16 completed, 8 unknown, 5 not yet recruiting, 5 recruiting. 23 Not applicable, 3 Early Phase 1, 3 Phase 1, 3 Phase 4, 2 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Papaverine and Sublingual Microcirculation in Septic Shock Papaverine - Septic Shock, Microcirculatory Dysfunction | Not applicable | Not yet recruiting | First Affiliated Hospital of Wannan Medical College | 20 | 2026-08-01 | 2026-06-18 |
| Effect of Short Foot Exercise Combined With Focused Hip and Knee Exercises on Pain, Q Angle and Functional Outcomes in Female Patients With Patellofemoral Pain Syndrome Short foot exercise + Hip and Knee Strengthening exercise, Hip and Knee Strengthening Exercises - Patellofemoral Pain Syndrome | Not applicable | Not yet recruiting | Lahore University of Biological and Applied Sciences | 38 | 2026-07-18 | 2026-07-14 |
| Papaverine for Prevention of Perineal Trauma Papaverine Hydrochloride, Placebo - Perineal Trauma, Obstetric Anal Sphincter Injury | Not applicable | Not yet recruiting | Dr Raneen Abu Shqara | 412 | 2026-06-03 | 2026-06-11 |
| A Single-Arm, Prospective Study of Papaverine for the Treatment of Refractory Peripheral Neuropathy Induced by Taxane-Based Chemotherapy Papaverine hydrochloride injection - Chemotherapy-Induced Peripheral Neuropathy, Refractory Chemotherapy-Induced Peripheral Neuropathy | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 43 | 2026-05-01 | 2026-05-07 |
| Effects of Hip and Ankle Mobility Rehabilitation in Male Collegiate Athletes With Patellofemoral Pain Hip- and Ankle-Mobility-Based Rehabilitation Program - Patellofemoral Pain | Not applicable | Completed | Beijing Sport University | 48 | 2026-01-15 | 2026-04-30 |
| Core and Hip-Knee Exercises in PFPS Core Muscle Stability Exercise Program, hip and knee-focused exercise program - Pain, DKV | Not applicable | Completed | Cairo University | 36 | 2025-05-01 | 2026-07-01 |
| Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter Papaverine 80 mg IV, Placebo (Normal Saline) - Labor, Induced | Not applicable | Recruiting | Hillel Yaffe Medical Center | 184 | 2025-04-22 | 2026-01-06 |
| Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial Biospecimen Collection, Computed Tomography, Consolidation Therapy - Locally Advanced Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8 | Phase 1 | Recruiting | City of Hope Medical Center | 36 | 2025-04-07 | 2026-07-22 |
| Implementing a Guideline-based Model of Care for Hip and Knee Osteoarthritis in Finland. A Benchmarking-controlled Trial (FIN-OA) Implementation of a guideline-based model of care for hip and knee osteoarthritis - Osteoarthritis of the Hip or Knee | Not yet recruiting | University of Jyvaskyla | 10000 | 2025-04-01 | 2025-04-03 | |
| Effects of Pelvic Tilt Exercises Along With Hip and Knee Focused Exercises on Patients With Patellofemoral Pain Syndrome Pelvic Tilt, Hip and Knee Focused Exercises (Intervention Group), Hip and Knee Focused Exercises(Control Group) - Patellofemoral Pain Syndrome | Not applicable | Active not recruiting | Superior University | 48 | 2025-03-20 | 2025-04-06 |
| Intravenous Papaverine for Term Prelabor Rupture of Membranes Papaverine, Normal Saline Placebo Infusion - Premature Rupture of Fetal Membranes | Not applicable | Recruiting | Wolfson Medical Center | 200 | 2025-03-20 | 2026-09-17 |
| Papaverine and Oxytocin vs Oxytocin Alone in Labor Induction Papaverine, normal saline - Induced; Birth, Labor Onset and Length Abnormalities | Not applicable | Unknown | Western Galilee Hospital-Nahariya | 126 | 2024-09-01 | 2024-09-19 |
| IV PAPAVERINE Prior to Propess for Labor Induction Papaverine, placebo - Induced Vaginal Delivery | Phase 4 | Completed | Western Galilee Hospital-Nahariya | 110 | 2024-08-12 | 2025-06-26 |
| Determining the Impact of a Physiotherapist-Led Primary Care Model for Hip and Knee Pain - A Pilot Trial Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain - Hip Osteoarthritis, Knee Osteoarthritis | Not applicable | Completed | Jordan Miller, PT, PhD | 205 | 2023-10-02 | 2025-03-20 |
| Determining the Impact of a Physiotherapist-led Primary Care Model for Hip and Knee Pain - A Cluster Trial Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain - Hip Osteoarthritis, Knee Osteoarthritis | Not applicable | Completed | Queen's University | 647 | 2023-10-02 | 2026-08-12 |
| Knee Strengthening With Hip vs. Ankle Exercises in Women With Patellofemoral Pain Syndrome hip + knee joint exercise group, ankle + knee joint exercise group, Stretching group - Patellofemoral Pain Syndrome, Anterior Knee Pain | Not applicable | Completed | Kaohsiung Medical University Chung-Ho Memorial Hospital | 45 | 2023-07-01 | 2025-10-07 |
| The Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography Papaverine Hydrochloride, normal saline - Radial Artery Spasm | Phase 2 | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 240 | 2023-05-24 | 2023-06-12 |
| The Effect of IV PAPAVERINE 80 mg Prior to Catheter Balloon Insertion on Bishop Score and Pain IV Papaverine 80 mg, Placebo - Induction of Labor, Pain, Acute | Not applicable | Unknown | Western Galilee Hospital-Nahariya | 128 | 2023-05-15 | 2023-06-29 |
| Neuromuscular Training Compared to Progressive Resistance Training for Patients With Anterior Knee Pain Neuromuscular Training exercises, Hip and Knee Muscular Strength exercises - Anterior Knee Pain Syndrome | Not applicable | Unknown | University of Thessaly | 50 | 2023-02-02 | 2023-10-31 |
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Patellofemoral Pain Syndrome (8) · Osteoarthritis, Hip (5) · Motor Activity (3) · Osteoarthritis (3) · Osteoarthritis, Knee (3) · Acute Pain (1) · Agnosia (1) · Alzheimer Disease (1) · Anxiety Disorders (1) · Carcinoma, Non-Small-Cell Lung (1) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Emergencies (1) · Fetal Membranes, Premature Rupture (1) · Gastroenteritis (1)
Western Galilee Hospital-Nahariya (3) · Cairo University (2) · Ohio State University Comprehensive Cancer Center (2) · Asan Medical Center (1) · Beijing Sport University (1) · City of Hope Medical Center (1) · Dr Raneen Abu Shqara (1) · European University Cyprus (1) · First Affiliated Hospital of Wannan Medical College (1) · Hadassah Medical Organization (1) · Hillel Yaffe Medical Center (1) · Hospital de Clinicas de Porto Alegre (1) · Imperial College London (1) · Joint Academy (1) · Jordan Miller, PT, PhD (1)
United States (9) · Israel (5) · China (3) · Canada (2) · Denmark (2) · Egypt (2) · Pakistan (2) · Sweden (2) · Brazil (1) · Cyprus (1) · Greece (1) · Norway (1) · South Korea (1) · Taiwan (1) · United Kingdom (1)
Jordan Miller, PhD (2) · Aaron J Krych (1) · Abdallah Ali (1) · Antonis Constantinou, PhDcan (1) · Bob Oranje, PHD (1) · Carolina S Umpierres, Bachelor (1) · Christopher G. Wood, MD (1) · Dimitris Stasinopoulos, PhD (1) · Einar Lindalen, MD (1) · Esther Maor-Sagie, MD (1) · Jeremey Brownstein, MD (1) · Jeremy Brownstein, MD (1) · Leif E Dahlberg (1) · Maya Frank Wolf, MD (1)
PMID 18783876, PMID 22141334, PMID 22873940, PMID 25685352, PMID 25856757, PMID 26078452, PMID 26419897, PMID 30646197, PMID 37026831, PMID 38561773, PMID 38825005, PMID 39443927, PMID 40930776, PMID 41366694, PMID 42172602, PMID 42355539
P30CA016672 (1), P30CA033572 (1), P50CA090270 (1), R01CA262388 (1), R01CA297752 (1)