9 completed, 8 unknown, 4 terminated, 1 not yet recruiting. 22 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 22 | Completed 9, Unknown 8, Terminated 4, Not yet recruiting 1 |
| Phase 2 | 6 | Unknown 4, Completed 1, Not yet recruiting 1 |
Follow Levosimendan: new trials by email Literature Review of Levosimendan trials Research Report on Levosimendan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Levosimendan in Acute Decompensated Heart Failure Levosimendan, Standard care - Acute Decompensated Heart Failure (ADHF) | Phase 2 / Phase 3 | Not yet recruiting | Chittagong Medical College | 332 | 2025-12-01 | 2025-12-04 |
| Using TEE to Evaluate the Effect of Levosimendan on Patients With ARDS Associated With RVD During MV levosimendan, 5% glucose injection - Transesophageal Echocardiography, Acute Respiratory Distress Syndrome | Phase 2 / Phase 3 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 58 | 2023-03-22 | 2023-03-14 |
| Levosimendan Versus Placebo Before Tricuspid Valve Surgery in Patients With Right Ventricular Dysfunction Levosimendan, PLACEBO - Patients Referred for an Isolated or a Combined Surgical Correction of Functional Moderate to Severe Tricuspid | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 230 | 2023-01-23 | 2023-05-15 |
| LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients Levosimendan, Placebo of Levosimendan - Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 206 | 2021-08-27 | 2025-03-21 |
| Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients Levosimendan, Placebo - Cardiovascular Risk Factor | Phase 3 | Completed | Medical University of Vienna | 230 | 2020-10-10 | 2025-05-08 |
| Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS) Levosimendan, Placebos - Cardiac Output, Low | Phase 2 / Phase 3 | Unknown | María de los Ángeles Tena Pajuelo | 300 | 2020-06-17 | 2020-07-24 |
| Interest of Levosimendan in Reducing Weaning Failures of ExtraCorporeal Life Support - ECLS Levosimendan, Cernevit - Acute Decompensated Heart Failure | Phase 3 | Terminated | Centre Hospitalier Universitaire Dijon | 82 | 2020-02-24 | 2026-09-28 |
| A Clinical Study on Levosimendan Improvement of Prognosis of ARDS Patients by Optimizing Pulmonary Hemodynamics Levosimendan - ARDS, Human | Phase 3 | Unknown | Shenzhen Second People's Hospital | 120 | 2019-07-01 | 2019-07-15 |
| Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension Levosimendan - Amyotrophic Lateral Sclerosis | Phase 3 | Terminated | Orion Corporation, Orion Pharma | 227 | 2019-06-26 | 2023-03-09 |
| Clinical Trial in Patients Who Have Suffered a Heart Attack and Who Have Undergone Catheterization Treated With Levosimendan Levosimendan, Placebos - ST Elevation Myocardial Infarction | Phase 3 | Unknown | Hospital Universitario de Canarias | 184 | 2018-11-17 | 2021-02-11 |
| Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS Levosimendan, Placebo for levosimendan - Amyotrophic Lateral Sclerosis | Phase 3 | Completed | Orion Corporation, Orion Pharma | 496 | 2018-06-21 | 2022-05-11 |
| Levosimendan in Acute Kidney Injury Study Levosimendan, Conventional therapy - Acute Kidney Injury | Phase 2 / Phase 3 | Completed | VieCuri Medical Centre | 68 | 2016-09-01 | 2026-08-21 |
| Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass Levosimendan, Placebo - Coronary Artery Bypass Grafting, Mitral Valve Surgery | Phase 3 | Completed | Tenax Therapeutics, Inc. | 882 | 2014-07-01 | 2018-06-21 |
| Levosimendan Versus Dobutamine for Renal Function in Heart Failure Levosimendan, Dobutamine - Cardiorenal Syndrome | Phase 3 | Completed | Göteborg University | 33 | 2014-04-01 | 2020-02-25 |
| Preoperative Levosimendan in CABG Patients With Poor LV Function levosimendan, Placebo - Coronary Artery Bypass Grafting, Left Ventricular Dysfonction | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 335 | 2013-06-01 | 2016-02-25 |
| Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients Levosimendan, Placebo - Muscle Weakness Conditions, Weaning Failure | Phase 2 / Phase 3 | Unknown | University Medical Center Nijmegen | 42 | 2012-09-01 | 2015-06-10 |
| ELEVATE Early LEvosimendan Vs Usual Care in Advanced Chronic hearT failurE Diuretics, Levosimendan - Advanced Chronic Heart Failure | Phase 3 | Terminated | Niguarda Hospital | 13 | 2011-02-01 | 2017-04-10 |
| Efficacy and Safety of Pulsed Infusions of Levosimendan in Outpatients With Advanced Heart Failure Levosimendan, Placebo - Chronic Stable Heart Failure | Phase 3 | Unknown | Medical University Innsbruck | 120 | 2009-08-01 | 2010-08-30 |
| Study of Blood Concentrations and Physiologic Effects of Levosimendan Given During Heart Surgery Levosimendan - Heart Failure | Phase 3 | Terminated | Emory University | 1 | 2005-05-01 | 2013-11-15 |
| Levosimendan Versus Dobutamine in Shock Patients Levosimendan, Dobutamine - Cardiogenic Shock, Septic Shock | Phase 2 / Phase 3 | Unknown | Wentworth Area Health Services | 40 | 2004-10-01 | 2005-06-24 |
Showing 20 of 22. Sign in to see all of them.
Heart Failure (5) · Cardiac Output, Low (3) · Amyotrophic Lateral Sclerosis (2) · Respiratory Distress Syndrome (2) · Shock, Cardiogenic (2) · Acute Kidney Injury (1) · Cardio-Renal Syndrome (1) · Cardiovascular Diseases (1) · Renal Insufficiency (1) · ST Elevation Myocardial Infarction (1) · Sepsis (1) · Shock (1) · Shock, Septic (1) · Ventricular Dysfunction, Left (1) · Ventricular Dysfunction, Right (1)
Assistance Publique - Hôpitaux de Paris (3) · Abbott (2) · Orion Corporation, Orion Pharma (2) · Centre Hospitalier Universitaire Dijon (1) · Chittagong Medical College (1) · Emory University (1) · Göteborg University (1) · Hospital Universitario de Canarias (1) · María de los Ángeles Tena Pajuelo (1) · Medical University Innsbruck (1) · Medical University of Vienna (1) · Niguarda Hospital (1) · Shenzhen Second People's Hospital (1) · Tenax Therapeutics, Inc. (1) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1)
France (6) · United States (6) · Australia (4) · Austria (4) · Canada (4) · Netherlands (4) · Spain (4) · Italy (3) · Sweden (3) · Belgium (2) · China (2) · Finland (2) · Germany (2) · Ireland (2) · United Kingdom (2)
Bernard Cholley, MD, PhD (1) · Elisabet B Berastegui Garcia, Cardiac surgery (1) · Fabrizio Oliva, MD (1) · Gemma S Sanchez Espin, Cardiac Surgery (1) · Jerrold H Levy, MD (1) · Johann Altenberger, MD (1) · John Alexander, MD (1) · Jos Le Noble, MD PhD (1) · Juan B Bustamante Munguira, Cardiac surgery (1) · Kristjan Karason, MD, PhD (1) · Leo Heunks, MD, PhD (1)
PMID 34536404, PMID 10889132, PMID 15769768, PMID 16461840, PMID 17473298, PMID 19539144, PMID 19700350, PMID 23620700, PMID 24126568, PMID 24621834, PMID 24920349, PMID 25734940, PMID 25989324, PMID 26468714, PMID 27496105, PMID 27705084, PMID 27914501, PMID 28316276, PMID 28785469, PMID 28787507, PMID 29718383, PMID 30369310, PMID 35063963, PMID 35263653, PMID 40593481, PMID 41324946, PMID 42101006
2019 (2), 2008 (1)