6 recruiting, 5 unknown, 4 not yet recruiting, 3 completed. 7 Phase 4, 6 Not applicable, 2 Phase 3, 1 Phase 2.
Follow PCSK9 inhibitor: new trials by email Literature Review of PCSK9 inhibitor trials Research Report on PCSK9 inhibitor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PCSK9 Inhibitors in Acute Ischemic Stroke Patients Undergoing Endovascular Therapy PCSK9 inhibitor - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 478 | 2025-09-15 | 2025-09-15 |
| Single Dose PCSK9 Inhibitor to Improve Cardiovascular Outcomes After PCI: A Pilot Study PCSK9 inhibitor, Standard Lipid-Lowering Therapy - Coronary Artery Disease | Phase 4 | Not yet recruiting | Hanyang University Seoul Hospital | 352 | 2025-07-01 | 2025-07-24 |
| Assessing Coronary Non-Culprit Plaque Early with Start of PCSK9 Inhibitors in Acute Myocardial Infarction (ACCESS-AMI) PCSK9 inhibitor, Statin+ezetimibe, Blood lipid levels meet the recommended guidelines - Acute Myocardial Infarction | Not applicable | Not yet recruiting | Yun Dai Chen | 300 | 2025-04-15 | 2025-03-03 |
| Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII) PCSK9 inhibitor, Statin - Myocardial Ischaemic Syndrome, Coronary Heart Disease | Not applicable | Not yet recruiting | Nanjing Medical University | 400 | 2025-01-01 | 2024-12-12 |
| Multicenter Real-World Cohort Study Evaluating the Impact of Early Intensive Lipid-Lowering Therapy on the Prognosis of Acute Coronary Syndrome Patients(ELITE-ACS) PCSK9 inhibitor, Statin+Ezetimibe/Hybutimibe compound, Statin - Acute Coronary Syndromes | Recruiting | Yun Dai Chen | 6000 | 2024-12-16 | 2025-03-17 | |
| Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke Statins and/or Ezetimibe, PCSK9 inhibitor - Ischemic Stroke, Small Vessel Cerebrovascular Disease | Not applicable | Recruiting | Seoul National University Hospital | 4016 | 2024-10-04 | 2026-09-11 |
| Effect of PCSK9 Inhibitors on Coronary Atherosclerotic Plaques Derived From Optical Coherence Tomography PCSK9 inhibitor, Statin - Coronary Artery Disease, Optical Coherence Tomography | Phase 4 | Recruiting | First Affiliated Hospital of Xinjiang Medical University | 396 | 2024-07-01 | 2024-08-19 |
| Exploratory Research of PCSK9 Inhibitor on Patency of aAVF After PTA With PCB pcsk9 inhibitor - Hemodialysis Access Failure | Not applicable | Unknown | RenJi Hospital | 40 | 2023-09-10 | 2023-09-13 |
| Effect of Evolocumab on Chronic Total Occlusions (EVOLO-CTO) PCSK9 inhibitor, Statin - In-stent Restenosis, Major Adverse Cardiovascular Events | Phase 4 | Unknown | Lin Zhao | 200 | 2022-12-15 | 2023-11-13 |
| Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome PCSK9 inhibitor - Intracranial Artery Stenosis | Not applicable | Recruiting | Nanjing First Hospital, Nanjing Medical University | 180 | 2022-05-23 | 2026-04-15 |
| Low-dose PCSK9 Inhibitor Combined With Stains on Serum Lipids in Chinese Population With Acute Coronary Syndrome Statin, PCSK9 inhibitor - Acute Coronary Syndrome | Phase 4 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 100 | 2022-04-01 | 2022-03-28 |
| Efficacy and Safety of Pitavastatin and PCSK9 Inhibitors in Liver Transplant Patients Pitavastatin, PCSK9 inhibitor - Dyslipidemias, Hyperlipidemias | Phase 4 | Active not recruiting | National Medical Research Center for Therapy and Preventive Medicine | 59 | 2021-10-01 | 2025-01-22 |
| Impact of Optimal Pharmacotherapy on Lipid Profile and Qualitative Features of Atherosclerotic Plaques Inclisiran - Atherosclerotic Cardiovascular Disease | Unknown | Pauls Stradins Clinical University Hospital | 50 | 2021-06-29 | 2023-11-22 | |
| Acute Myocardial Infarction and Unstable Angina Patients With PCSK9 Inhibitor Usage Study PCSK9 inhibitor - Lipid Metabolism, Cardiovascular Diseases | Not applicable | Unknown | Shenzhen People's Hospital | 100 | 2021-04-22 | 2022-05-05 |
| Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis carotid artery stenting, carotid endarterectomy, Aspirin - Ischemic Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis) | Recruiting | Tongji Hospital | 1000 | 2021-03-01 | 2024-06-20 | |
| CHOlesterol Lowering and Residual Risk in Type 2 Diabetes Statin, PCSK9 inhibitor, Ezetimibe 10mg - Type 2 Diabetes | Phase 4 | Completed | NYU Langone Health | 151 | 2020-08-12 | 2024-10-17 |
| Study to Evaluate Changes in Cognitive Function in Patients Treated With PCSK9 Inhibitors PCSK9 inhibitor - Cognitive Function, Hypercholesterolemia | Completed | Jose Seijas Amigo | 180 | 2020-03-01 | 2023-01-17 | |
| Effect of Evolocumab on Coronary Atherosclerosis Evolocumab, 18F-NaF PET, CCTA - Cardiovascular Disease, Hyperlipidemia | Phase 3 | Completed | Cedars-Sinai Medical Center | 55 | 2019-03-19 | 2024-07-17 |
| The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques Atorvastatin Calcium, Probucol, PCSK9 inhibitor - Stroke, Ischemic, Atherosclerosis, Cerebral | Phase 4 | Recruiting | General Hospital of Shenyang Military Region | 100 | 2018-12-01 | 2026-04-27 |
Ischemic Stroke (4) · Cardiovascular Diseases (3) · Acute Coronary Syndrome (2) · Coronary Artery Disease (2) · Hyperlipidemias (2) · Atherosclerosis (1) · Cerebral Small Vessel Diseases (1) · Coronary Disease (1) · Diabetes Mellitus, Type 2 (1) · Dyslipidemias (1) · Embolism (1) · Hypercholesterolemia (1) · Inflammation (1) · Intracranial Arteriosclerosis (1) · Stroke (1)
Yun Dai Chen (2) · Cedars-Sinai Medical Center (1) · First Affiliated Hospital of Xinjiang Medical University (1) · General Hospital of Shenyang Military Region (1) · Hanyang University Seoul Hospital (1) · Jose Seijas Amigo (1) · Lin Zhao (1) · NYU Langone Health (1) · Nanfang Hospital, Southern Medical University (1) · Nanjing First Hospital, Nanjing Medical University (1) · Nanjing Medical University (1) · National Medical Research Center for Therapy and Preventive Medicine (1) · Pauls Stradins Clinical University Hospital (1) · RenJi Hospital (1) · Seoul National University Hospital (1)
China (12) · United States (2) · Latvia (1) · Russia (1) · South Korea (1) · Spain (1)
Alexandra Ershova, PhD (1) · Chuan Qin, Dr. (1) · Dai-Shi Tian, Dr. (1) · Daniel S. Berman, MD (1) · Huisheng Chen, Doctor (1) · Jeffrey Berger, MD (1) · Jun Xiao, Dr. (1) · Karlis Trusinskis, MD (1) · Ke Shang, Dr. (1) · Lin Zhao, MD (1) · Lu-yao Ma, MD (1) · Seung-Hoon Lee, MD, PhD (1) · Tangzhiming Li, PhD. (1) · Zhenyan Fu, PhD (1)
PMID 33197560, PMID 35606883, PMID 36017088, PMID 37612529, PMID 37666281, PMID 38337601, PMID 39452487, PMID 40178463, PMID 40288288, PMID 41847515, PMID 42047198, PMID 42089099, PMID 42137728