28 completed, 5 recruiting, 2 terminated, 2 unknown. 16 Phase 3, 11 Phase 2, 10 Phase 1, 6 Phase 4, 1 Not applicable.
Follow Intravenous placebo: new trials by email Literature Review of Intravenous placebo trials Research Report on Intravenous placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Versus Intravenous Tranexamic Acid in Off-Pump Coronary Artery Bypass Surgery Oral tranexamic acid, Exacyl®, Intravenous placebo - Coronary Artery Disease, Perioperative Bleeding | Phase 4 | Not yet recruiting | Clinique Saint-Luc | 160 | 2026-10-01 | 2026-07-31 |
| Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND) Intravenous rhPro-UK, Intravenous placebo, Endovascular thrombectomy - Acute Ischemic Stroke | Phase 3 | Recruiting | First Affiliated Hospital Xi'an Jiaotong University | 820 | 2026-04-07 | 2026-09-09 |
| Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain Intravenous oxytocin, Intravenous placebo, Intranasal oxytocin - Pain, Acute | Phase 2 | Completed | Wake Forest University Health Sciences | 24 | 2025-11-05 | 2026-06-30 |
| Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using Microneurography Intravenous Oxytocin, Intravenous Placebo - Acute Pain | Phase 2 | Recruiting | Wake Forest University Health Sciences | 60 | 2025-10-22 | 2026-02-13 |
| Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window Intravenous rhTNK-tPA, Intravenous placebo, Endovascular thrombectomy - Stroke, Acute Ischemic | Phase 3 | Recruiting | Xinqiao Hospital of Chongqing | 820 | 2025-10-21 | 2025-12-31 |
| Evaluation of the Safety and Tolerability of Gemini in Subjects With Stage 3-4 Chronic Kidney Disease. Intravenous Gemini, Intravenous placebo - Renal Insufficiency, Chronic, Chronic Kidney Disease stage3 | Phase 1 / Phase 2 | Completed | Revelation Biosciences, Inc | 40 | 2025-01-20 | 2025-10-29 |
| Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II) Intravenous Dexmedetomidine, Sublingual Dexmedetomidine, Intravenous Placebo - Delirium | Phase 3 | Recruiting | Massachusetts General Hospital | 1800 | 2025-01-06 | 2026-09-14 |
| SAINT: Safe Induction of Labor Trial Buscopan 20 MG/ML Injectable Solution, Sodium bicarbonate, Placebo - Labor Complication, Induced; Birth | Phase 3 | Recruiting | Oslo University Hospital | 3000 | 2023-01-03 | 2024-04-04 |
| A Preliminary Study to Evaluate PF-07264660 in Healthy Participants PF-07264660 intravenous single ascending dose, PF-07264660 subcutaneous multiple ascending dose, Intravenous placebo - Healthy | Phase 1 | Completed | Pfizer | 59 | 2022-08-16 | 2024-06-06 |
| ACTISAVE: ACuTe Ischemic Stroke Study Evaluating Glenzocimab Used as Add-on Therapy Versus placEbo Intravenous glenzocimab (ACT017) 1000 mg, Intravenous Placebo - Acute Ischemic Stroke | Phase 2 / Phase 3 | Completed | Acticor Biotech | 438 | 2021-09-23 | 2024-07-03 |
| First-in-human Trial With Single-dose C5a-neutralizing AON-D21 in Healthy Male Subjects Intravenous AON-D21, Intravenous placebo - Healthy | Phase 1 | Completed | Aptarion Biotech AG | 40 | 2021-08-03 | 2022-01-12 |
| Lidocaine And Neuromonitoring in Thyroid Surgery Intravenous lidocaine, Intravenous placebo, Intra-cuff lidocaine - Thyroid Neoplasm, Parathyroid Neoplasms | Phase 4 | Completed | Saint Petersburg State University, Russia | 110 | 2021-01-25 | 2024-03-21 |
| A Study to Test the Safety, Pharmacokinetics, and Efficacy of UCB9741 in Healthy Study Participants and in Study Participants With Atopic Dermatitis UCB9741, Intravenous Placebo, Subcutaneous Placebo - Atopic Dermatitis | Phase 1 / Phase 2 | Completed | UCB Biopharma SRL | 107 | 2020-11-27 | 2026-04-06 |
| Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation Rezafungin for Injection, Posaconazole, Fluconazole - Candidemia, Mycoses | Phase 3 | Completed | Mundipharma Research Limited | 602 | 2020-05-11 | 2026-04-13 |
| Acute Ischemic Stroke Interventional Study Intravenous ACT017 1000 mg, Intravenous Placebo - Acute Ischemic Stroke | Phase 1 / Phase 2 | Completed | Acticor Biotech | 160 | 2019-03-06 | 2021-10-06 |
| Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis Rezafungin for Injection, Caspofungin, Fluconazole - Candidemia, Mycoses | Phase 3 | Completed | Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 199 | 2018-10-07 | 2023-01-06 |
| Evaluation of Preoperative N1539 in Total Knee Arthroplasty N1539, Placebo - Pain, Postoperative | Phase 3 | Completed | Baudax Bio | 194 | 2018-02-19 | 2023-05-25 |
| Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI Methylphenidate Pill, Oral Placebo, Intravenous Placebo - Normal Physiology | Phase 1 | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 25 | 2018-01-29 | 2024-05-28 |
| Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients intravenous Placebo, Metoprolol Injectable Product, Romote Ischemic Conditioning (RIC) - Anterior Myocardial Infarction, Heart Failure | Not applicable | Completed | Harbin Medical University | 1206 | 2017-11-28 | 2021-11-04 |
| Evaluation of Preoperative N1539 in Colorectal Surgery N1539, Placebo - Pain, Postoperative | Phase 3 | Completed | Baudax Bio | 57 | 2017-10-24 | 2023-06-18 |
Showing 20 of 40. Sign in to see all of them.
Agnosia (9) · Pain, Postoperative (9) · Pain (6) · Ischemic Stroke (4) · Acute Pain (3) · Candidemia (3) · Candidiasis, Invasive (3) · Fungemia (3) · Mycoses (3) · Bunion (2) · Candidiasis (2) · Hemorrhage (2) · Invasive Fungal Infections (2) · Pathologic Processes (2) · Renal Insufficiency, Chronic (2)
Baudax Bio (6) · Acticor Biotech (2) · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (2) · Janssen Research & Development, LLC (2) · Wake Forest University Health Sciences (2) · Amgen (1) · Aptarion Biotech AG (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Centre Hospitalier Universitaire de Besancon (1) · Clinique Saint-Luc (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · GlaxoSmithKline (1) · Harbin Medical University (1) · INSYS Therapeutics Inc (1)
United States (22) · Germany (8) · France (7) · Belgium (6) · China (5) · Italy (5) · Spain (5) · United Kingdom (5) · Canada (4) · Russia (4) · Bulgaria (3) · Greece (3) · Hungary (3) · Netherlands (3) · Norway (3)
Andrea Comenducci, MD (2) · Benjamin Javillier, MD (1) · Brian M Ilfeld, M.D., M.S. (1) · Daojun Hong, MD (1) · Dardo G Tomasi, Ph.D. (1) · Giovanni DeCastro (1) · James C Eisenach, MD (1) · James Eisenach, MD (1) · Jan A Koenig, M.D. (1) · Kyle Christensen, DDS (1)
PMID 30737315, PMID 33438477, PMID 38008099, PMID 38502709, PMID 39468640, PMID 39529079, PMID 41940006, PMID 42044230, PMID 23706709, PMID 29093180, PMID 30590833, PMID 30777900, PMID 30786162, PMID 31883327, PMID 32021411, PMID 32453485, PMID 32955088, PMID 33094682, PMID 33128208, PMID 33502533, PMID 34519964, PMID 36442484, PMID 36765261, PMID 37773627, PMID 37938560, PMID 38109535, PMID 38267188, PMID 38326458, PMID 38885234, PMID 38985561, PMID 39259571, PMID 40032397, PMID 41194465
2014 (1), 2015 (1), 2016 (1), 2017 (1), 2018 (1), P01NS119159 (1)