27 completed, 14 recruiting, 8 active not recruiting, 4 terminated. 26 Phase 2, 20 Not applicable, 7 Phase 1, 4 Early Phase 1, 4 Phase 4.
Follow Nicotinamide Riboside: new trials by email Literature Review of Nicotinamide Riboside trials Research Report on Nicotinamide Riboside
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Topical Niacinamide Riboside on the Signs of Facial Skin Aging Topical niacinamide riboside, Placebo - Skin Aging on Face, Skin Care Dermocosmetics | Not applicable | Recruiting | ChromaDex, Inc. | 140 | 2026-08-17 | 2026-08-21 |
| Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial) Nicotinamide Riboside, Pterostilbene - Clonal Cytopenia of Undetermined Significance, Myelodysplastic Syndrome | Phase 2 | Recruiting | University of Colorado, Denver | 10 | 2026-05-20 | 2026-06-03 |
| Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis Zinc, Placebos for zinc and nicotinamide riboside, Nicotinamide riboside - Idiopathic Pulmonary Fibrosis | Phase 2 | Recruiting | Cedars-Sinai Medical Center | 60 | 2025-11-03 | 2025-11-10 |
| Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment Nicotinamide Riboside, Placebo, Vitrectomy and Gas tamponade - Retinal Detachment | Phase 4 | Recruiting | Center for Eye Research Australia | 144 | 2025-09-19 | 2026-03-23 |
| Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide - Glaucoma | Phase 2 | Recruiting | Christopher Kai Shun Leung | 138 | 2025-05-19 | 2025-06-26 |
| ACEs, SIRT1, and Premature Vascular Aging in Humans Nicotinamide Riboside, Placebo - Adverse Childhood Experiences, Endothelial Dysfunction | Not applicable | Recruiting | University of Wisconsin, Madison | 30 | 2025-03-27 | 2026-08-19 |
| Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery Nicotinamide riboside, Placebo - Acute Kidney Injury, Cardiac Valve Disease | Not applicable | Unknown | Instituto Nacional de Cardiologia Ignacio Chavez | 100 | 2024-07-24 | 2024-07-25 |
| Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside Nicotinamide riboside - Ataxia Telangiectasia | Not applicable | Unknown | The University of Queensland | 10 | 2024-05-01 | 2024-04-18 |
| Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus Nicotinamide Riboside - Systemic Lupus Erythematosus (Sle) | Phase 1 / Phase 2 | Recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 78 | 2024-03-13 | 2026-07-31 |
| The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism Nicotinamide Riboside, Placebo - Progressive Supranuclear Palsy, Multiple System Atrophy | Phase 2 | Recruiting | Haukeland University Hospital | 330 | 2024-03-05 | 2025-01-10 |
| Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate Standard Diet, Ketogenic Diet, Placebo - Overweight, Obesity | Not applicable | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 100 | 2024-01-08 | 2026-09-18 |
| Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans Nicotinamide Riboside, Placebo - Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration | Not applicable | Active not recruiting | VA Office of Research and Development | 74 | 2023-09-01 | 2026-07-21 |
| A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy Nicotinamide Riboside, Placebo - Mitochondrial Myopathy | Phase 2 | Active not recruiting | Ralitza Gavrilova | 34 | 2023-05-26 | 2026-01-26 |
| The Effect of NAD Supplementation on Brain Vascular Health in Aging Nicotinamide riboside, Placebo - Aging | Phase 4 | Recruiting | University of Oklahoma | 214 | 2023-05-03 | 2026-04-01 |
| Benefits of Nicotinamide Riboside Upon Cognition and Sleep Nicotinamide riboside, Placebo - Cognitive Impairment, Sleep Quality | Not applicable | Recruiting | State University of New York at Buffalo | 50 | 2023-04-04 | 2026-09-24 |
| Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients Nicotinamide Riboside, Placebo - Breast Cancer, Metastatic Breast Cancer | Phase 2 | Recruiting | University Hospital, Akershus | 60 | 2023-03-16 | 2023-03-17 |
| NAD Supplementation and Vascular Health in PAD Nicotinamide riboside - Peripheral Artery Disease | Phase 1 / Phase 2 | Completed | University of Oklahoma | 8 | 2023-02-27 | 2026-04-06 |
| Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors Nicotinamide Riboside, Placebo, Exercise Intervention - Lymphoblastic Leukemia, Cancer Survivors | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 80 | 2023-02-23 | 2025-12-04 |
| N-DOSE: A Dose Optimization Trial of Nicotinamide Riboside in Parkinson's Disease Nicotinamide Riboside, Placebo - Parkinson Disease | Phase 2 | Completed | Haukeland University Hospital | 81 | 2023-01-23 | 2025-07-08 |
| NOPARK Open Label Extension Study Nicotinamide Riboside - Safety Issues | Not applicable | Active not recruiting | Haukeland University Hospital | 400 | 2022-09-28 | 2025-05-30 |
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Parkinson Disease (5) · Cognitive Dysfunction (3) · Heart Failure (3) · Obesity (3) · Sarcopenia (3) · Acute Kidney Injury (2) · Ataxia Telangiectasia (2) · COVID-19 (2) · Frailty (2) · Heart Failure, Systolic (2) · Hypertension (2) · Inflammation (2) · Mitochondrial Diseases (2) · Mitochondrial Myopathies (2) · Myelodysplastic Syndromes (2)
Haukeland University Hospital (6) · University of Washington (5) · National Heart, Lung, and Blood Institute (NHLBI) (3) · University of Copenhagen (3) · Children's Hospital of Philadelphia (2) · Donna Hammond, PhD (2) · Mayo Clinic (2) · Mclean Hospital (2) · The University of Texas Health Science Center at San Antonio (2) · University of Colorado, Denver (2) · University of Oklahoma (2) · Aarhus University Hospital (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Cedars-Sinai Medical Center (1) · Center for Eye Research Australia (1)
United States (36) · Norway (8) · Denmark (4) · Australia (2) · United Kingdom (2) · Hong Kong (1) · Mexico (1) · Netherlands (1) · South Africa (1)
Charalampos Tzoulis, MD, PhD (3) · Charalampos Tzoulis, PhD (3) · Kevin D O'Brien, MD (3) · Andriy Yabluchanskiy, MD, PhD (2) · Rachael J Klein, M.D. (2) · Ahmet Hoke (1) · Alexandra Thomas, MD (1) · Amanpreet Cheema, PhD (1) · Baback Roshanravan, MD (1) · Becky Powers, M.D. (1) · Brent A Bauer, MD (1) · Brent Forester, MD, MSc (1) · Bryan Kestenbaum, MD (1)
PMID 41264372, PMID 42063312, PMID 10693811, PMID 21110941, PMID 21651395, PMID 23782899, PMID 25386668, PMID 27127236, PMID 28869251, PMID 29211728, PMID 29599478, PMID 30127395, PMID 31673160, PMID 32790648, PMID 32791973, PMID 33393613, PMID 35235774, PMID 35620522, PMID 35854224, PMID 36588397, PMID 36644285, PMID 37159264, PMID 37994989, PMID 38016950, PMID 39548320, PMID 39847432, PMID 40739200, PMID 41357333, PMID 42009009, PMID 42035974, PMID 42048163, PMID 42848371
R21HL126209 (2), 2023 (1), 3UH3DK114920-04S2 (1), P30CA033572 (1), R01AG066670 (1), R01CA254955 (1), R01DK101509 (1), R01DK121516 (1), R01HL144937 (1), R01HL149722 (1), R21CA208968 (1)