17 recruiting, 11 active not recruiting, 3 completed, 3 not yet recruiting. 18 Phase 3, 14 Phase 2, 3 Early Phase 1, 3 Not applicable, 2 Phase 4.
Follow Patient Observation: new trials by email Literature Review of Patient Observation trials Research Report on Patient Observation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information Biospecimen Collection, Chest Radiography, Computed Tomography - Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8 | Phase 2 | Recruiting | Children's Oncology Group | 51 | 2027-05-15 | 2026-09-24 |
| Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial Atezolizumab, Atezolizumab and Recombinant Human Hyaluronidase, Biospecimen Collection - Lung Non-Small Cell Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2027-03-02 | 2026-10-22 |
| Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain Biospecimen Collection, Low-Dose Aspirin, Patient Observation - Endometrial Carcinoma | Phase 4 | Not yet recruiting | Mayo Clinic | 20 | 2027-02-12 | 2026-08-05 |
| Testing the Investigational Medication Pembrolizumab After Kidney Removal for Patients With Non-Clear Cell Renal Cell Carcinoma Biospecimen Collection, Bone Scan, Computed Tomography - Non-Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 | Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 400 | 2027-02-10 | 2026-07-08 |
| Comparing Radiation After Surgery to Observation After Surgery in Patients With Clinical Low-Risk, Molecular High-Risk Meningioma, and Evaluating Observation After Surgery in Patients With Clinical and Molecular Low-Risk Meningioma Patient Observation, Magnetic Resonance Imaging, Biospecimen Collection - Grade 1 Meningioma, Grade 2 Meningioma | Phase 3 | Not yet recruiting | NRG Oncology | 464 | 2027-01-28 | 2026-08-25 |
| Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment Zanidatamab, Resection, Patient Observation - Colon Carcinoma, Colorectal Carcinoma | Phase 2 | Recruiting | Emory University | 38 | 2026-04-07 | 2026-04-17 |
| Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease Biospecimen Collection, Dasatinib, Fisetin - Glioma | Early Phase 1 | Recruiting | Mayo Clinic | 30 | 2025-08-12 | 2026-10-01 |
| Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial Best Practice, Biospecimen Collection, Bone Metastases Treatment - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 3 | Active not recruiting | NRG Oncology | 280 | 2025-05-07 | 2026-08-17 |
| A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) Bone Scan, Carboplatin, Computed Tomography - Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor | Phase 3 | Recruiting | Children's Oncology Group | 1656 | 2025-04-15 | 2026-08-25 |
| Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial Biospecimen Collection, Computed Tomography, Durvalumab - Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 306 | 2025-04-01 | 2026-10-19 |
| Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma Biospecimen Collection, Bone Scan, Computed Tomography - Pleuropulmonary Blastoma | Phase 3 | Recruiting | Children's Oncology Group | 110 | 2025-03-21 | 2026-08-25 |
| Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance Biopsy of Prostate, Biospecimen Collection, Magnetic Resonance Imaging - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Phase 4 | Recruiting | Roswell Park Cancer Institute | 600 | 2025-01-15 | 2026-05-14 |
| Active Surveillance for the Treatment of Low-Risk Basal Cell Carcinoma in Elderly Patients Best Practice, Educational Activity, Patient Observation - Skin Basal Cell Carcinoma | Not applicable | Active not recruiting | University of Michigan Rogel Cancer Center | 81 | 2024-10-08 | 2026-06-23 |
| Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial Abiraterone, Apalutamide, Biospecimen Collection - Recurrent Castration-Sensitive Prostate Carcinoma, Recurrent Prostate Cancer | Phase 2 | Recruiting | Mayo Clinic | 532 | 2024-06-03 | 2026-07-20 |
| Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer Chemotherapy, Patient Observation, Questionnaire Administration - Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8 | Early Phase 1 | Recruiting | M.D. Anderson Cancer Center | 120 | 2024-03-13 | 2026-05-20 |
| Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy Biopsy, Biospecimen Collection, Computed Tomography - Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Primary Mediastinal Large B-Cell Lymphoma | Phase 2 | Recruiting | Academic and Community Cancer Research United | 120 | 2024-01-31 | 2024-09-26 |
| Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma Zanubrutinib, Rituximab, Patient Observation - Mantle Cell Lymphoma | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 421 | 2023-10-20 | 2026-10-02 |
| Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer Encorafenib, Cetuximab, Biospecimen Collection - Colon Adenocarcinoma, Microsatellite Stable Colon Carcinoma | Phase 2 / Phase 3 | Active not recruiting | Alliance for Clinical Trials in Oncology | 1 | 2023-08-16 | 2026-07-02 |
| Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab Pembrolizumab, Patient Observation, Biopsy - Anatomic Stage II Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 1295 | 2023-06-14 | 2026-08-05 |
| Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma Axicabtagene Ciloleucel, Biospecimen Collection, Computed Tomography - Diffuse Large B-Cell Lymphoma, Grade 3b Follicular Lymphoma | Phase 2 | Recruiting | SWOG Cancer Research Network | 396 | 2023-06-12 | 2026-10-15 |
Showing 20 of 37. Sign in to see all of them.
Colonic Neoplasms (3) · Prostatic Neoplasms (3) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Lymphoma, Large B-Cell, Diffuse (2) · Melanoma (2) · Oropharyngeal Neoplasms (2) · Rectal Neoplasms (2) · Anal Canal Carcinoma (1) · Anus Neoplasms (1) · Brain Neoplasms (1) · Breast Carcinoma In Situ (1) · Carcinoma, Basal Cell (1) · Cardiotoxicity (1)
National Cancer Institute (NCI) (10) · Mayo Clinic (5) · Children's Oncology Group (4) · Alliance for Clinical Trials in Oncology (3) · NRG Oncology (3) · M.D. Anderson Cancer Center (2) · Roswell Park Cancer Institute (2) · SWOG Cancer Research Network (2) · Academic and Community Cancer Research United (1) · City of Hope Medical Center (1) · ECOG-ACRIN Cancer Research Group (1) · Emory University (1) · University of Michigan Rogel Cancer Center (1) · University of Utah (1)
United States (35) · Canada (9) · Puerto Rico (5) · Australia (2) · New Zealand (2) · Saudi Arabia (2) · Israel (1) · South Korea (1)
Ahmed Aly (1) · Alexander Shoushtari (1) · Allison Billi (1) · Brian T Hess (1) · Brittani K Seynnaeve (1) · Christopher C. DeStephano, MD, MPH (1) · Clayton S Lau (1) · Daniel J. Ma, M.D. (1) · David B Zhen (1) · Elizabeth A Mullen (1) · Erin F Gillespie (1) · Geoffrey T Gibney (1) · George Chang (1) · Gregory M Tiao (1) · Grzegorz S Nowakowski (1)
PMID 33526329, PMID 38942046, PMID 39390760, PMID 40029972, PMID 41693026, PMID 41825136, PMID 42117295, PMID 42335416
U10CA180820 (6), U10CA180886 (4), U10CA180888 (4), U10CA180821 (2), P30CA015083 (1), P30CA016056 (1), P30CA033572 (1), P30CA042014 (1), P30CA138292 (1), R01CA286127 (1), R01CA300454 (1), U10CA180868 (1), UG1CA189867 (1), UG1CA189974 (1)