22 completed, 14 unknown, 3 terminated, 2 not yet recruiting. 14 Not applicable, 12 Phase 4, 10 Phase 2, 6 Phase 1, 6 Phase 3.
Follow Lidocaine IV: new trials by email Literature Review of Lidocaine IV trials Research Report on Lidocaine IV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia rachi morphine anesthesia, laparotomy, Lidocaine IV - Digestive System Disease, Surgery | Phase 3 | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 76 | 2026-09-01 | 2026-08-25 |
| Intravenous Lidocaine to Prevent Post-Fundal Pressure Headache During Cesarean Section Lidocaine IV, Saline 0.9% - Intravenous Lidocaine, Fundal Pressure | Phase 3 | Recruiting | Tanta University | 680 | 2026-07-01 | 2026-07-06 |
| Lidocaine Decreases Postoperative Lung Cancer Reoccurance and Metatasis Risk Lidocaine (drug) - Non-Small Cell Lung Cancer, Recurrence | Not applicable | Not yet recruiting | First Affiliated Hospital of Ningbo University | 1400 | 2026-01-01 | 2026-01-16 |
| Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy Dexmedetomidine Injection [Precedex], Lidocaine IV - Analgesia | Phase 4 | Completed | Assiut University | 64 | 2024-04-01 | 2026-05-14 |
| Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study. Lidocaine IV - Perioperative Pain Management | Phase 1 / Phase 2 | Unknown | Cairo University | 69 | 2024-03-15 | 2024-05-28 |
| Postoperative Pain Control Following Hysteroscopy Lidocaine IV, Saline - Postoperative Pain, Postoperative Nausea | Not applicable | Completed | Afyonkarahisar Health Sciences University | 150 | 2024-03-01 | 2025-07-23 |
| Intravenous Lidocaine for Treating Intrathecal Fentanyl Induced Pruritus Lidocaine IV - Pruritus Caused by Drug | Early Phase 1 | Unknown | Ain Shams University | 54 | 2024-03-01 | 2024-02-06 |
| Magnesium Sulphate and Lidocaine in Hemodynamic Changes and Cortisol Levels Magnesium Sulfate 20 MG/ML, Lidocaine IV, saline solution - Intubation Complication | Phase 1 | Completed | Arsil Radiansyah | 30 | 2024-01-31 | 2024-07-24 |
| Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis Lidocaine Iv, Placebo - Sickle Cell Disease, Sickle Cell Crisis | Phase 2 | Unknown | Community Medical Center, Toms River, NJ | 100 | 2024-01-01 | 2023-08-29 |
| Effect of Intraoperative Intravenous Lidocaine on Postoperative Pain and Return of Bowel Function After Cesarean Sections Lidocaine IV, Placebo - Postoperative Pain, Postoperative Return of Bowel Function | Phase 2 | Completed | Cairo University | 60 | 2023-12-01 | 2024-05-30 |
| Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery Esmolol Injection, Lidocaine IV - Chronic Rhinosinusitis, Enhanced Recovery After Surgery | Phase 1 / Phase 2 | Unknown | The Second People's Hospital of Huai'an | 60 | 2023-11-21 | 2024-06-13 |
| Modulating Surgery-Induced Blood-Brain Barrier Disruption in Elderly Dexmedetomidine Injection [Precedex], Lidocaine IV, normal saline - Delirium, Postoperative | Not applicable | Unknown | Samsung Medical Center | 108 | 2023-10-25 | 2024-04-17 |
| Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery Lidocaine IV, Ketamine Injectable Solution - Colorectal (Colon or Rectal) Cancer, Inflammation | Not applicable | Recruiting | University Tunis El Manar | 50 | 2023-10-01 | 2025-11-18 |
| The Efficacy Of Lidocaine Infusion IN Chronic Unilateral Migraine Headache Lidocaine IV - Chronic Migraine, Headache | Phase 2 | Unknown | Alexandria University | 80 | 2023-10-01 | 2023-10-31 |
| Dexmedetomidine or Lidocaine for Lessening the Hemodynamic Responses to Laryngoscopy and Intubation Dexmedetomidine nebulization, Lidocaine nebulization, Dexmedetomidine IV - Anesthesia Intubation Complication | Not applicable | Completed | Zagazig University | 100 | 2023-07-12 | 2024-02-28 |
| Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery Lidocaine IV, Dexmedetomidine IV, intrathecal morphine - Colorectal Cancer, Anesthesia | Not applicable | Completed | Samsung Medical Center | 114 | 2023-04-12 | 2025-04-02 |
| Lidocaine Versus Fentanyl for Hemodynamic Stability Lidocaine IV, Fentanyl - Hypertension, Fentanyl | Phase 4 | Completed | Theodor Bilharz Research Institute | 40 | 2023-04-01 | 2024-08-23 |
| Dose Systemic Lidocaine Improve the Quality of Recovery After Colorectal Endoscopic Submucosal Dissection lidocaine, 0.9% saline, Propofol - Postoperative Recovery | Phase 4 | Completed | Fujian Provincial Hospital | 234 | 2023-02-24 | 2024-05-10 |
| Comparison of the Effect of Lidocaine Infusion Applied at Different Doses During Lumbar Spinal Surgery on Hemodynamics and Postoperative Pain Lidocaine IV, Lidocaine - Post Operative Pain, Hemodynamic Instability | Not applicable | Unknown | Ankara University | 80 | 2023-02-10 | 2024-01-30 |
| Bolus vs. Continuous IV Lidocaine Against Post-Extubation Cough in Post-Thyroidectomy Patients Lidocaine IV - Cough | Phase 2 | Completed | Universitas Padjadjaran | 40 | 2023-02-02 | 2023-09-22 |
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Pain, Postoperative (10) · Agnosia (4) · Pain (3) · Acute Pain (2) · Carcinoma, Non-Small-Cell Lung (2) · Colonic Neoplasms (2) · Cough (2) · Emergence Delirium (2) · Headache (2) · Inflammation (2) · Pancreatic Neoplasms (2) · Abdominal Pain (1) · Anemia, Sickle Cell (1) · Colorectal Neoplasms (1) · Digestive System Diseases (1)
Ain Shams University (2) · Alexandria University (2) · Cairo University (2) · Kasr El Aini Hospital (2) · Rhode Island Hospital (2) · Samsung Medical Center (2) · Zagazig University (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Afyonkarahisar Health Sciences University (1) · Aga Khan University Hospital, Pakistan (1) · Ajou University School of Medicine (1) · Ankara University (1) · Arsil Radiansyah (1) · Assiut University (1) · Community Medical Center, Toms River, NJ (1)
Egypt (15) · United States (9) · China (4) · South Korea (3) · Indonesia (2) · Turkey (Türkiye) (2) · Australia (1) · Brazil (1) · France (1) · Greece (1) · Lebanon (1) · Netherlands (1) · New Zealand (1) · Pakistan (1) · Poland (1)
Ali Zahalka, MD, PhD (1) · Alshaimaa Kamel, M.D (1) · Ardi Zulfariansyah, MD (1) · Ash Tewari (1) · Ayman Abougabal, MD (1) · Bernhard Riedel, MB.ChB (1) · Betul Ahat (1) · Bruno LC Araujo, MSc, EDAIC (1) · Changshun Huang, MD (1) · Edward Suh, MD (1) · Elliott Chinn, DO (1) · Guillem Pla, MD (1) · Haris Sheikh, MBBS (1) · Ignatia K Hallis, MD (1)
PMID 10772585, PMID 11554951, PMID 12873949, PMID 15957691, PMID 16389388, PMID 16632328, PMID 17042843, PMID 19250287, PMID 19478674, PMID 19919581, PMID 22083262, PMID 22494645, PMID 22679539, PMID 22846676, PMID 23121612, PMID 23703410, PMID 24009246, PMID 24216403, PMID 24879167, PMID 25205974, PMID 25469757, PMID 26427363, PMID 28017170, PMID 28683817, PMID 28737263, PMID 29283170, PMID 29570151, PMID 29595671, PMID 29718287, PMID 29864216, PMID 30047158, PMID 30229370, PMID 30674285, PMID 31054568, PMID 31870279, PMID 31920239, PMID 32174664, PMID 33109859, PMID 33141959, PMID 34061894, PMID 34145431, PMID 34408981, PMID 34704710, PMID 34873540, PMID 34956071, PMID 35167059, PMID 35295486, PMID 35609890, PMID 35667730, PMID 38022613
2025 (1), R35GM146822 (1)