12 completed, 8 unknown, 2 active not recruiting, 1 not yet recruiting. 25 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 12, Unknown 8, Active not recruiting 2, Not yet recruiting 1, Recruiting 1, Suspended 1 |
| Phase 2 | 4 | Unknown 2, Active not recruiting 1, Completed 1 |
Follow Metformin Hydrochloride: new trials by email Literature Review of Metformin Hydrochloride trials Research Report on Metformin Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preeclampsia Intervention Netherlands Metformin Hydrochloride, Placebo - Pre-Eclampsia Onset Less Than 37 Weeks, Pre-Eclampsia | Phase 3 | Not yet recruiting | Amsterdam UMC | 180 | 2024-08-01 | 2024-06-11 |
| Study to Evaluate the Efficacy and Safety of PB-201 in Type 2 Diabetic Mellitus Patients With Poor Glycemic Control Via Metformin Hydrochloride Monotherapy PB-201, PB-201 matched placebo, Metformin hydrochloride - Type 2 Diabetes Mellitus | Phase 3 | Unknown | PegBio Co., Ltd. | 546 | 2022-05-30 | 2022-04-22 |
| Efficacy and Safety of Metformin Glycinate Compared to Metformin Hydrochloride on the Progression of Type 2 Diabetes Metformin glycinate, Metformin Hydrochloride - Type 2 Diabetes | Phase 3 | Suspended | Laboratorios Silanes S.A. de C.V. | 500 | 2021-08-01 | 2021-06-29 |
| Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations Metformin Hydrochloride, Placebo - Non Small Cell Lung Cancer | Phase 3 | Recruiting | Instituto Nacional de Cancerologia de Mexico | 312 | 2021-07-15 | 2026-04-09 |
| Chiglitazar Added to Metformin for Type 2 Diabetes Chiglitazar 32mg, Chiglitazar 48mg, Placebo - Type 2 Diabetes | Phase 3 | Completed | Chipscreen Biosciences, Ltd. | 533 | 2021-07-06 | 2024-07-15 |
| Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors Lifestyle therapy, Metformin Hydrochloride, Placebo - Frailty, Sarcopenic Obesity | Phase 3 | Completed | VA Office of Research and Development | 114 | 2021-05-14 | 2026-09-14 |
| Study to Assess the Efficacy and Safety of Liraglutide in the Treatment of Type 2 Diabetes Victoza®., Metformin Hydrochloride, TQZ2451 - Type 2 Diabetes | Phase 3 | Unknown | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 424 | 2020-04-29 | 2020-07-08 |
| A Study of DBPR108 and Metformin Hydrochloride Combination Therapy in Patients With T2DM DBPR108, metformin hydrochloride, placepo - Type 2 Diabetes Mellitus | Phase 3 | Completed | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 214 | 2020-01-14 | 2021-06-28 |
| Metformin as RenoProtector of Progressive Kidney Disease Metformin Hydrochloride, Placebo Oral Tablet - Chronic Kidney Diseases | Phase 3 | Unknown | Universiteit Antwerpen | 290 | 2019-11-05 | 2023-12-19 |
| Comparing Efficacy and Safety of CinnaGen-liraglutide Versus Victoza® in Patients With Type II Diabetes Liraglutide 6 MG/ML Pen Injector, Metformin, Sulfonylurea/non-sulfonylurea insulin secretagogues - Diabetes Mellitus, Type 2 | Phase 3 | Unknown | Cinnagen | 300 | 2019-06-20 | 2019-02-06 |
| A Comparative Study of the Effect of Ayurvedic Drugs and Metformin in the Management of Diabetes Mellitus (Type II) Chhinnavahni Kashaya Vati along with Agnimantha Kwatha, Metformin Hydrochloride - Diabetes Mellitus, Type 2 | Phase 3 | Completed | A & U Tibbia College Karol Bagh | 48 | 2018-09-03 | 2022-07-11 |
| RCT Metformin for Reduction of Gestational Diabetes Mellitus Effects Metformin Hydrochloride, Placebo - Gestational Diabetes | Phase 3 | Completed | National University of Ireland, Galway, Ireland | 535 | 2017-06-06 | 2025-03-17 |
| Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer metformin hydrochloride, placebo - Breast Atypical Ductal Hyperplasia, Breast Ductal Carcinoma In Situ | Phase 3 | Active not recruiting | Alliance for Clinical Trials in Oncology | 86 | 2015-11-23 | 2026-10-08 |
| Efficacy Study of Metformin Glycinate on Postprandial Lipemia Metformin glycinate, Metformin Hydrochloride - Type 2 Diabetes | Phase 2 / Phase 3 | Unknown | Laboratorios Silanes S.A. de C.V. | 72 | 2015-10-01 | 2018-01-30 |
| Treating Insulin Resistance as a Strategy to Improve Outcome in Refractory Bipolar Disorder Placebo, Metformin - Bipolar Disorder | Phase 3 | Completed | Cynthia Calkin | 50 | 2015-09-01 | 2021-01-13 |
| Metformin Glycinate on Metabolic Control and Inflammatory Mediators in Type 2 Diabetes Metformin glycinate, Metformin hydrochloride - Type 2 Diabetes | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 203 | 2014-06-01 | 2018-01-30 |
| Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer Carboplatin, Laboratory Biomarker Analysis, Metformin Hydrochloride - Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 / Phase 3 | Unknown | Gynecologic Oncology Group | 469 | 2014-03-17 | 2021-09-30 |
| Comparative Study to Evaluate Efficacy and Safety When Metformin Hydrochloride 500 mg Once Daily is Added on to SYR-322 25 mg in Type 2 Diabetic Patients With Inadequate Glycemic Control Despite Treatment With SYR-322 25 mg in Addition to Diet and Exercise Therapy Alogliptin, Metformin hydrochloride, Metformin hydrochloride Placebo - Type 2 Diabetes Mellitus | Phase 3 | Completed | Takeda | 374 | 2014-02-01 | 2023-09-28 |
| The Metformin Active Surveillance Trial (MAST) Study Metformin, Placebo - Prostate Cancer | Phase 3 | Unknown | University Health Network, Toronto | 408 | 2013-10-01 | 2024-01-24 |
| A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer metformin hydrochloride, placebo - Breast Cancer | Phase 3 | Completed | Canadian Cancer Trials Group | 3649 | 2010-08-13 | 2023-09-13 |
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Diabetes Mellitus, Type 2 (13) · Diabetes Mellitus (3) · Prostatic Neoplasms (2) · Bipolar Disorder (1) · Breast Carcinoma In Situ (1) · Breast Neoplasms (1) · Breast Neoplasms, Male (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Carcinoma, Non-Small-Cell Lung (1) · Diabetes, Gestational (1) · Frailty (1) · HELLP Syndrome (1) · Insulin Resistance (1) · Neoplasms (1) · Obesity (1)
Laboratorios Silanes S.A. de C.V. (5) · AstraZeneca (2) · A & U Tibbia College Karol Bagh (1) · Alliance for Clinical Trials in Oncology (1) · Amsterdam UMC (1) · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (1) · Canadian Cancer Trials Group (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Chipscreen Biosciences, Ltd. (1) · Cinnagen (1) · Cynthia Calkin (1) · Gynecologic Oncology Group (1) · Instituto Nacional de Cancerologia de Mexico (1) · Medical Research Council (1) · National University of Ireland, Galway, Ireland (1)
Mexico (7) · United States (5) · China (4) · Canada (3) · United Kingdom (3) · Switzerland (2) · Argentina (1) · Belgium (1) · Czechia (1) · France (1) · Germany (1) · Hungary (1) · India (1) · Ireland (1) · Italy (1)
Anthony Joshua, MD (1) · Cynthia Calkin, MD FRCPC (1) · Dennis T Villareal, MD (1) · Dr. Richa Bhardwaj, M.D. (Ayu.) (1) · Francisco G Padilla Padilla, M.D (1) · Jorge V Yamamoto Cuevas, M.D (1)
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