8 completed, 2 terminated, 1 unknown. 11 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 8, Terminated 2, Unknown 1 |
| Phase 2 | 6 | Completed 3, Terminated 2, Unknown 1 |
Follow NaCl 0.9%: new trials by email Literature Review of NaCl 0.9% trials Research Report on NaCl 0.9%
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study. Antioxidant therapy, NaCl 0.9% - Acute Myocardial Infarction, Ischemia-reperfusion Injury | Phase 1 | Completed | University of Chile | 18 | 2022-08-09 | 2024-01-12 |
| HAT for the Treatment of Sepsis Associated With NASTI HAT, Placebo - Necrotizing Soft Tissue Infection, Sepsis | Phase 1 / Phase 2 | Terminated | Ascension Health | 10 | 2021-09-10 | 2024-07-24 |
| Cell Therapy Using Umbilical Cord-derived Mesenchymal Stromal Cells in SARS-CoV-2-related ARDS Umbilical cord Wharton's jelly-derived human, NaCl 0.9% - Severe Acute Respiratory Syndrome Coronavirus 2, Severe Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 47 | 2020-04-06 | 2022-02-18 |
| Cardiac Safety Evaluation of P03277 P03277 0.1 mmol/kg, Moxifloxacin 400mg, NaCl 0.9% - Healthy Volunteers | Phase 1 | Completed | Guerbet | 48 | 2017-08-21 | 2022-07-18 |
| FEIBA and Use of Blood Products in Cardiac Surgery FEIBA, Normal Saline - Cardiovascular Disease | Phase 1 | Completed | Oregon Health and Science University | 12 | 2016-02-01 | 2020-07-14 |
| Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS) Iron infusion, Normal saline infusion - Postural Orthostatic Tachycardia Syndrome | Phase 1 / Phase 2 | Terminated | Mayo Clinic | 3 | 2014-12-17 | 2017-11-17 |
| Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions P03277, Placebo - Healthy Volunteers, Brain Lesion | Phase 1 / Phase 2 | Completed | Guerbet | 142 | 2013-11-25 | 2021-05-14 |
| Brain Ketone Metabolism in Type 1 Diabetes Beta-hydroxybutyrate, Normal Saline - Type 1 Diabetes, Hypoglycemia | Phase 1 | Completed | Yale University | 44 | 2013-05-14 | 2023-04-27 |
| A Proof of Concept Study to Determine the Local Delivery and Efficacy of Nanocort Nanocort, Methylprednisolone, Placebo - Atherosclerosis | Phase 1 / Phase 2 | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 21 | 2012-05-01 | 2012-07-23 |
| Cutaneous Iontophoresis of Iloprost and Treprostinil in Healthy Volunteers treprostinil, iloprost, NaCl 0.9% - Healthy | Phase 1 / Phase 2 | Completed | University Hospital, Grenoble | 20 | 2010-01-01 | 2011-10-06 |
| Placebo-Controlled Crossover Study for the Investigation of the Effect of Pantoprazole on Cardiac Contractility Pantoprazole, Placebo - Healthy | Phase 1 | Completed | Herzzentrum Goettingen | 20 | 2005-05-01 | 2009-03-24 |
Atherosclerosis (1) · COVID-19 (1) · Cardiovascular Diseases (1) · Diabetes Mellitus, Type 1 (1) · Hypoglycemia (1) · Myocardial Reperfusion Injury (1) · Postural Orthostatic Tachycardia Syndrome (1) · Reperfusion Injury (1) · Respiratory Distress Syndrome (1) · Sepsis (1)
Guerbet (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Ascension Health (1) · Assistance Publique - Hôpitaux de Paris (1) · Herzzentrum Goettingen (1) · Mayo Clinic (1) · Oregon Health and Science University (1) · University Hospital, Grenoble (1) · University of Chile (1) · Yale University (1)
United States (4) · Belgium (2) · France (2) · Chile (1) · Germany (1) · Netherlands (1)
Abraham IJ Gajardo, MD, PhD (1) · Amie Jones, MD (1) · E S Stroes, MD PhD (1) · Frederic Vanhoutte, MD (1) · Gerd Hasenfuss, Prof. Dr. (1) · Raimund Herzog, MD (1) · Thomas Resch, M.D. (1) · Wouter Haazen, MD (1)
PMID 19301059, PMID 23400744, PMID 30870257, PMID 34215339, PMID 34774107, PMID 35189925, PMID 38973337
2004 (1), 2009 (1), R01DK101984 (1)