26 completed, 3 unknown, 2 active not recruiting, 2 recruiting. 15 Phase 2, 9 Not applicable, 9 Phase 1, 3 Phase 3, 1 Early Phase 1.
Follow Intranasal Insulin: new trials by email Literature Review of Intranasal Insulin trials Research Report on Intranasal Insulin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Exercise and Intranasal Insulin in Type 2 Diabetes Intranasal Insulin, Intranasal Placebo, High Intensity Exercise - Type 2 Diabetes, Insulin Sensitivity/Resistance | Phase 2 / Phase 3 | Recruiting | Rutgers, The State University of New Jersey | 60 | 2026-08-03 | 2026-06-30 |
| Dopamine and Insulin in Psychosis Intranasal Insulin, Placebo, Low dose insulin infusion - First Episode Psychosis (FEP) | Not applicable | Not yet recruiting | Medical University of Vienna | 46 | 2026-01-01 | 2025-11-28 |
| Evaluation Study of New Compounds With Potential Use in Schizophrenia URB597, intranasal Insulin, Cannabidiol CR - Schizophrenia | Phase 1 | Withdrawn | Central Institute of Mental Health, Mannheim | 2025-01-31 | 2025-03-21 | |
| Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft. intranasal saline group, intranasal insulin, Intranasal dexmedetomidine - Post Operative Cognitive Dysfunction | Early Phase 1 | Completed | Minia University | 150 | 2024-12-27 | 2026-08-25 |
| Intranasal Insulin for Posttraumatic Stress Disorder Intranasal insulin, Placebo - PTSD | Phase 2 | Completed | VA Connecticut Healthcare System | 10 | 2024-10-31 | 2026-07-13 |
| Effects of Antipsychotics on Brain Insulin Action in Females Olanzapine 2.5Mg Oral Tablet, Placebo, Insulin Lispro 100 UNT/ML - Insulin Resistance, Menstrual Cycle | Not applicable | Active not recruiting | Centre for Addiction and Mental Health | 15 | 2024-06-03 | 2026-09-28 |
| COMMETS- Combination MCI Metabolic Syndrome Semaglutide, Intranasal insulin, Semaglutide placebo - Alzheimer Disease, Mild Cognitive Impairment | Phase 2 | Recruiting | Rutgers, The State University of New Jersey | 80 | 2024-01-30 | 2026-07-27 |
| Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional Magnetic Resonance Imaging (fMRI) Intranasal insulin - Healthy | Phase 1 | Completed | Florian Schmitzberger | 6 | 2023-11-17 | 2024-03-21 |
| Does Abnormal Insulin Action in the Brain Underlie Cognitive and Metabolic Dysfunction in Schizophrenia Intranasal insulin, Placebo - Schizophrenia, Healthy | Not applicable | Active not recruiting | Centre for Addiction and Mental Health | 20 | 2023-04-01 | 2026-09-25 |
| Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients Intranasal insulin, Intranasal saline - Postoperative Neurocognitive Disorders | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 438 | 2022-11-07 | 2022-11-14 |
| Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants Intranasal insulin - Out-Of-Hospital Cardiac Arrest, Healthy | Phase 1 | Completed | Robert Silbergleit | 24 | 2021-10-04 | 2026-03-27 |
| Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents Humalog, Saline nasal spray - Major Depressive Disorder, Depression | Not applicable | Completed | Centre for Addiction and Mental Health | 24 | 2021-09-01 | 2026-03-31 |
| Intranasal Insulin for COVID-19-related Smell Loss Insulin - Anosmia, Smell Loss | Phase 3 | Completed | Universidad Panamericana | 27 | 2021-01-04 | 2022-07-18 |
| Intranasal Insulin and Olanzapine Study in Healthy Volunteers OLANZapine 2.5 MG, Placebo, Insulin Lispro 100 UNT/ML - Healthy Controls | Phase 1 | Completed | Centre for Addiction and Mental Health | 46 | 2019-10-22 | 2026-10-19 |
| Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders Intranasal Insulin - Psychosis, Schizophrenia | Phase 2 | Completed | Mclean Hospital | 87 | 2019-10-01 | 2026-09-03 |
| "Effect of Central Insulin Administration on Whole-body Insulin Sensitivity in Women" intranasal insulin, Placebo spray - Insulin Sensitivity | Not applicable | Completed | University Hospital Tuebingen | 29 | 2019-04-21 | 2021-09-05 |
| Effect of Intranasal Insulin on Postoperative Cognitive Dysfunction Intranasal insulin - Middle Aged Patients | Unknown | Minia University | 57 | 2019-02-25 | 2019-11-06 | |
| PINIT Study: Primary Intranasal Insulin Trial intranasal insulin, Placebo - Diabetes Mellitus, Type 1 | Phase 2 | Completed | Technical University of Munich | 38 | 2018-05-25 | 2021-06-22 |
| Effect of Intranasal Insulin on Cognitive Processes and Appetite Intranasal Insulin, Intranasal Placebo - Obesity | Not applicable | Completed | University of Birmingham | 64 | 2018-04-23 | 2019-05-02 |
| Raclopride-PET/MRT intranasal insulin, Placebo - Diabetes Mellitus, Type 2 | Not applicable | Completed | University Hospital Tuebingen | 24 | 2017-02-20 | 2024-05-14 |
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Insulin Resistance (12) · Diabetes Mellitus, Type 2 (6) · Diabetes Mellitus (4) · Schizophrenia (4) · Alzheimer Disease (2) · Diabetes Mellitus, Type 1 (2) · Anosmia (1) · Bipolar Disorder (1) · COVID-19 (1) · Cognitive Dysfunction (1) · Dementia (1) · Depression (1) · Depressive Disorder, Major (1) · Hyperinsulinism (1) · Hypogonadism (1)
Centre for Addiction and Mental Health (4) · University Health Network, Toronto (3) · University Hospital Tuebingen (3) · Ajna Hamidovic (2) · Minia University (2) · Rutgers, The State University of New Jersey (2) · Beth Israel Deaconess Medical Center (1) · Bronx Veterans Medical Research Foundation, Inc (1) · Central Institute of Mental Health, Mannheim (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Florian Schmitzberger (1) · German Diabetes Center (1) · Jeff Burns, MD (1) · Mclean Hospital (1) · Medical University of Vienna (1)
United States (13) · Canada (7) · Germany (6) · Egypt (2) · Australia (1) · Austria (1) · China (1) · Israel (1) · Mexico (1) · New Zealand (1) · United Kingdom (1)
Ajna Hamidovic, PharmD (1) · Anette-G. Ziegler, Prof. Dr. (1) · Cheryl Bushnell, MD (1) · F. Markus Leweke, MD (1) · Florian Schmitzberger, MD (1) · Gihyun Yoon, MD (1) · Jeffrey M Burns, MD (1) · Julia Golier, MD (1) · Leonard C Harrison, MBBS MD DSc (1) · Maartje SPetter, PhD (1) · Mahavir Agarwal, MBBS, PhD, MD (1) · Mahavir Agarwal, MD, PhD (1) · Margaret K Hahn, PhD, MD (1) · Martin Heni, MD (1)
PMID 24101698, PMID 25249577, PMID 25576060, PMID 29557250, PMID 30515210, PMID 31022213, PMID 31689708, PMID 33862126, PMID 34091488, PMID 36441736, PMID 37735274, PMID 42658795
R01DK147509 (1)