62 completed, 18 unknown, 10 recruiting, 10 terminated. 38 Phase 2, 35 Phase 1, 25 Phase 3, 16 Phase 4, 7 Early Phase 1.
Follow Metformin Hydrochloride: new trials by email Literature Review of Metformin Hydrochloride trials Research Report on Metformin Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Metformin to Improve Cardiac Function After LVAD Implantation Metformin Hydrochloride, Placebo - Heart Failure, Left Ventricular Assist Device | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 108 | 2026-07-01 | 2026-09-02 |
| Phase I Drug-Drug Interaction Study of UBT251 Injection in Participants With Overweight or Obesity UBT251, Metformin hydrochloride, Warfarin Sodium - Drug Drug Interaction (DDI), Pharmacokinetics and Pharmacodynamics | Phase 1 | Recruiting | The United Bio-Technology (Hengqin) Co., Ltd. | 48 | 2026-05-27 | 2026-08-25 |
| A Study in Healthy People to Test Whether BI 764198 Influences the Amount of Metformin in the Body Metformin hydrochloride, BI 764198 - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 14 | 2026-02-06 | 2026-07-06 |
| Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia Metformin Hydrochloride, Placebo - Oral Leukoplakia | Phase 2 | Recruiting | Cairo University | 34 | 2026-02-01 | 2026-02-06 |
| Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients Metformin Hydrochloride - Depression | Phase 4 | Recruiting | Fazaia Ruth Pfau Medical College | 140 | 2025-10-01 | 2025-09-19 |
| Evaluating the Efficacy and Safety of Metformin in Vitiligo Metformin Hydrochloride - Vitiligo | Phase 2 | Withdrawn | University of Massachusetts, Worcester | 2025-07-01 | 2024-09-24 | |
| Glycemic Regulation as Endometriosis Adjunct Treatment Metformin Hydrochloride, Placebo - Pelvic Pain, Endometriosis | Phase 2 | Active not recruiting | Boston Children's Hospital | 14 | 2025-05-22 | 2026-07-16 |
| Metformin vs Inositol vs Diet vs Combination Therapy in PCOS Metformin Hydrochloride, Myo-Inositol, Dietary Restriction - Polycystic Ovary Syndrome, Insulin Resistance | Not applicable | Completed | Islamabad Medical and Dental College | 192 | 2025-05-21 | 2026-02-02 |
| A Study of BGM0504 in Overweight or Obese Participants Paracetamol, Metformin Hydrochloride, Warfarin - Overweight or Obese | Phase 1 | Completed | BrightGene Bio-Medical Technology Co., Ltd. | 28 | 2025-03-25 | 2026-10-13 |
| Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib Saruparib, Digoxin, Furosemide - Advanced Solid Malignancies | Phase 1 | Active not recruiting | AstraZeneca | 41 | 2025-03-25 | 2026-10-01 |
| Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis Metformin - Psychosis, Cannabis Use | Phase 4 | Recruiting | Nova Scotia Health Authority | 24 | 2025-03-18 | 2026-04-07 |
| Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity Metformin Hydrochloride, Placebo - Exercise Capacity, Metformin | Phase 4 | Completed | University of Virginia | 14 | 2025-01-31 | 2026-06-17 |
| A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors TPX-0005, Metformin Hydrochloride, Digoxin - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 | Withdrawn | Turning Point Therapeutics, Inc. | 2024-11-15 | 2025-04-01 | |
| A Study in Healthy Men to Test Whether BI 1815368 Influences the Amount of Metformin in the Body Metformin hydrochloride, BI 1815368 - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 14 | 2024-11-08 | 2025-03-05 |
| Prevention of Progression of Prediabetes, Obesity and CV Risk Placebo, Rybelsus Tablet, Jardiance 25Mg Tablet - Pre-Diabetes, Weight, Body | Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 64 | 2024-09-11 | 2025-11-12 |
| Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes Metformin Hydrochloride, placebo - Gestational Diabetes | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 30 | 2024-09-11 | 2026-10-28 |
| A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood Zongertinib, Dabigatran-etexilate, Rosuvastatin - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 32 | 2024-08-20 | 2026-01-09 |
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Preeclampsia Intervention Netherlands Metformin Hydrochloride, Placebo - Pre-Eclampsia Onset Less Than 37 Weeks, Pre-Eclampsia | Phase 3 | Not yet recruiting | Amsterdam UMC | 180 | 2024-08-01 | 2024-06-11 |
| Efficacy of Canagliflozin Versus Metformin in Women With Polycystic Ovary Syndrome Canagliflozin 100mg Tab, Metformin Hydrochloride - Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease | Phase 4 | Unknown | Ping Li,MD | 50 | 2024-03-31 | 2024-02-13 |
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Diabetes Mellitus, Type 2 (23) · Obesity (9) · Breast Neoplasms (7) · Diabetes Mellitus (7) · Insulin Resistance (7) · Prostatic Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (5) · Polycystic Ovary Syndrome (5) · Heart Failure (4) · Pancreatic Neoplasms (3) · Prediabetic State (3) · Carcinoma, Ovarian Epithelial (2) · Diabetes, Gestational (2) · Fallopian Tube Neoplasms (2) · Hyperglycemia (2)
Boehringer Ingelheim (6) · Laboratorios Silanes S.A. de C.V. (5) · AstraZeneca (4) · National Cancer Institute (NCI) (4) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (4) · Case Comprehensive Cancer Center (3) · Merck KGaA, Darmstadt, Germany (3) · Cairo University (2) · City of Hope Medical Center (2) · Columbia University (2) · Mayo Clinic (2) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (2) · Merck Sharp & Dohme LLC (2) · Northwestern University (2) · Takeda (2)
United States (43) · Canada (11) · China (11) · Germany (9) · Mexico (8) · Italy (4) · Pakistan (4) · United Kingdom (4) · Egypt (3) · Bangladesh (2) · Denmark (2) · France (2) · India (2) · South Korea (2) · Spain (2)
Jennifer Johnson, MD, PhD (2) · AK Azad Chowdhury, PhD (1) · Adam Luginbuhl, MD (1) · Ahmed M Kamel, MSc. (1) · Akbay Sarybaev (1) · Alessandra Longhi, MD (1) · Amitabh Chak (1) · Angela Jain (1) · Anna Maria Storniolo, MD (1) · Anna Stanhewicz, PhD (1) · Anthony Joshua, MD (1) · Assimina Galli-Tsinopoulou, Professor (1) · Barbara Obermayer-Pietsch, Prof. MD (1)
PMID 32994091, PMID 35120288, PMID 38837240, PMID 11602624, PMID 14985505, PMID 15261145, PMID 17017829, PMID 18948947, PMID 18955637, PMID 18990168, PMID 19629071, PMID 20157582, PMID 20194822, PMID 20660041, PMID 21376230, PMID 21672123, PMID 21816980, PMID 22323820, PMID 22452894, PMID 22747660, PMID 23147210, PMID 23224736, PMID 23352126, PMID 23529567, PMID 23529570, PMID 24533710, PMID 24605899, PMID 24862430, PMID 25056707, PMID 25218668, PMID 26402520, PMID 26438237, PMID 26718929, PMID 26719232, PMID 27282289, PMID 27305912, PMID 27411588, PMID 27872127, PMID 28202779, PMID 28300506, PMID 28390753, PMID 28578639, PMID 28692586, PMID 29529169, PMID 29966520, PMID 30172698, PMID 30355464, PMID 30959948, PMID 31472446, PMID 31560068
2015 (2), P30CA023074 (2), P30CA043703 (2), U10CA180868 (2), 2004 (1), 2014 (1), 2016 (1), 2023 (1), 2025 (1), N01CN00031 (1), N01CN35158 (1), N01CN35160 (1), P30CA006927 (1), P30CA060553 (1), P30CA062203 (1)