15 completed, 6 terminated, 6 unknown, 4 active not recruiting. 38 Phase 2, 4 Phase 1, 4 Phase 3.
Follow Metformin Hydrochloride: new trials by email Literature Review of Metformin Hydrochloride trials Research Report on Metformin Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Metformin to Improve Cardiac Function After LVAD Implantation Metformin Hydrochloride, Placebo - Heart Failure, Left Ventricular Assist Device | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 108 | 2026-07-01 | 2026-09-02 |
| Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia Metformin Hydrochloride, Placebo - Oral Leukoplakia | Phase 2 | Recruiting | Cairo University | 34 | 2026-02-01 | 2026-02-06 |
| Evaluating the Efficacy and Safety of Metformin in Vitiligo Metformin Hydrochloride - Vitiligo | Phase 2 | Withdrawn | University of Massachusetts, Worcester | 2025-07-01 | 2024-09-24 | |
| Glycemic Regulation as Endometriosis Adjunct Treatment Metformin Hydrochloride, Placebo - Pelvic Pain, Endometriosis | Phase 2 | Active not recruiting | Boston Children's Hospital | 14 | 2025-05-22 | 2026-07-16 |
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Clinical Trials Evaluating the Effect of Metformin Treatment on Function Endometrium in Women Diagnosed With Idiopathic Infertility Metformin Hydrochloride, Placebo - Infertility, Female | Phase 2 | Not yet recruiting | Medical University of Bialystok | 200 | 2023-08-30 | 2023-08-25 |
| Zimberelimab Plus Metformin for Recurrent Ovarian Clear Cell Carcinoma Zimberelimab, Metformin Hydrochloride - Ovarian Clear Cell Carcinoma | Phase 1 / Phase 2 | Unknown | Fudan University | 20 | 2023-03-01 | 2023-03-08 |
| Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function Metformin Hydrochloride - Cystic Fibrosis-related Diabetes, Cystic Fibrosis | Phase 2 | Recruiting | University of Kansas Medical Center | 30 | 2022-02-14 | 2026-04-15 |
| Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection Metformin Hydrochloride, Calcium and Vitamin D - Endoplasmic Reticulum Stress, Viral Infection | Phase 2 | Completed | Singapore General Hospital | 32 | 2021-10-22 | 2024-04-17 |
| Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse Metformin Hydrochloride - Osteosarcoma, Ewing Sarcoma | Phase 2 | Recruiting | Istituto Ortopedico Rizzoli | 67 | 2021-03-01 | 2023-08-04 |
| Oral Metformin for Treatment of ABCA4 Retinopathy Metformin hydrochloride - ABCA4 Retinopathy, Stargardt Disease | Phase 1 / Phase 2 | Active not recruiting | National Eye Institute (NEI) | 55 | 2020-11-23 | 2026-10-22 |
| Metformin Effect on Brain Function in Insulin Resistant Elderly People Metformin Hydrochloride, Placebo Oral Tablet - Insulin Resistance, Obesity | Phase 2 | Completed | Mayo Clinic | 40 | 2019-03-15 | 2024-06-18 |
| Sintilimab Combined With Metformin in First-Line Chemotherapy Refractory Advanced NSCLC Patients Sintilimab, Metformin Hydrochloride - Non Small Cell Lung Cancer | Phase 2 | Unknown | Tianjin Medical University Cancer Institute and Hospital | 43 | 2019-03-08 | 2019-03-19 |
| Metformin in Heart Failure Without Diabetes Metformin hydrochloride, Placebo - Heart Failure | Phase 2 | Terminated | Columbia University | 6 | 2019-02-15 | 2024-07-18 |
| Metformin Plus/Minus Fasting Mimicking Diet to Target the Metabolic Vulnerabilities of LKB1-inactive Lung Adenocarcinoma Metformin Hydrochloride, Cisplatin, Carboplatin - Advanced LKB1-inactive Lung Adenocarcinoma | Phase 2 | Unknown | Marina Garassino | 64 | 2018-10-30 | 2020-11-16 |
| Metformin Treatment for Colon Cancer Metformin Hydrochloride, Placebo oral capsule - Colon Cancer | Phase 2 | Completed | Zealand University Hospital | 48 | 2018-07-10 | 2022-03-03 |
| Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes Mellitus Propolis, Metformin, Placebo - Diabetes Mellitus, Type 2 | Phase 2 | Completed | University of Guadalajara | 36 | 2018-01-30 | 2022-11-07 |
| Nivolumab and Metformin Hydrochloride in Treating Patients With Stage III-IV Non-small Cell Lung Cancer That Cannot Be Removed by Surgery Laboratory Biomarker Analysis, Metformin Hydrochloride, Nivolumab - Recurrent Non-Small Cell Lung Carcinoma, Stage III Non-Small Cell Lung Cancer | Phase 2 | Unknown | Northwestern University | 17 | 2017-07-12 | 2020-10-14 |
| Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma Metformin Hydrochloride, Doxycycline, Metformin +Doxycycline - Larynx, LIP | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 7 | 2017-04-03 | 2026-01-29 |
| Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers Metformin Hydrochloride, Radioactive Iodine, Placebo - Thyroid | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 13 | 2017-01-05 | 2025-12-11 |
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Carcinoma, Non-Small-Cell Lung (4) · Diabetes Mellitus, Type 2 (4) · Prostatic Neoplasms (4) · Breast Neoplasms (2) · Heart Failure (2) · Leukoplakia, Oral (2) · Obesity (2) · Adenocarcinoma of Lung (1) · Adenocarcinoma, Bronchiolo-Alveolar (1) · Adenomatous Polyps (1) · Barrett Esophagus (1) · Brenner Tumor (1) · Camurati-Engelmann Syndrome (1) · Carcinoma, Ovarian Epithelial (1) · Chronic Pain (1)
National Cancer Institute (NCI) (4) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (3) · Columbia University (2) · Laboratorios Silanes S.A. de C.V. (2) · Boston Children's Hospital (1) · Cairo University (1) · Case Comprehensive Cancer Center (1) · Daiichi Sankyo (1) · Fudan University (1) · Gynecologic Oncology Group (1) · Istituto Ortopedico Rizzoli (1) · Kyongtae Ty Bae, M.D., Ph.D. (1) · Marina Garassino (1) · Mayo Clinic (1) · Medical Research Council (1)
United States (22) · Canada (5) · Mexico (3) · China (2) · Italy (2) · Denmark (1) · Egypt (1) · Israel (1) · Pakistan (1) · Puerto Rico (1) · Singapore (1) · Switzerland (1) · United Kingdom (1)
Jennifer Johnson, MD, PhD (2) · Alessandra Longhi, MD (1) · Amitabh Chak (1) · Barry Fine, MD (1) · Biren Saraiya, MD (1) · Brian P Brooks, M.D. (1) · David Bajor, MD (1) · Dawn L Hershman, MD (1) · Dingzhi Huang, M.D. (1) · Emilie P Colov, MD (1) · Jason Zell (1) · Jenny GH Low, MRCP (UK) (1) · Jessica Shim, MD (1)
PMID 32994091, PMID 11602624, PMID 14985505, PMID 15261145, PMID 18948947, PMID 18990168, PMID 19629071, PMID 20157582, PMID 21376230, PMID 22323820, PMID 22452894, PMID 22747660, PMID 23224736, PMID 23352126, PMID 24605899, PMID 25056707, PMID 25218668, PMID 26438237, PMID 26718929, PMID 26719232, PMID 27282289, PMID 27305912, PMID 27411588, PMID 27872127, PMID 28202779, PMID 28300506, PMID 28390753, PMID 28578639, PMID 28692586, PMID 29529169, PMID 29966520, PMID 30172698, PMID 30355464, PMID 31472446, PMID 31560068, PMID 33008091, PMID 33270906, PMID 33599706, PMID 33768205, PMID 34007848, PMID 34255745, PMID 34323922, PMID 34323924, PMID 34757812, PMID 34953525, PMID 35410255, PMID 35671327, PMID 36059000, PMID 36552855, PMID 37142371
P30CA023074 (2), U10CA180868 (2), 2004 (1), N01CN00031 (1), N01CN35158 (1), N01CN35160 (1), P30CA060553 (1), P30CA062203 (1), P30CA072720 (1), R01HL157942 (1), R21AG060139 (1), U10CA027469 (1), U10CA180830 (1)