17 not yet recruiting, 9 recruiting, 6 completed, 3 active not recruiting. 16 Not applicable, 9 Phase 4, 5 Phase 2, 3 Phase 1, 2 Phase 3.
Follow Normal Saline (0.9% NaCl): new trials by email Literature Review of Normal Saline (0.9% NaCl) trials Research Report on Normal Saline (0.9% NaCl)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Magnesium Sulfate in Pediatric Burn Dressing Changes magnesium sulfate, Normal Saline (0.9% NaCl) - Pediatric Burns | Phase 1 | Not yet recruiting | Hennepin Healthcare Research Institute | 10 | 2027-12-01 | 2026-10-09 |
| Effect Of Intracuff Dexamethasone On Postoperative Sore Throat In Patients Undergoing Laparoscopic Cholecystectomy Dexamethasone (0.1 mg/kg), Normal Saline (0.9% NaCl) - Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Not yet recruiting | B.P. Koirala Institute of Health Sciences | 40 | 2027-01-01 | 2026-08-24 |
| The Use of Tranexamic Acid in Decreasing Wound Complication in Total Ankle Replacement. Transexamic acid, Normal Saline (0.9% NaCl) - Ankle Arthritis, Wound Complication | Phase 2 | Not yet recruiting | Ottawa Hospital Research Institute | 40 | 2026-12-01 | 2026-10-22 |
| Ulinastatin on Systemic Immune-Inflammation in Patients With Complicated Intra-Abdominal Infection ulinastatin, Normal Saline (0.9% NaCl) - Complicated Intra-abdominal Infection (cIAI), Systemic Inflammatory Response | Not applicable | Not yet recruiting | Fujian Medical University Union Hospital | 165 | 2026-10-30 | 2026-06-29 |
| Evaluating the Effectiveness and Safety of Microneedling With Topical Tranexamic Acid in Treatment of Striae Rubra Topical tranexamic acid, normal saline (0.9% NaCl) - Striae Rubra | Not applicable | Not yet recruiting | Sohag University | 50 | 2026-10-01 | 2026-09-10 |
| DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) Dexmedetomidine, Normal Saline (0.9% NaCl) - Neurosurgery, Brain Cancer | Not applicable | Not yet recruiting | University of Malaya | 60 | 2026-07-22 | 2026-02-09 |
| Clinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Combined With Sodium Hyaluronate Intravesical Instillation in the Treatment of Radiation Cystitis Exosomes (hUC-MSC-Exo), Sodium Hyaluronate (Hyalein), Normal Saline (0.9% NaCl) - Radiation Cystitis | Early Phase 1 | Not yet recruiting | Fujian Medical University Union Hospital | 48 | 2026-07-20 | 2026-07-08 |
| Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to Standard Treatment for Treatment-Resistant Major Depression in the Brazilian Public Health System (SUS) Tocilizumab, Normal Saline (0.9% NaCl) - Treatment-Resistant Major Depressive Disorder | Phase 2 | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 32 | 2026-07-01 | 2026-05-15 |
| Dose-Response Interaction of Metoprolol and Sufentanil for Attenuating Hemodynamic Responses in Tracheal Intubation Metoprolol (MET), Sufentanil, Normal Saline (0.9% NaCl) - General Anesthesia; Tracheal Intubation | Phase 4 | Not yet recruiting | Fujian Provincial Hospital | 900 | 2026-06-22 | 2026-05-20 |
| ITX24-01 in Adult Male and Female Patients With Select Types of Severe Chronic Neck- and Lower Back Pain ITX24-01, Normal Saline (0.9% NaCl) - Facet Joint Pain | Phase 1 | Not yet recruiting | Interventional AnalgesiX Inc. | 32 | 2026-06-01 | 2026-04-09 |
| Effect of Lidocaine Through Gastric Tube on PONV Lidocaine, Normal Saline (0.9% NaCl) - PONV | Not applicable | Recruiting | General Hospital of Ningxia Medical University | 100 | 2026-05-20 | 2026-06-11 |
| Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl) - Critical Illness, Depressive Symptoms | Phase 2 | Recruiting | Hospital Italiano de Buenos Aires | 50 | 2026-05-14 | 2026-09-02 |
| The Effect of a Single Intravenous Injection of Esketamine During Cesarean Section on Postoperative Pruritus in Patients With Intrahepatic Cholestasis of Pregnancy Normal Saline (0.9% NaCl), Esketamine 0.3mg/kg - Intrahepatic Cholestasis of Pregnancy | Not applicable | Not yet recruiting | Tianjin Medical University General Hospital | 160 | 2026-05-05 | 2026-05-01 |
| Augmentation of Arthroscopic Rotator Cuff Repair With Reimplantation of Subacromial Bursa Tissue and Platelet-Rich Plasma Subacromial Bursa Tissue Reimplantation, Arthroscopic Rotator Cuff Repair, Platelet-Rich Plasma (PRP) Injections - Cuff Injury, Rotator, Arthroscopic Surgical Procedures | Not applicable | Not yet recruiting | National and Kapodistrian University of Athens | 200 | 2026-05-01 | 2026-05-19 |
| Exosome Therapy for Male Androgenetic Alopecia Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes, Normal Saline (0.9% NaCl) - Androgenetic Alopecia (AGA) | Phase 2 | Recruiting | Zhang Han | 120 | 2026-04-30 | 2026-07-09 |
| Difelikefalin for Itching in Hemodialysis Patients With Chronic Kidney Disease Difelikefalin Injection, Normal Saline (0.9% NaCl) - Itching Symptoms, CKD 5D, Hemodialysis | Not applicable | Not yet recruiting | Chittagong Medical College | 106 | 2026-04-26 | 2026-04-13 |
| A Phase 1 Study of PVT401 in Healthy Subjects PVT401, Normal Saline (0.9% NaCl) - Inflammatory Bowel Disease (IBD) | Phase 1 | Recruiting | Parvus Therapeutics, Inc. | 36 | 2026-04-13 | 2026-09-30 |
| Dex & Mastectomy Pain Dexamethasone (intravenous), Normal Saline (0.9% NaCl) - Post-Mastectomy Chronic Pain Syndrome | Phase 4 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 170 | 2026-04-13 | 2026-06-04 |
| Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery Lidocaine %2 ampoule, Normal Saline (0.9% NaCl) - Congenital Heart Disease, Postoperative Pulmonary Complications | Phase 4 | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 320 | 2026-04-01 | 2026-03-30 |
| Synergistic Effect of Intravenous Lidocaine on Anesthetic Induction and Emergence in Patients Undergoing Laparoscopic Cholecystectomy or Gynecological Surgery Normal Saline (0.9% NaCl), Lidocaine, Lidocaine Bolus + Infusion - Cholecystectomy, Laparoscopic, Gynecologic Surgical Procedures | Not applicable | Enrolling by invitation | General Hospital of Ningxia Medical University | 195 | 2025-09-25 | 2025-09-26 |
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Acute Lung Injury (1) · Agnosia (1) · Alopecia (1) · Ascites (1) · Back Pain (1) · Brain Injuries, Traumatic (1) · Brain Neoplasms (1) · Burns (1) · Chronic Pain (1) · Cough (1) · Craniocerebral Trauma (1) · Critical Illness (1) · Delirium (1) · Depression (1) · Fibrosis (1)
Fujian Medical University Union Hospital (2) · General Hospital of Ningxia Medical University (2) · Al-Quds University (1) · Anahita Rabiee MD MHS (1) · Andrew G Hill, MBChB, MD (Thesis), EdD, FACS, FRACS (1) · B.P. Koirala Institute of Health Sciences (1) · CMH Multan Institute of Medical Sciences (1) · Chang Gung Memorial Hospital (1) · China-Japan Friendship Hospital (1) · Chittagong Medical College (1) · Fujian Provincial Hospital (1) · Hennepin Healthcare Research Institute (1) · Hospital Italiano de Buenos Aires (1) · Hospital Universitario de Caracas (1) · Hospital de Clinicas de Porto Alegre (1)
China (9) · United States (6) · Taiwan (3) · Australia (2) · Canada (2) · Egypt (2) · Argentina (1) · Brazil (1) · New Zealand (1) · Pakistan (1) · Palestinian Territories (1) · Turkey (Türkiye) (1) · Venezuela (1)
Abeer J Dar Hasan, MD (1) · Ahmed Said Elgebaly, professor (1) · Akshitkumar Mistry, MD (1) · Andriani Zafeiri (1) · Bradley Meulenkamp, MD MSc FRCSC (1) · Devang K Sanghavi, M.B.B.S., M.D. (1) · Federico Carini, M.D. (1) · Guolin Wang (1) · Ivan A Huespe, M.D., M.P.H. (1) · Jacob T Munro, MBChB, FRACS (1) · Katie P Wu, MD (1) · Krishna Pokharel (1) · Matthew Wilkinson, MD, MPH (1) · Mohammed M Maree, MD (1) · Monika KC (1)
PMID 12518122, PMID 14982564, PMID 16923481, PMID 19140238, PMID 19410035, PMID 19670137, PMID 23982301, PMID 24650832, PMID 25088919, PMID 25579870, PMID 25683315, PMID 28662956, PMID 30979521, PMID 32733363, PMID 32943462, PMID 33022440, PMID 33189715, PMID 33302662, PMID 33387333, PMID 34963021, PMID 34970147, PMID 34992482, PMID 36357803, PMID 36454569, PMID 37658717, PMID 39028048, PMID 39840843, PMID 42285573