1065 completed, 368 unknown, 145 terminated, 97 recruiting. 554 Not applicable, 461 Phase 4, 435 Phase 2, 328 Phase 3, 215 Phase 1.
Follow this drug Literature Review of Normal Saline trials Research Report on Normal Saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| A Study to Determine the Safety and Efficacy of TG-C in Subjects With Symptomatic Early Hip Osteoarthritis TG-C, Placebo Control - Degenerative Osteoarthritis | Phase 2 | Not yet recruiting | Kolon TissueGene, Inc. | 255 | 2027-10-01 | 2026-08-20 |
| GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease | Phase 3 | Not yet recruiting | Samsung Pharmaceutical Co., Ltd. | 750 | 2027-07-01 | 2026-06-10 |
| Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS Normal Saline, Centhaquine - Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Not yet recruiting | Pharmazz, Inc. | 80 | 2027-05-01 | 2026-09-17 |
| Challenge Trial of PfSPZ-LARC2 Vaccine in Burkina Faso PfSPZ-LARC2 Vaccine, PfSPZ Challenge, Normal Saline - Malaria (Plasmodium Falciparum) | Phase 1 | Not yet recruiting | Sanaria Inc. | 45 | 2027-03-01 | 2026-07-31 |
| A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent Normal Saline, Centhaquine - Hypovolemic Shock | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 430 | 2027-02-01 | 2026-09-17 |
| A Phase 1 Clinical Trial of Adjuvanted Protein-based HCV Vaccine Candidates (HCV Vaccine Trial) AVIHepC1, Normal Saline - Hepatitis C | Phase 1 | Not yet recruiting | University of Alberta | 27 | 2027-01-15 | 2026-09-25 |
| Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia colistimethate sodium, 0.9% Saline - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Not yet recruiting | University Hospital Fattouma Bourguiba | 400 | 2027-01-01 | 2026-10-08 |
| Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage Normal Saline, Nicardipine - Subarachnoid Hemorrhage | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 214 | 2027-01-01 | 2026-10-01 |
| The Effects of Timolol On Healing and Cosmesis of Mohs Scalp Wounds: An Open Label Trial Topical Timolol, Normal Saline - Surgical Wounds, Mohs Surgery | Phase 2 | Not yet recruiting | Geisinger Clinic | 45 | 2026-12-01 | 2026-10-14 |
| Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2) Tirofiban, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Not yet recruiting | Dr David Hasan, M.D. | 82 | 2026-11-05 | 2026-10-19 |
| Impact of Intravenous Dexamethasone on the Duration of Motor and Sensory Block Following Spinal Anesthesia With Chloroprocaine Intravenous Dexamethasone, Normal Saline - Spinal Anesthesia, Prolonged Sensory Block | Not applicable | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 60 | 2026-11-01 | 2026-10-08 |
| Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department. Ketamine (1 mg/kg), propofol, Dexmedetomidine - Procedural Sedation | Phase 4 | Not yet recruiting | Sultan Qaboos University | 100 | 2026-10-10 | 2026-10-15 |
| Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty Tranexamic Acid, Normal Saline - Knee Osteoarthritis | Phase 4 | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 70 | 2026-10-01 | 2026-10-09 |
| Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery Dex-Esk, Placebo, Active tDCS - Older Patients, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 1996 | 2026-10-01 | 2026-10-13 |
| PEDIatric Cardiac Dysfunction Treated With Injectable Nicotinamide Adenine Dinucleotide Placebo, Nicotinamide Adenine Dinucleotide - Cardiac Dysfunction | Phase 2 | Not yet recruiting | Beijing Children's Hospital | 180 | 2026-10-01 | 2026-09-24 |
| Intrauterine G-CSF Infusion for Thin Endometrium Granulocyte Colony-Stimulating Factor(G-CSF), Normal Saline - Thin Endometrium, Female Infertility | Phase 3 | Not yet recruiting | Nanjing University | 620 | 2026-10-01 | 2026-07-09 |
| RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion) - Perineal Trauma, Postpartum Pain | Not applicable | Not yet recruiting | University Hospital, Geneva | 160 | 2026-10-01 | 2026-07-27 |
| Effect of Post-Radiofrequency Corticosteroid Injection on the Incidence of Post-Neurotomy Neuritis Dexamethasone, Normal Saline, Bupivacaine - Facet Joint Pain, Arthropathy | Phase 2 | Enrolling by invitation | Siriraj Hospital | 126 | 2026-10-01 | 2026-09-28 |
| Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery. liposomal bupivacaine, Normal Saline - Acute Pain, Orthopaedic Surgery | Phase 4 | Not yet recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 668 | 2026-10-01 | 2026-09-02 |
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Pain, Postoperative (105) · Pain (95) · Agnosia (45) · Emergence Delirium (39) · COVID-19 (34) · Sepsis (34) · Acute Kidney Injury (33) · Osteoarthritis (28) · Shock, Septic (28) · Hemorrhage (27) · Postoperative Nausea and Vomiting (24) · Premature Birth (23) · Breast Neoplasms (20) · Malaria (20) · Osteoarthritis, Knee (19)
Assiut University (45) · Seoul National University Hospital (33) · Peking University First Hospital (32) · Yonsei University (30) · Ain Shams University (23) · Allergan (22) · Cairo University (21) · Tanta University (20) · Mayo Clinic (15) · General Hospital of Ningxia Medical University (14) · Johns Hopkins University (14) · Northwestern University (14) · Sanaria Inc. (14) · Tianjin Medical University General Hospital (14) · Chang Gung Memorial Hospital (13)
United States (618) · China (253) · South Korea (163) · Egypt (158) · Canada (142) · Taiwan (60) · United Kingdom (48) · Australia (41) · Thailand (36) · Pakistan (27) · Germany (26) · Turkey (Türkiye) (24) · France (23) · Denmark (20) · Saudi Arabia (20)
Dong-Xin Wang, MD, PhD (25) · Omar Soliman, MD (6) · Yung-Tsan Wu, MD (6) · Dong-Xin Wang, MD,PhD (5) · Guolin Wang (5) · Guolin Wang, MD (5) · Patrick E Duffy, M.D. (5) · Michael W Donnino, MD (4) · Xiaochun Zheng, MD (4) · Hemant Misra, PhD (3) · Jian-Xin Zhou, MD (3) · Moon Jong Noh, PhD (3)
PMID 39428602, PMID 37870112, PMID 39301879, PMID 16275600, PMID 18809959, PMID 19478674, PMID 21300053, PMID 21623291, PMID 21675055, PMID 22939099, PMID 23741350, PMID 24052307, PMID 24754838, PMID 25184864, PMID 25932413, PMID 26220293, PMID 26231052, PMID 26305798, PMID 26807124, PMID 27488394, PMID 28183547, PMID 28279391, PMID 28302179, PMID 28369198, PMID 28778254, PMID 29253090, PMID 29485925, PMID 29784145, PMID 30116551, PMID 30339737, PMID 32665528, PMID 33196806, PMID 34002866, PMID 34473343, PMID 34704710, PMID 34887657, PMID 35443809, PMID 37302963, PMID 38743692, PMID 38987318, PMID 39153490, PMID 40337980, PMID 10077078, PMID 10214567, PMID 10227938, PMID 10231466, PMID 10365009, PMID 10433490, PMID 10484524, PMID 10502118
2014 (7), 2015 (5), 2017 (4), 2016 (3), 2023 (3), 2019 (2), 2025 (2), K23DA029609 (2), U01HL077863 (2), 1UG3HL147011-01A1 (1), 2008 (1), 2009 (1), 5KL2TR002379 (1), 5KL2TR002379-08 (1), K23AR079044 (1)