63 completed, 18 unknown, 12 terminated, 2 active not recruiting. 30 Phase 2, 29 Phase 4, 26 Phase 3, 15 Not applicable, 11 Phase 1.
Follow NaCl 0.9%: new trials by email Literature Review of NaCl 0.9% trials Research Report on NaCl 0.9%
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery Tranexamic Acid (Topical), Normal Saline (Placebo) - Cesarean Delivery, Postpartum Hemorrhage (PPH) | Early Phase 1 | Recruiting | Wolfson Medical Center | 112 | 2026-07-01 | 2026-07-02 |
| Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty NaCl 0.9%, Dexamethasone 4mg - Osteoarthritis, Knee, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 90 | 2025-09-13 | 2026-05-22 |
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Tranexamic Acid in Vaginal Reconstructive Surgery Tranexamic acid, Vasopressin, NaCl 0.9% - Pelvic Organ Prolapse | Phase 4 | Withdrawn | The University of Texas Medical Branch, Galveston | 2024-07-01 | 2025-01-31 | |
| Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO) Nefopam, NaCl 0.9% - Total Hip Arthroplasty | Phase 3 | Not yet recruiting | University Hospital, Tours | 546 | 2024-04-01 | 2024-04-05 |
| Remimazolam for Emergence Delirium Prevention in Patients Undergoing Rhinoseptoplasty, FESS or Septoplasty Remimazolam 20 MG Injection [Byfavo], NaCl 0.9% - Remimazolam, Emergence Delirium | Phase 2 | Unknown | University Hospital of Split | 80 | 2024-03-06 | 2024-05-03 |
| Efficacy, Safety and Tolerability Study of Meloxicam Injection in Subjects After Abdominal Surgery Meloxicam Injection 30mg, Meloxicam Injection 60mg, Nacl 0.9% - Pain, Post-operative | Phase 2 | Unknown | Beijing Tide Pharmaceutical Co., Ltd | 108 | 2023-07-01 | 2023-07-18 |
| Effect of Hot Saline Irrigation on the Operative Field During Endoscopic Sinus Surgery Normal saline heated up to 50 °C - Rhinosinusitis | Not applicable | Completed | Rawalpindi Medical College | 60 | 2023-06-16 | 2024-04-02 |
| Effectiveness of Continous Adjuvant Lidocaine on General Anaesthesia on Tumor Craniotomy Surgery NaCl 0.9%, Adjuvant lidocaine continous - Surgery, Anesthesia; Functional | Not applicable | Completed | Universitas Indonesia | 60 | 2023-01-16 | 2024-02-16 |
| SAINT: Safe Induction of Labor Trial Buscopan 20 MG/ML Injectable Solution, Sodium bicarbonate, Placebo - Labor Complication, Induced; Birth | Phase 3 | Recruiting | Oslo University Hospital | 3000 | 2023-01-03 | 2024-04-04 |
| The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE) Dexmedetomidine, Placebo - Inhalation Anesthesia, Dexmedetomidine | Not applicable | Terminated | Ciusss de L'Est de l'Île de Montréal | 48 | 2022-12-05 | 2026-10-23 |
| 5-HT3 Receptor Antagonist and Respiratory Drive in Patients With ARDS Placebo, Ondansetron - Acute Respiratory Distress Syndrome | Phase 4 | Unknown | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 10 | 2022-11-10 | 2023-09-28 |
| The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of Fallot Dexmedetomidine Hcl 100 Mcg/mL Inj, Placebo - Congenital Heart Disease in Children, Cardiopulmonary Bypass | Phase 2 / Phase 3 | Completed | National Cardiovascular Center Harapan Kita Hospital Indonesia | 66 | 2022-10-10 | 2023-08-24 |
| Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study. Antioxidant therapy, NaCl 0.9% - Acute Myocardial Infarction, Ischemia-reperfusion Injury | Phase 1 | Completed | University of Chile | 18 | 2022-08-09 | 2024-01-12 |
| Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery Ropivacaine Hydrochloride Injection, Sodium chloride - Spondylolisthesis, Lumbar Disc Herniation | Phase 4 | Completed | Ilse van de Wijgert | 76 | 2022-06-01 | 2024-04-17 |
| Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock Tocilizumab, Dobutamine, NaCl 0.9% - Acute Myocardial Infarction, Cardiogenic Shock | Phase 2 | Active not recruiting | Copenhagen University Hospital, Rigshospitalet | 100 | 2022-03-13 | 2025-07-17 |
| CORTERAS STUDY: The Effect of Corticosteroids on Early Recovery After Major Surgery in Elderly Patients Methylprednisolone, NaCl 0.9% - Inflammatory Response, Weakness, Muscle | Phase 4 | Completed | Ziekenhuis Oost-Limburg | 751 | 2022-02-16 | 2026-01-27 |
| Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain. Morphine, Nacl 0.9% - Pain, Postoperative, Anesthesia | Not applicable | Active not recruiting | Tel-Aviv Sourasky Medical Center | 115 | 2022-02-16 | 2024-11-20 |
| The Effects of Intra-articular Platelet-Rich Plasma Injection on The Severity of Knee Osteoarthritis PRP, Normal Saline - Osteoarthritis, Knee | Not applicable | Completed | Universitas Bali Internasional | 106 | 2022-01-01 | 2023-02-10 |
| Study of Postoperative ICC Analgesia Ropivacain, NaCl 0.9% - Postoperative Analgesia | Phase 3 | Completed | University Hospital, Basel, Switzerland | 32 | 2021-12-15 | 2023-10-24 |
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Pain, Postoperative (7) · Pain (5) · Agnosia (4) · Inflammation (4) · Postoperative Nausea and Vomiting (4) · Sepsis (4) · COVID-19 (3) · Dengue (3) · Premature Birth (3) · Severe Dengue (3) · Anemia, Iron-Deficiency (2) · Blood Loss, Surgical (2) · Cerebral Palsy (2) · Cicatrix (2) · Coronary Artery Disease (2)
Assistance Publique - Hôpitaux de Paris (3) · National Cardiovascular Center Harapan Kita Hospital Indonesia (3) · Sanofi Pasteur, a Sanofi Company (3) · University Hospital, Basel, Switzerland (3) · University Hospital, Grenoble (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Balgrist University Hospital (2) · Guerbet (2) · Insel Gruppe AG, University Hospital Bern (2) · Nantes University Hospital (2) · Oslo University Hospital (2) · University of Liege (2) · Ahmad Jabir Rahyussalim (1) · Ascension Health (1) · Atox Bio Ltd (1)
France (14) · Switzerland (13) · Belgium (10) · Germany (9) · United States (8) · Indonesia (6) · Netherlands (6) · Israel (5) · Canada (3) · China (3) · Denmark (3) · Finland (3) · Italy (3) · Norway (3) · Austria (2)
Patrick Zingg, MD (2) · A. H. Epema, dr, MD (1) · Abraham IJ Gajardo, MD, PhD (1) · Alexander Wilmer, MD, PhD (1) · Aljaz Hojski, Dr. med. (1) · Amichai Rottenstreich (1) · Amie Jones, MD (1) · Aml M Aljaml (1) · Anders Opdahl, MD, PhD (1) · Ann Tran, MD (1) · Antonio Abbate, M.D., Ph.D. (1)
PMID 25157725, PMID 25534356, PMID 27187300, PMID 29515037, PMID 12519925, PMID 14578723, PMID 17063747, PMID 17197840, PMID 18648227, PMID 18676556, PMID 19287090, PMID 19301059, PMID 19424209, PMID 20421357, PMID 21153402, PMID 21186139, PMID 21508983, PMID 22187279, PMID 22383042, PMID 22693226, PMID 22776958, PMID 22894958, PMID 22939099, PMID 23400744, PMID 23427891, PMID 23453459, PMID 23635914, PMID 23839107, PMID 23842591, PMID 23937996, PMID 23966238, PMID 24015953, PMID 24189367, PMID 24232462, PMID 24467979, PMID 24634631, PMID 24862623, PMID 24969309, PMID 25121719, PMID 25158709, PMID 25169040, PMID 25482680, PMID 25541942, PMID 25563879, PMID 25863661, PMID 26066773, PMID 26914224, PMID 27130143, PMID 27244862, PMID 27282374
2004 (2), 2009 (2), 2014 (2), 2017 (2), 2016 (1), 2018 (1), 2019 (1), 2023 (1), R01DK101984 (1)