12 completed, 5 unknown, 2 active not recruiting, 2 terminated. 7 Phase 2, 6 Phase 3, 4 Not applicable, 3 Phase 4, 2 Early Phase 1.
Follow Memantine Hydrochloride: new trials by email Literature Review of Memantine Hydrochloride trials Research Report on Memantine Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Memantine Hydrochloride in Prostate Cancer Patients Memantine Hydrochloride - Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostate Cancer | Phase 2 | Not yet recruiting | Bin Xu | 15 | 2025-11-01 | 2025-11-19 |
| The Study of Atezolizumab, Bevacizumab and Memantine in Patients With Hepatocellular Carcinoma (HCC) Memantine Hydrochloride, Bevacizumab, Atezolizumab - Hepatocellular Carcinoma | Phase 2 | Recruiting | Inova Health Care Services | 19 | 2025-02-25 | 2026-10-16 |
| Ultrasound-Guided Stellate Ganglion Block for Alzheimer's Disease Ultrasound-Guided Stellate Ganglion Block, Memantine hydrochloride, Donepezil hydrochloride - Alzheimer's Disease(AD), Cognitive Dysfunction | Not applicable | Completed | Taizhou Second People's Hospital | 40 | 2025-01-26 | 2026-01-21 |
| Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury Memantine Hydrochloride - Treatment of Cognitive Deficits After Traumatic Brain Injury | Phase 3 | Completed | Assiut University | 60 | 2024-01-01 | 2024-08-07 |
| Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery (TASD) Memantine Hydrochloride, Placebo - Chronic Subdural Hematoma | Early Phase 1 | Withdrawn | University of New Mexico | 2022-06-01 | 2026-02-27 | |
| A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor Biospecimen Collection, Cognitive Assessment, Magnetic Resonance Imaging - Central Nervous System Carcinoma | Phase 3 | Active not recruiting | Children's Oncology Group | 162 | 2022-05-10 | 2026-07-13 |
| Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury Memantine Hydrochloride - Traumatic Brain Injury | Not applicable | Unknown | Minia University | 70 | 2021-11-26 | 2022-09-08 |
| Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability Biospecimen Collection, Magnetic Resonance Imaging, Memantine Hydrochloride - Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | NRG Oncology | 152 | 2021-06-08 | 2026-09-14 |
| Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases Conformal Whole Brain Radiotherapy with Unilateral Hippocampal Avoidance, Conformal Whole Brain Radiotherapy with Bilateral Hippocampal Avoidance, Memantine Hydrochloride - Metastatic Malignant Neoplasm to Brain | Phase 2 | Unknown | National Taiwan University Hospital | 72 | 2021-04-01 | 2021-03-17 |
| Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors Cogstate Assessment Battery, Memantine, Memantine Hydrochloride - Malignant Central Nervous System Neoplasm, Primary Central Nervous System Neoplasm | Early Phase 1 | Completed | Mayo Clinic | 18 | 2020-02-17 | 2024-11-21 |
| Memantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions Memantine Hydrochloride, Placebo - Autism, Autism Spectrum Disorder | Phase 3 | Terminated | Massachusetts General Hospital | 25 | 2018-11-13 | 2026-02-25 |
| Effect of Memantine on Cognitive Impairment in Patients With Epilepsy Memantine Hydrochloride, Placebo - Epilepsy | Phase 1 | Completed | Assiut University | 100 | 2018-10-01 | 2020-06-04 |
| A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCD Memantine Hydrochloride - Sickle Cell Disease | Phase 2 | Unknown | HaEmek Medical Center, Israel | 40 | 2018-02-02 | 2019-11-01 |
| Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors Memantine, Placebo, Cognitive Assessment - Glioma of Brain, Craniopharyngioma | Phase 2 | Completed | St. Jude Children's Research Hospital | 41 | 2017-11-07 | 2026-06-23 |
| Memantine Treatment in Alzheimer's Disease Patients Memantine Hydrochloride - Alzheimer Disease | Phase 4 | Unknown | Wei Cuibai | 222 | 2017-07-15 | 2017-05-30 |
| Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases Whole brain radiation therapy with hippocampal avoidance, Memantine, Whole brain radiation therapy - Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Completed | NRG Oncology | 518 | 2015-07-01 | 2026-09-10 |
| Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking memantine hydrochloride, placebo - Breast Cancer, Colorectal Cancer | Phase 2 | Completed | Wake Forest University Health Sciences | 130 | 2012-08-01 | 2021-09-28 |
| Memantine for Executive Dysfunction in Adults With ADHD: A Pilot Study Placebo, Memantine Hydrochloride, OROS-Methylphenidate - Attention Deficit Hyperactivity Disorder (ADHD), Executive Function Deficits (EFD) | Not applicable | Completed | Massachusetts General Hospital | 33 | 2012-05-01 | 2014-04-08 |
| Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy Mefloquine, Memantine Hydrochloride, Metformin Hydrochloride - Glioblastoma, Gliosarcoma | Phase 1 | Terminated | M.D. Anderson Cancer Center | 144 | 2011-09-14 | 2025-05-07 |
| Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease Memantine - Alzheimer's Disease | Phase 4 | Completed | Shanghai Mental Health Center | 26 | 2008-07-01 | 2010-12-03 |
Showing 20 of 24. Sign in to see all of them.
Brain Neoplasms (4) · Alzheimer Disease (3) · Attention Deficit Disorder with Hyperactivity (2) · Brain Injuries, Traumatic (2) · Cognitive Dysfunction (2) · Frontotemporal Dementia (2) · Lung Neoplasms (2) · Prostatic Neoplasms (2) · Anemia, Sickle Cell (1) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1)
Massachusetts General Hospital (3) · Assiut University (2) · NRG Oncology (2) · Bin Xu (1) · Children's Oncology Group (1) · HaEmek Medical Center, Israel (1) · Inova Health Care Services (1) · King's College London (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Minia University (1) · National Taiwan University Hospital (1) · Shanghai Mental Health Center (1) · St. Jude Children's Research Hospital (1) · Taizhou Second People's Hospital (1)
United States (13) · Canada (3) · Egypt (3) · China (2) · Israel (1) · Puerto Rico (1) · Taiwan (1) · United Kingdom (1)
Ariel Koren, Professor (1) · Arthur Winer, MD (1) · Clive G Ballard, Professor (1) · Ed Juszczak, PhD (1) · Feng-Ming Hsu, MD, PhD (1) · Gagan Joshi, MD (1) · Heather M. Conklin, PhD (1) · Ibrahim Talaat, MD (1) · Jill Mollis, PhD (1) · John Spangler, MD (1) · Jon E Grant, MD, JD, MPH (1) · Joseph Biederman, MD (1) · Marc N. Potenza, M.D, Ph.D. (1) · Maria Luisa Margallo-Lana, PhD (1) · Nadia N Laack (1)
PMID 20721537, PMID 21792308, PMID 22674572, PMID 32058845, PMID 36006807, PMID 37811711, PMID 40340434
UG1CA189867 (2), R21CA218625 (1), U01CA246568 (1), U10CA081851 (1), U24CA196173 (1), UG1CA189955 (1)