22 completed, 3 active not recruiting, 3 recruiting, 3 terminated. 35 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 35 | Completed 22, Active not recruiting 3, Recruiting 3, Terminated 3, Withdrawn 3, Unknown 1 |
| Phase 2 | 4 | Active not recruiting 1, Completed 1, Recruiting 1, Unknown 1 |
Follow Metformin Hydrochloride: new trials by email Literature Review of Metformin Hydrochloride trials Research Report on Metformin Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Metformin to Improve Cardiac Function After LVAD Implantation Metformin Hydrochloride, Placebo - Heart Failure, Left Ventricular Assist Device | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 108 | 2026-07-01 | 2026-09-02 |
| Phase I Drug-Drug Interaction Study of UBT251 Injection in Participants With Overweight or Obesity UBT251, Metformin hydrochloride, Warfarin Sodium - Drug Drug Interaction (DDI), Pharmacokinetics and Pharmacodynamics | Phase 1 | Recruiting | The United Bio-Technology (Hengqin) Co., Ltd. | 48 | 2026-05-27 | 2026-08-25 |
| A Study in Healthy People to Test Whether BI 764198 Influences the Amount of Metformin in the Body Metformin hydrochloride, BI 764198 - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 14 | 2026-02-06 | 2026-07-06 |
| A Study of BGM0504 in Overweight or Obese Participants Paracetamol, Metformin Hydrochloride, Warfarin - Overweight or Obese | Phase 1 | Completed | BrightGene Bio-Medical Technology Co., Ltd. | 28 | 2025-03-25 | 2026-10-13 |
| Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib Saruparib, Digoxin, Furosemide - Advanced Solid Malignancies | Phase 1 | Active not recruiting | AstraZeneca | 41 | 2025-03-25 | 2026-10-01 |
| A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors TPX-0005, Metformin Hydrochloride, Digoxin - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 | Withdrawn | Turning Point Therapeutics, Inc. | 2024-11-15 | 2025-04-01 | |
| A Study in Healthy Men to Test Whether BI 1815368 Influences the Amount of Metformin in the Body Metformin hydrochloride, BI 1815368 - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 14 | 2024-11-08 | 2025-03-05 |
| Prevention of Progression of Prediabetes, Obesity and CV Risk Placebo, Rybelsus Tablet, Jardiance 25Mg Tablet - Pre-Diabetes, Weight, Body | Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 64 | 2024-09-11 | 2025-11-12 |
| A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood Zongertinib, Dabigatran-etexilate, Rosuvastatin - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 32 | 2024-08-20 | 2026-01-09 |
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Metformin Treatment in Infants After Perinatal Brain Injury Metformin Hydrochloride - Hypoxic Ischemic Encephalopathy of Newborn, Premature Birth | Phase 1 | Terminated | The Hospital for Sick Children | 1 | 2023-05-02 | 2024-03-07 |
| A Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Digoxin, Rosuvastatin, Metformin, and Furosemide in Healthy Male Subjects Savolitinib, Digoxin, Metformin Hydrochloride - Healthy Male Subjects | Phase 1 | Completed | AstraZeneca | 6 | 2023-04-25 | 2023-07-13 |
| Zimberelimab Plus Metformin for Recurrent Ovarian Clear Cell Carcinoma Zimberelimab, Metformin Hydrochloride - Ovarian Clear Cell Carcinoma | Phase 1 / Phase 2 | Unknown | Fudan University | 20 | 2023-03-01 | 2023-03-08 |
| Insulin Sensitizers Role in Control of PCOS Vicious Cycle. Metformin Hydrochloride, MI/DCI combination in 40:1 ratio, Combination of Metformin hydrochloride and MI/DCI - PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | Phase 1 | Completed | Zagazig University | 210 | 2022-08-01 | 2023-12-20 |
| GXR RM China BE Study (Darmstadt - Jiangsu) Test Glucophage® XR, Reference Glucophage® XR - Healthy | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 84 | 2022-07-25 | 2023-04-14 |
| Drug-durg Interaction of SHR3680 With Digoxin, Rosuvastatin Calcium and Metformin Hydrochloride SHR3680, digoxin, Rosuvastatin calcium - Drug-drug Interaction,SHR3680 | Phase 1 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 36 | 2021-01-08 | 2026-06-05 |
| GXR RM (Glucophage® Extended Release Reduced Mass) 500 Milligram (mg) Korea Bioequivalence (BE) Study Glucophage® XR RM Test, Glucophage® XR Reference - Healthy | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 81 | 2020-12-22 | 2023-12-29 |
| Oral Metformin for Treatment of ABCA4 Retinopathy Metformin hydrochloride - ABCA4 Retinopathy, Stargardt Disease | Phase 1 / Phase 2 | Active not recruiting | National Eye Institute (NEI) | 55 | 2020-11-23 | 2026-10-22 |
| A Study in Healthy People to Test Whether BI 730357 Affects How 4 Other Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Taken up in the Body BI 730357, CRESTOR®, Lenoxin® - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 15 | 2020-10-20 | 2023-09-06 |
| Metformin, Nelfinavir, and Bortezomib in Treating Patients With Relapsed and/or Refractory Multiple Myeloma Bortezomib, Metformin Hydrochloride, Nelfinavir Mesylate - Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma | Phase 1 | Completed | Mayo Clinic | 9 | 2019-04-17 | 2024-08-22 |
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Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Multiple Myeloma (2) · Obesity (2) · Overweight (2) · Anemia (1) · Blast Crisis (1) · Body Weight (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Camurati-Engelmann Syndrome (1) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Renal Cell (1) · Cardiovascular Diseases (1)
Boehringer Ingelheim (6) · AstraZeneca (2) · City of Hope Medical Center (2) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (2) · Merck KGaA, Darmstadt, Germany (2) · Merck Sharp & Dohme LLC (2) · BrightGene Bio-Medical Technology Co., Ltd. (1) · Case Comprehensive Cancer Center (1) · Fox Chase Cancer Center (1) · Fudan University (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · London Health Sciences Centre (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · National Eye Institute (NEI) (1)
United States (10) · Germany (8) · China (5) · Canada (2) · Australia (1) · Brazil (1) · Bulgaria (1) · Egypt (1) · France (1) · Indonesia (1) · Italy (1) · Moldova (1) · Pakistan (1) · Romania (1) · South Korea (1)
Angela Jain (1) · Brian P Brooks, M.D. (1) · Brian T Kalish, MD (1) · Carolina Solis-Herrera, MD (1) · Jennifer Eads, MD (1) · Jessica Altman, MD (1) · Libing Xiang (1) · Marc Dall'Era, MD (1) · Mary Mackenzie, MD (1)
PMID 28390753, PMID 31472446, PMID 33008091, PMID 34007848, PMID 35410255, PMID 36552855
2014 (1), 2016 (1), 2025 (1), P30CA006927 (1), P30CA043703 (1), P30CA093373 (1)