · Denmark (1) · Netherlands (1)
Alan Schatzberg, MD (1) · Amanda W Baker, Ph.D. (1) · Amit Etkin, M.D., Ph.D. (1) · Anouk Grubaugh, PhD (1) · Asle Hoffart, PhD (1) · Brian Martis, MD (1) · Candice M Monson, PhD (1) · Catherine R Ayers, PhD (1) · Christina Blomdahl, PhD (1) · David W. Oslin, MD (1) · Edna B Foa, Ph.D. (1) · Jaryd Hiser, Ph.D. (1) · JoAnn Difede, PhD (1) · Julian Ford, Ph.D. (1) · Julie H Evensen, MD PhD (1)
PMID 25706090, PMID 17327524, PMID 22639402, PMID 24434093, PMID 24700623, PMID 27444425, PMID 28221062, PMID 28715907, PMID 28715908, PMID 30449712, PMID 30529244, PMID 30541492, PMID 30576030, PMID 31872563, PMID 31881993, PMID 32345329, PMID 34051626, PMID 34630934, PMID 34881912, PMID 38843038, PMID 42313651, PMID 42780432
I01RX001783 (1), R01AA016816 (1), R01DA023507 (1)