6 completed, 3 withdrawn, 2 terminated, 1 unknown. 12 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 6, Withdrawn 3, Terminated 2, Unknown 1 |
| Phase 2 | 3 | Completed 2, Withdrawn 1 |
Follow IVIG: new trials by email Literature Review of IVIG trials Research Report on IVIG
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Harnessing Allo-immunity to Enhance Immune Checkpoint Inhibitor Responses in Advanced NSCLC Poly ICLC, IVIG - Stage IV NSCLC | Phase 1 / Phase 2 | Withdrawn | VA Office of Research and Development | 2024-06-04 | 2024-09-19 | |
| A Clinical Study of ANX005 and IVIG in Subjects With Guillain Barré Syndrome (GBS) ANX005, Intravenous immunoglobulin - Guillain-Barré Syndrome | Phase 1 | Completed | Annexon, Inc. | 14 | 2020-01-29 | 2021-08-11 |
| IVIG (Gamunex-C) Treatment Study for POTS Subjects IVIG, Albumin - Postural Tachycardia Syndrome | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 30 | 2018-10-29 | 2024-09-19 |
| Single Dose Study of ANX005 in Healthy Volunteers ANX005, IVIg, Placebos - Safety and Tolerability in Healthy Volunteers | Phase 1 | Terminated | Annexon, Inc. | 27 | 2016-12-01 | 2020-08-20 |
| Study in End-stage Renal Disease Patients Awaiting Kidney Transplant to Investigate the Potential Effect of IVIG Treatment on the Pharmacokinetics and Pharmacodynamics of LFG316 LFG316, IVIG - Kidney Transplantation | Phase 1 | Completed | Novartis Pharmaceuticals | 8 | 2016-08-26 | 2020-12-11 |
| IVIg to Treat BK Viremia in Kidney Transplant Recipients IVIg, Placebo - Kidney Transplantation, BK Virus | Phase 1 | Completed | Massachusetts General Hospital | 16 | 2016-05-01 | 2021-09-05 |
| Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Gamunex-C - Corneal Neovascularization, Corneal Graft Failure | Phase 1 | Withdrawn | University of Utah | 2014-07-01 | 2016-08-05 | |
| IVIG in Acute Ischemic Stroke: A Pilot Study Privigen, Normal Saline - Ischemic Stroke | Phase 1 | Withdrawn | Inova Health Care Services | 2013-03-01 | 2013-11-11 | |
| A Safety Study of Tocilizumab to Improve Transplant Rates in Highly Sensitized Patients Awaiting Kidney Transplantation Tocilizumab, Intravenous Immunoglobulin - End Stage Renal Disease (ESRD) | Phase 1 / Phase 2 | Completed | Cedars-Sinai Medical Center | 10 | 2012-06-01 | 2016-08-25 |
| IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral Load Intravenous immunoglobulin therapy - Heart Failure | Phase 1 | Unknown | Maastricht University Medical Center | 40 | 2009-02-01 | 2009-02-04 |
| The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis IgM-enriched Intravenous Immunoglobulins, Human Albumin - Polyneuropathies | Phase 1 | Terminated | Medical University of Vienna | 38 | 2004-12-01 | 2013-06-04 |
| Intravenous Immunoglobulin (IVIg) for the Treatment of Stiff-Man Syndrome (SMS) IVIg - Muscle Rigidity, Spasm | Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 20 | 1996-04-01 | 2006-07-14 |
Carcinoma, Non-Small-Cell Lung (1) · Corneal Neovascularization (1) · Critical Illness (1) · Guillain-Barre Syndrome (1) · Heart Failure (1) · Ischemic Stroke (1) · Kidney Failure, Chronic (1) · Multiple Organ Failure (1) · Muscle Rigidity (1) · Polyneuropathies (1) · Postural Orthostatic Tachycardia Syndrome (1) · Sepsis (1) · Spasm (1) · Stiff-Person Syndrome (1) · Stroke (1)
Annexon, Inc. (2) · Cedars-Sinai Medical Center (1) · Inova Health Care Services (1) · Maastricht University Medical Center (1) · Massachusetts General Hospital (1) · Medical University of Vienna (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Novartis Pharmaceuticals (1) · University of Texas Southwestern Medical Center (1) · University of Utah (1) · VA Office of Research and Development (1)
United States (8) · Australia (1) · Austria (1) · Bangladesh (1) · Denmark (1) · Netherlands (1)
Balamurali K Ambati, M.D., Ph.D., M.B.A. (1) · Beverly C Walters, MD (1) · Christian Madl, MD (1) · Farrah Kheradmand, MD (1) · Hannah Gilligan, MD (1) · Jack Cochran, MD (1) · Jason Lickliter, MBBS PhD (1) · Milan Basta, MD (1) · Sandy Calman, MD (1) · Stanley Jordan, MD (1) · Stephane Heymans, MD, PhD (1) · Steven Vernino, MD, PhD (1)
PMID 20386074, PMID 24088271, PMID 29202623, PMID 32301258, PMID 41071936