1070 completed, 365 unknown, 147 terminated, 99 recruiting. 557 Not applicable, 463 Phase 4, 438 Phase 2, 328 Phase 3, 217 Phase 1.
Follow Normal Saline: new trials by email Literature Review of Normal Saline trials Research Report on Normal Saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| A Study to Determine the Safety and Efficacy of TG-C in Subjects With Symptomatic Early Hip Osteoarthritis TG-C, Placebo Control - Degenerative Osteoarthritis | Phase 2 | Not yet recruiting | Kolon TissueGene, Inc. | 255 | 2027-10-01 | 2026-08-20 |
| GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease | Phase 3 | Not yet recruiting | Samsung Pharmaceutical Co., Ltd. | 750 | 2027-07-01 | 2026-06-10 |
| Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS Normal Saline, Centhaquine - Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Not yet recruiting | Pharmazz, Inc. | 80 | 2027-05-01 | 2026-09-17 |
| Challenge Trial of PfSPZ-LARC2 Vaccine in Burkina Faso PfSPZ-LARC2 Vaccine, PfSPZ Challenge, Normal Saline - Malaria (Plasmodium Falciparum) | Phase 1 | Not yet recruiting | Sanaria Inc. | 45 | 2027-03-01 | 2026-07-31 |
| A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent Normal Saline, Centhaquine - Hypovolemic Shock | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 430 | 2027-02-01 | 2026-09-17 |
| Umbilical Cord-derived Mesenchymal Stem Cell Injectables for the Regeneration of Partial-thickness Rotator Cuff Tears umbilical cord-derived mesenchymal stem cell, Normal Saline - Rotator Cuff Disease | Not applicable | Not yet recruiting | Kyoung Hwan Koh | 38 | 2027-02-01 | 2026-11-09 |
| A Phase 1 Clinical Trial of Adjuvanted Protein-based HCV Vaccine Candidates (HCV Vaccine Trial) AVIHepC1, Normal Saline - Hepatitis C | Phase 1 | Not yet recruiting | University of Alberta | 27 | 2027-01-15 | 2026-09-25 |
| Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia colistimethate sodium, 0.9% Saline - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Not yet recruiting | University Hospital Fattouma Bourguiba | 400 | 2027-01-01 | 2026-10-08 |
| Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage Normal Saline, Nicardipine - Subarachnoid Hemorrhage | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 214 | 2027-01-01 | 2026-10-01 |
| Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2) Tirofiban, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Not yet recruiting | Dr David Hasan, M.D. | 82 | 2026-12-05 | 2026-11-04 |
| The Effects of Timolol On Healing and Cosmesis of Mohs Scalp Wounds: An Open Label Trial Topical Timolol, Normal Saline - Surgical Wounds, Mohs Surgery | Phase 2 | Not yet recruiting | Geisinger Clinic | 45 | 2026-12-01 | 2026-10-14 |
| Effect of Midazolam Given at Induction on Recall of Propofol Injection Pain Midazolam, Lidocaine Hydrochloride 2%, Propofol 1% - Propofol Injection Pain, Postoperative Recall of Pain | Phase 4 | Not yet recruiting | Atlas University | 150 | 2026-12-01 | 2026-11-03 |
| Phase 2 Evaluation of Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB) Injection for the Treatment of Infraorbital Hollowing RhPDGF-BB, Normal Saline - Infra-orbital Hollows, Skin Quality Improvement | Phase 2 | Not yet recruiting | Lynch Regenerative Medicine | 75 | 2026-11-09 | 2026-11-04 |
| Impact of Intravenous Dexamethasone on the Duration of Motor and Sensory Block Following Spinal Anesthesia With Chloroprocaine Intravenous Dexamethasone, Normal Saline - Spinal Anesthesia, Prolonged Sensory Block | Not applicable | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 60 | 2026-11-01 | 2026-10-08 |
| Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients Sodium Acetate, Placebo - Alcohol Withdrawal, Alcohol Abstinence | Phase 1 / Phase 2 | Not yet recruiting | University of Colorado, Denver | 75 | 2026-11-01 | 2026-10-30 |
| Esketamine Combined With Transcutaneous Electrical Acupoint Stimulation on Postoperative Recovery Quality After Elective Cesarean Section Esketamine, Active TEAS, Normal Saline - Cesarean Section (MeSH: D002585), Postoperative Pain After Cesarean Section | Not applicable | Not yet recruiting | Anhui Provincial Hospital | 384 | 2026-10-30 | 2026-11-04 |
| Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula - Melasma (Facial Melasma) | Phase 4 | Enrolling by invitation | Sameh Sarsik | 80 | 2026-10-25 | 2026-10-27 |
| Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department. Ketamine (1 mg/kg), propofol, Dexmedetomidine - Procedural Sedation | Phase 4 | Not yet recruiting | Sultan Qaboos University | 100 | 2026-10-10 | 2026-10-15 |
| Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty Tranexamic Acid, Normal Saline - Knee Osteoarthritis | Phase 4 | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 70 | 2026-10-01 | 2026-10-09 |
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Pain, Postoperative (107) · Pain (95) · Agnosia (45) · Emergence Delirium (39) · COVID-19 (34) · Sepsis (34) · Acute Kidney Injury (33) · Osteoarthritis (28) · Shock, Septic (28) · Hemorrhage (27) · Postoperative Nausea and Vomiting (24) · Premature Birth (23) · Breast Neoplasms (20) · Malaria (20) · Osteoarthritis, Knee (19)
Assiut University (45) · Seoul National University Hospital (33) · Peking University First Hospital (32) · Yonsei University (30) · Ain Shams University (23) · Allergan (22) · Cairo University (22) · Tanta University (20) · Mayo Clinic (15) · General Hospital of Ningxia Medical University (14) · Johns Hopkins University (14) · Northwestern University (14) · Sanaria Inc. (14) · Tianjin Medical University General Hospital (14) · Chang Gung Memorial Hospital (13)
United States (619) · China (253) · South Korea (163) · Egypt (159) · Canada (142) · Taiwan (60) · United Kingdom (48) · Australia (41) · Thailand (36) · Pakistan (27) · Germany (26) · Turkey (Türkiye) (26) · France (23) · Denmark (20) · Saudi Arabia (20)
Dong-Xin Wang, MD, PhD (25) · Omar Soliman, MD (6) · Yung-Tsan Wu, MD (6) · Dong-Xin Wang, MD,PhD (5) · Guolin Wang (5) · Guolin Wang, MD (5) · Patrick E Duffy, M.D. (5) · Michael W Donnino, MD (4) · Xiaochun Zheng, MD (4) · Hemant Misra, PhD (3) · Jian-Xin Zhou, MD (3) · Moon Jong Noh, PhD (3)
PMID 39428602, PMID 37870112, PMID 39301879, PMID 16275600, PMID 18809959, PMID 19478674, PMID 21300053, PMID 21623291, PMID 21675055, PMID 22939099, PMID 23741350, PMID 24052307, PMID 24754838, PMID 25184864, PMID 25932413, PMID 26220293, PMID 26231052, PMID 26305798, PMID 26807124, PMID 27488394, PMID 28183547, PMID 28279391, PMID 28302179, PMID 28369198, PMID 28778254, PMID 29253090, PMID 29485925, PMID 29784145, PMID 30116551, PMID 30339737, PMID 32665528, PMID 33196806, PMID 34002866, PMID 34473343, PMID 34704710, PMID 34887657, PMID 35443809, PMID 37302963, PMID 38743692, PMID 38987318, PMID 39153490, PMID 40337980, PMID 10077078, PMID 10214567, PMID 10227938, PMID 10231466, PMID 10365009, PMID 10433490, PMID 10484524, PMID 10502118
2014 (7), 2015 (5), 2017 (4), 2016 (3), 2023 (3), 2019 (2), 2025 (2), K23DA029609 (2), U01HL077863 (2), 1UG3HL147011-01A1 (1), 2008 (1), 2009 (1), 5KL2TR002379 (1), 5KL2TR002379-08 (1), K23AR079044 (1)